Influenza vaccination in pregnancy: careful assessment confirms safety concerns for the offspring
Valid evidence does not support universal influenza vaccination for pregnant women, the LTE objections are unfounded. The observational evidence is less valid than that from RCTs: important safety signals in all the RCTs require high consideration. In RCTs, influenza vaccinated women have mostly loc...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-09-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2019.1605818 |
| _version_ | 1797677377795391488 |
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| author | Alberto Donzelli |
| author_facet | Alberto Donzelli |
| author_sort | Alberto Donzelli |
| collection | DOAJ |
| description | Valid evidence does not support universal influenza vaccination for pregnant women, the LTE objections are unfounded. The observational evidence is less valid than that from RCTs: important safety signals in all the RCTs require high consideration. In RCTs, influenza vaccinated women have mostly local adverse effects, while their offspring shows a nonsignificant excess of deaths, and a significant excess of serious presumed/neonatal infections in the larger RCT. Several Authors have financial relationships with vaccine producers, several conclusions omit the safety signals. A cited systematic review has methodological problems and excluded important published RCTs. Waiting for new independent RCTs, the precautionary principle suggests avoiding to promote pregnant women vaccination. Health services could offer it highlighting existing uncertainties, with balanced informations allowing informed choices. |
| first_indexed | 2024-03-11T22:44:12Z |
| format | Article |
| id | doaj.art-e2daec1bcd274a7e80dfa8529d98e46f |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:44:12Z |
| publishDate | 2019-09-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-e2daec1bcd274a7e80dfa8529d98e46f2023-09-22T08:45:31ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2019-09-011592168217010.1080/21645515.2019.16058181605818Influenza vaccination in pregnancy: careful assessment confirms safety concerns for the offspringAlberto Donzelli0Fondazione Allineare Sanità e SaluteValid evidence does not support universal influenza vaccination for pregnant women, the LTE objections are unfounded. The observational evidence is less valid than that from RCTs: important safety signals in all the RCTs require high consideration. In RCTs, influenza vaccinated women have mostly local adverse effects, while their offspring shows a nonsignificant excess of deaths, and a significant excess of serious presumed/neonatal infections in the larger RCT. Several Authors have financial relationships with vaccine producers, several conclusions omit the safety signals. A cited systematic review has methodological problems and excluded important published RCTs. Waiting for new independent RCTs, the precautionary principle suggests avoiding to promote pregnant women vaccination. Health services could offer it highlighting existing uncertainties, with balanced informations allowing informed choices.http://dx.doi.org/10.1080/21645515.2019.1605818influenza vaccinationpregnant womenhealthy vaccinee biascochrane systematic reviewserious adverse eventsoffspring deaths |
| spellingShingle | Alberto Donzelli Influenza vaccination in pregnancy: careful assessment confirms safety concerns for the offspring Human Vaccines & Immunotherapeutics influenza vaccination pregnant women healthy vaccinee bias cochrane systematic review serious adverse events offspring deaths |
| title | Influenza vaccination in pregnancy: careful assessment confirms safety concerns for the offspring |
| title_full | Influenza vaccination in pregnancy: careful assessment confirms safety concerns for the offspring |
| title_fullStr | Influenza vaccination in pregnancy: careful assessment confirms safety concerns for the offspring |
| title_full_unstemmed | Influenza vaccination in pregnancy: careful assessment confirms safety concerns for the offspring |
| title_short | Influenza vaccination in pregnancy: careful assessment confirms safety concerns for the offspring |
| title_sort | influenza vaccination in pregnancy careful assessment confirms safety concerns for the offspring |
| topic | influenza vaccination pregnant women healthy vaccinee bias cochrane systematic review serious adverse events offspring deaths |
| url | http://dx.doi.org/10.1080/21645515.2019.1605818 |
| work_keys_str_mv | AT albertodonzelli influenzavaccinationinpregnancycarefulassessmentconfirmssafetyconcernsfortheoffspring |