Plasmodium falciparum Plasmepsin 2 Duplications, West Africa
Dihydroartemisinin/piperaquine (DHA/PPQ) is increasingly deployed as an antimalaria drug in Africa. We report the detection in Mali of Plasmodium falciparum infections carrying plasmepsin 2 duplications (associated with piperaquine resistance) in 7/65 recurrent infections within 2 months after DHA/P...
| मुख्य लेखकों: | , , , , , , , , , , |
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| स्वरूप: | लेख |
| भाषा: | English |
| प्रकाशित: |
Centers for Disease Control and Prevention
2018-08-01
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| श्रृंखला: | Emerging Infectious Diseases |
| विषय: | |
| ऑनलाइन पहुंच: | https://wwwnc.cdc.gov/eid/article/24/8/18-0370_article |
| _version_ | 1828462010086457344 |
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| author | Juliana Inoue Miguel Silva Bakary Fofana Kassim Sanogo Andreas Mårtensson Issaka Sagara Anders Björkman Maria Isabel Veiga Pedro Eduardo Ferreira Abdoulaye Djimde José Pedro Gil |
| author_facet | Juliana Inoue Miguel Silva Bakary Fofana Kassim Sanogo Andreas Mårtensson Issaka Sagara Anders Björkman Maria Isabel Veiga Pedro Eduardo Ferreira Abdoulaye Djimde José Pedro Gil |
| author_sort | Juliana Inoue |
| collection | DOAJ |
| description | Dihydroartemisinin/piperaquine (DHA/PPQ) is increasingly deployed as an antimalaria drug in Africa. We report the detection in Mali of Plasmodium falciparum infections carrying plasmepsin 2 duplications (associated with piperaquine resistance) in 7/65 recurrent infections within 2 months after DHA/PPQ treatment. These findings raise concerns about the long-term efficacy of DHA/PPQ treatment in Africa. |
| first_indexed | 2024-12-11T02:28:37Z |
| format | Article |
| id | doaj.art-e2dc94e09a1f4a84960d1e3a39202c7c |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-11T02:28:37Z |
| publishDate | 2018-08-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-e2dc94e09a1f4a84960d1e3a39202c7c2022-12-22T01:23:53ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592018-08-012481591159310.3201/eid2408.180370Plasmodium falciparum Plasmepsin 2 Duplications, West AfricaJuliana InoueMiguel SilvaBakary FofanaKassim SanogoAndreas MårtenssonIssaka SagaraAnders BjörkmanMaria Isabel VeigaPedro Eduardo FerreiraAbdoulaye DjimdeJosé Pedro GilDihydroartemisinin/piperaquine (DHA/PPQ) is increasingly deployed as an antimalaria drug in Africa. We report the detection in Mali of Plasmodium falciparum infections carrying plasmepsin 2 duplications (associated with piperaquine resistance) in 7/65 recurrent infections within 2 months after DHA/PPQ treatment. These findings raise concerns about the long-term efficacy of DHA/PPQ treatment in Africa.https://wwwnc.cdc.gov/eid/article/24/8/18-0370_articlemalariapiperaquineresistancePlasmodium falciparumplasmepsin 2Pfpm2 |
| spellingShingle | Juliana Inoue Miguel Silva Bakary Fofana Kassim Sanogo Andreas Mårtensson Issaka Sagara Anders Björkman Maria Isabel Veiga Pedro Eduardo Ferreira Abdoulaye Djimde José Pedro Gil Plasmodium falciparum Plasmepsin 2 Duplications, West Africa Emerging Infectious Diseases malaria piperaquine resistance Plasmodium falciparum plasmepsin 2 Pfpm2 |
| title | Plasmodium falciparum Plasmepsin 2 Duplications, West Africa |
| title_full | Plasmodium falciparum Plasmepsin 2 Duplications, West Africa |
| title_fullStr | Plasmodium falciparum Plasmepsin 2 Duplications, West Africa |
| title_full_unstemmed | Plasmodium falciparum Plasmepsin 2 Duplications, West Africa |
| title_short | Plasmodium falciparum Plasmepsin 2 Duplications, West Africa |
| title_sort | plasmodium falciparum plasmepsin 2 duplications west africa |
| topic | malaria piperaquine resistance Plasmodium falciparum plasmepsin 2 Pfpm2 |
| url | https://wwwnc.cdc.gov/eid/article/24/8/18-0370_article |
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