Molecular Epidemiology of Dengue in Panama: 25 Years of Circulation
Dengue virus (DENV) is the most prevalent arbovirus in terms of human public health importance globally. In addition to DENV epidemiological surveillance, genomic surveillance may help investigators understand the epidemiological dynamics, geographic distribution, and temporal patterns of DENV circu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-08-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/11/8/764 |
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| author | Yamilka Díaz María Chen-Germán Evelia Quiroz Jean-Paul Carrera Julio Cisneros Brechla Moreno Lizbeth Cerezo Alex O. Martinez-Torres Lourdes Moreno Itza Barahona de Mosca Blas Armién Rubing Chen Nikos Vasilakis Sandra López-Vergès |
| author_facet | Yamilka Díaz María Chen-Germán Evelia Quiroz Jean-Paul Carrera Julio Cisneros Brechla Moreno Lizbeth Cerezo Alex O. Martinez-Torres Lourdes Moreno Itza Barahona de Mosca Blas Armién Rubing Chen Nikos Vasilakis Sandra López-Vergès |
| author_sort | Yamilka Díaz |
| collection | DOAJ |
| description | Dengue virus (DENV) is the most prevalent arbovirus in terms of human public health importance globally. In addition to DENV epidemiological surveillance, genomic surveillance may help investigators understand the epidemiological dynamics, geographic distribution, and temporal patterns of DENV circulation. Herein, we aimed to reconstruct the molecular epidemiology and phylogeny of DENV in Panama to connect the epidemiological history of DENV dispersal and circulation in Latin America. We retrospectively analyzed the epidemiological data obtained during 25 years of DENV surveillance in Panama. DENV was reintroduced in Panama in 1993 after a 35 year absence of autochthonous transmission. The increase in the number of total dengue cases has been accompanied by an increase in severe and fatal cases, with the highest case fatality rate recorded in 2011. All four serotypes were detected in Panama, which is characterized by serotype replacement and/or co-circulation of multiple serotypes. Phylogenetic analysis of datasets collected from envelope (E) gene sequences obtained from viruses isolated from human sera demonstrated that circulating viruses were highly diverse and clustered in distinct clades, with co-circulation of clades from the same genotype. Our analyses also suggest that Panamanian strains were related to viruses from different regions of the Americas, suggesting a continuous exchange of viruses within the Americas. |
| first_indexed | 2024-12-10T21:18:42Z |
| format | Article |
| id | doaj.art-e2db0f517f9044a38b45dff9bd46c7e7 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-10T21:18:42Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-e2db0f517f9044a38b45dff9bd46c7e72022-12-22T01:33:12ZengMDPI AGViruses1999-49152019-08-0111876410.3390/v11080764v11080764Molecular Epidemiology of Dengue in Panama: 25 Years of CirculationYamilka Díaz0María Chen-Germán1Evelia Quiroz2Jean-Paul Carrera3Julio Cisneros4Brechla Moreno5Lizbeth Cerezo6Alex O. Martinez-Torres7Lourdes Moreno8Itza Barahona de Mosca9Blas Armién10Rubing Chen11Nikos Vasilakis12Sandra López-Vergès13Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Justo Arosemena avenue and 35st street, 0816-02593 Panama, Republic of PanamaDepartment of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Justo Arosemena avenue and 35st street, 0816-02593 Panama, Republic of PanamaFaculty of Medicine, University of Panama, 3366 Panama 4, Republic of PanamaDepartment of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Justo Arosemena avenue and 35st street, 0816-02593 Panama, Republic of PanamaDepartment of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Justo Arosemena avenue and 35st street, 0816-02593 Panama, Republic of PanamaDepartment of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Justo Arosemena avenue and 35st street, 0816-02593 Panama, Republic of PanamaNational Department of Epidemiology, Ministry of Health, 0816-06812 Panama 1, Republic of PanamaDepartment of Microbiology and Parasitology, University of Panama, 3366 Panama 4, Republic of PanamaNational Department of Epidemiology, Ministry of Health, 0816-06812 Panama 1, Republic of PanamaNational Department of Epidemiology, Ministry of Health, 0816-06812 Panama 1, Republic of PanamaDepartment of Research in Emergent and Zoonotic diseases, Gorgas Memorial Institute of Health Studies, Justo Arosemena avenue and 35st street, 0816-02593 Panama, Republic of PanamaDepartment of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555-0609, USADepartment of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555-0609, USADepartment of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Justo Arosemena avenue and 35st street, 0816-02593 Panama, Republic of PanamaDengue virus (DENV) is the most prevalent arbovirus in terms of human public health importance globally. In addition to DENV epidemiological surveillance, genomic surveillance may help investigators understand the epidemiological dynamics, geographic distribution, and temporal patterns of DENV circulation. Herein, we aimed to reconstruct the molecular epidemiology and phylogeny of DENV in Panama to connect the epidemiological history of DENV dispersal and circulation in Latin America. We retrospectively analyzed the epidemiological data obtained during 25 years of DENV surveillance in Panama. DENV was reintroduced in Panama in 1993 after a 35 year absence of autochthonous transmission. The increase in the number of total dengue cases has been accompanied by an increase in severe and fatal cases, with the highest case fatality rate recorded in 2011. All four serotypes were detected in Panama, which is characterized by serotype replacement and/or co-circulation of multiple serotypes. Phylogenetic analysis of datasets collected from envelope (E) gene sequences obtained from viruses isolated from human sera demonstrated that circulating viruses were highly diverse and clustered in distinct clades, with co-circulation of clades from the same genotype. Our analyses also suggest that Panamanian strains were related to viruses from different regions of the Americas, suggesting a continuous exchange of viruses within the Americas.https://www.mdpi.com/1999-4915/11/8/764Dengue virusmolecular epidemiologyFlavivirusthe AmericasPanamaoutbreakarbovirus |
| spellingShingle | Yamilka Díaz María Chen-Germán Evelia Quiroz Jean-Paul Carrera Julio Cisneros Brechla Moreno Lizbeth Cerezo Alex O. Martinez-Torres Lourdes Moreno Itza Barahona de Mosca Blas Armién Rubing Chen Nikos Vasilakis Sandra López-Vergès Molecular Epidemiology of Dengue in Panama: 25 Years of Circulation Viruses Dengue virus molecular epidemiology Flavivirus the Americas Panama outbreak arbovirus |
| title | Molecular Epidemiology of Dengue in Panama: 25 Years of Circulation |
| title_full | Molecular Epidemiology of Dengue in Panama: 25 Years of Circulation |
| title_fullStr | Molecular Epidemiology of Dengue in Panama: 25 Years of Circulation |
| title_full_unstemmed | Molecular Epidemiology of Dengue in Panama: 25 Years of Circulation |
| title_short | Molecular Epidemiology of Dengue in Panama: 25 Years of Circulation |
| title_sort | molecular epidemiology of dengue in panama 25 years of circulation |
| topic | Dengue virus molecular epidemiology Flavivirus the Americas Panama outbreak arbovirus |
| url | https://www.mdpi.com/1999-4915/11/8/764 |
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