Same agent, different messages: insight into transcriptional regulation by SIN3 isoforms
Abstract SIN3 is a global transcriptional coregulator that governs expression of a large repertoire of gene targets. It is an important player in gene regulation, which can repress or activate diverse gene targets in a context-dependent manner. SIN3 is required for several vital biological processes...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2018-04-01
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| Series: | Epigenetics & Chromatin |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13072-018-0188-y |
| _version_ | 1818216715196039168 |
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| author | Ashlesha Chaubal Lori A. Pile |
| author_facet | Ashlesha Chaubal Lori A. Pile |
| author_sort | Ashlesha Chaubal |
| collection | DOAJ |
| description | Abstract SIN3 is a global transcriptional coregulator that governs expression of a large repertoire of gene targets. It is an important player in gene regulation, which can repress or activate diverse gene targets in a context-dependent manner. SIN3 is required for several vital biological processes such as cell proliferation, energy metabolism, organ development, and cellular senescence. The functional flexibility of SIN3 arises from its ability to interact with a large variety of partners through protein interaction domains that are conserved across species, ranging from yeast to mammals. Several isoforms of SIN3 are present in these different species that can perform common and specialized functions through interactions with distinct enzymes and DNA-binding partners. Although SIN3 has been well studied due to its wide-ranging functions and highly conserved interaction domains, precise roles of individual SIN3 isoforms have received less attention. In this review, we discuss the differences in structure and function of distinct SIN3 isoforms and provide possible avenues to understand the complete picture of regulation by SIN3. |
| first_indexed | 2024-12-12T06:56:22Z |
| format | Article |
| id | doaj.art-e2dc44e82415431bb95ee91054647ec1 |
| institution | Directory Open Access Journal |
| issn | 1756-8935 |
| language | English |
| last_indexed | 2024-12-12T06:56:22Z |
| publishDate | 2018-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Epigenetics & Chromatin |
| spelling | doaj.art-e2dc44e82415431bb95ee91054647ec12022-12-22T00:33:57ZengBMCEpigenetics & Chromatin1756-89352018-04-0111111110.1186/s13072-018-0188-ySame agent, different messages: insight into transcriptional regulation by SIN3 isoformsAshlesha Chaubal0Lori A. Pile1Department of Biological Sciences, Wayne State UniversityDepartment of Biological Sciences, Wayne State UniversityAbstract SIN3 is a global transcriptional coregulator that governs expression of a large repertoire of gene targets. It is an important player in gene regulation, which can repress or activate diverse gene targets in a context-dependent manner. SIN3 is required for several vital biological processes such as cell proliferation, energy metabolism, organ development, and cellular senescence. The functional flexibility of SIN3 arises from its ability to interact with a large variety of partners through protein interaction domains that are conserved across species, ranging from yeast to mammals. Several isoforms of SIN3 are present in these different species that can perform common and specialized functions through interactions with distinct enzymes and DNA-binding partners. Although SIN3 has been well studied due to its wide-ranging functions and highly conserved interaction domains, precise roles of individual SIN3 isoforms have received less attention. In this review, we discuss the differences in structure and function of distinct SIN3 isoforms and provide possible avenues to understand the complete picture of regulation by SIN3.http://link.springer.com/article/10.1186/s13072-018-0188-ySIN3 isoformsTranscriptionChromatinPosttranslational modification |
| spellingShingle | Ashlesha Chaubal Lori A. Pile Same agent, different messages: insight into transcriptional regulation by SIN3 isoforms Epigenetics & Chromatin SIN3 isoforms Transcription Chromatin Posttranslational modification |
| title | Same agent, different messages: insight into transcriptional regulation by SIN3 isoforms |
| title_full | Same agent, different messages: insight into transcriptional regulation by SIN3 isoforms |
| title_fullStr | Same agent, different messages: insight into transcriptional regulation by SIN3 isoforms |
| title_full_unstemmed | Same agent, different messages: insight into transcriptional regulation by SIN3 isoforms |
| title_short | Same agent, different messages: insight into transcriptional regulation by SIN3 isoforms |
| title_sort | same agent different messages insight into transcriptional regulation by sin3 isoforms |
| topic | SIN3 isoforms Transcription Chromatin Posttranslational modification |
| url | http://link.springer.com/article/10.1186/s13072-018-0188-y |
| work_keys_str_mv | AT ashleshachaubal sameagentdifferentmessagesinsightintotranscriptionalregulationbysin3isoforms AT loriapile sameagentdifferentmessagesinsightintotranscriptionalregulationbysin3isoforms |