Characteristics recurrence pattern of cholangiolocellular carcinoma as intrahepatic bile duct tumor growth following curative resection: a case report
Abstract Background Cholangiolocellular carcinoma (CoCC) is a rare primary liver tumor that shows mass-forming growth in most cases. At present, no effective treatment for hepatic recurrence CoCC has been established. We present a case involving a patient with recurrent disease that showed an intrad...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2019-09-01
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| Series: | Surgical Case Reports |
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| Online Access: | http://link.springer.com/article/10.1186/s40792-019-0698-2 |
| _version_ | 1831694844398927872 |
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| author | Keishi Hakoda Tomoyuki Abe Hironobu Amano Tomoyuki Minami Tsuyoshi Kobayashi Keiji Hanada Kenji Nishida Shuji Yonehara Masahiro Nakahara Hideki Ohdan Toshio Noriyuki |
| author_facet | Keishi Hakoda Tomoyuki Abe Hironobu Amano Tomoyuki Minami Tsuyoshi Kobayashi Keiji Hanada Kenji Nishida Shuji Yonehara Masahiro Nakahara Hideki Ohdan Toshio Noriyuki |
| author_sort | Keishi Hakoda |
| collection | DOAJ |
| description | Abstract Background Cholangiolocellular carcinoma (CoCC) is a rare primary liver tumor that shows mass-forming growth in most cases. At present, no effective treatment for hepatic recurrence CoCC has been established. We present a case involving a patient with recurrent disease that showed an intraductal growth (IG type) pattern of recurrence. The patient was treated with repeat hepatectomy with bile duct reconstruction. Case presentation The patient was a 76-year-old man with a history of S8 subsegmentectomy for CoCC. At 8 months after surgery, tumor marker elevation was observed. Computed tomography revealed a tumor occupying the right hepatic duct (B5-8) to B4 and the junction of the cystic duct. Endoscopic retrograde cholangiopancreatography (ERCP) and a thrombus biopsy with peroral cholangioscopy (POCS) confirmed the recurrence of CoCC in the intrahepatic bile duct. Although extended right lobectomy with extrahepatic bile duct resection was the optimal curative procedure, it was thought that it would be difficult due to his poor liver function. However, a slow-glowing recurrent tumor blocked the posterior branch of the portal vein; thus, the right liver lobe gradually shrank, and the estimated remnant liver volume increased in response, allowing curative surgery to finally be performed. At 10 months after surgery, the patient is alive without recurrence. Conclusions We reported a case of IG-type recurrence in the bile duct, which is an unusual pattern of intrahepatic recurrence, after initial surgery for CoCC. A slow-growing recurrent tumor exerted similar effects to PVE, which allowed for curative surgery to be performed. |
| first_indexed | 2024-12-20T12:42:29Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2198-7793 |
| language | English |
| last_indexed | 2024-12-20T12:42:29Z |
| publishDate | 2019-09-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj.art-e2dcafabf4b146ca90ec900c20ce205f2022-12-21T19:40:26ZengSpringerOpenSurgical Case Reports2198-77932019-09-01511510.1186/s40792-019-0698-2Characteristics recurrence pattern of cholangiolocellular carcinoma as intrahepatic bile duct tumor growth following curative resection: a case reportKeishi Hakoda0Tomoyuki Abe1Hironobu Amano2Tomoyuki Minami3Tsuyoshi Kobayashi4Keiji Hanada5Kenji Nishida6Shuji Yonehara7Masahiro Nakahara8Hideki Ohdan9Toshio Noriyuki10Department of Surgery, Onomichi General HospitalDepartment of Surgery, Onomichi General HospitalDepartment of Surgery, Onomichi General HospitalDepartment of Gastroenterology, Onomichi General HospitalDepartment of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima UniversityDepartment of Gastroenterology, Onomichi General HospitalDepartment of Pathology, Onomichi General HospitalDepartment of Pathology, Onomichi General HospitalDepartment of Surgery, Onomichi General HospitalDepartment of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima UniversityDepartment of Surgery, Onomichi General HospitalAbstract Background Cholangiolocellular carcinoma (CoCC) is a rare primary liver tumor that shows mass-forming growth in most cases. At present, no effective treatment for hepatic recurrence CoCC has been established. We present a case involving a patient with recurrent disease that showed an intraductal growth (IG type) pattern of recurrence. The patient was treated with repeat hepatectomy with bile duct reconstruction. Case presentation The patient was a 76-year-old man with a history of S8 subsegmentectomy for CoCC. At 8 months after surgery, tumor marker elevation was observed. Computed tomography revealed a tumor occupying the right hepatic duct (B5-8) to B4 and the junction of the cystic duct. Endoscopic retrograde cholangiopancreatography (ERCP) and a thrombus biopsy with peroral cholangioscopy (POCS) confirmed the recurrence of CoCC in the intrahepatic bile duct. Although extended right lobectomy with extrahepatic bile duct resection was the optimal curative procedure, it was thought that it would be difficult due to his poor liver function. However, a slow-glowing recurrent tumor blocked the posterior branch of the portal vein; thus, the right liver lobe gradually shrank, and the estimated remnant liver volume increased in response, allowing curative surgery to finally be performed. At 10 months after surgery, the patient is alive without recurrence. Conclusions We reported a case of IG-type recurrence in the bile duct, which is an unusual pattern of intrahepatic recurrence, after initial surgery for CoCC. A slow-growing recurrent tumor exerted similar effects to PVE, which allowed for curative surgery to be performed.http://link.springer.com/article/10.1186/s40792-019-0698-2Cholangiolocellular carcinomaNeoplasm local recurrenceHepatectomy |
| spellingShingle | Keishi Hakoda Tomoyuki Abe Hironobu Amano Tomoyuki Minami Tsuyoshi Kobayashi Keiji Hanada Kenji Nishida Shuji Yonehara Masahiro Nakahara Hideki Ohdan Toshio Noriyuki Characteristics recurrence pattern of cholangiolocellular carcinoma as intrahepatic bile duct tumor growth following curative resection: a case report Surgical Case Reports Cholangiolocellular carcinoma Neoplasm local recurrence Hepatectomy |
| title | Characteristics recurrence pattern of cholangiolocellular carcinoma as intrahepatic bile duct tumor growth following curative resection: a case report |
| title_full | Characteristics recurrence pattern of cholangiolocellular carcinoma as intrahepatic bile duct tumor growth following curative resection: a case report |
| title_fullStr | Characteristics recurrence pattern of cholangiolocellular carcinoma as intrahepatic bile duct tumor growth following curative resection: a case report |
| title_full_unstemmed | Characteristics recurrence pattern of cholangiolocellular carcinoma as intrahepatic bile duct tumor growth following curative resection: a case report |
| title_short | Characteristics recurrence pattern of cholangiolocellular carcinoma as intrahepatic bile duct tumor growth following curative resection: a case report |
| title_sort | characteristics recurrence pattern of cholangiolocellular carcinoma as intrahepatic bile duct tumor growth following curative resection a case report |
| topic | Cholangiolocellular carcinoma Neoplasm local recurrence Hepatectomy |
| url | http://link.springer.com/article/10.1186/s40792-019-0698-2 |
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