S-nitrosylation of CSF1 receptor increases the efficacy of CSF1R blockage against prostate cancer

S-nitrosylation of CSF1 receptor increases the efficacy of CSF1R blockage against prostate cancer

Abstract Sustained oxidative stress in castration-resistant prostate cancer (CRPC) cells potentiates the overall tumor microenvironment (TME). Targeting the TME using colony-stimulating factor 1 receptor (CSF1R) inhibition is a promising therapy for CRPC. However, the therapeutic response to sustain...

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Bibliographic Details
Main Authors: Fakiha Firdaus, Manish Kuchakulla, Rehana Qureshi, Raul Ariel Dulce, Yash Soni, Derek J. Van Booven, Khushi Shah, Thomas Masterson, Omar Joel Rosete, Sanoj Punnen, Joshua M. Hare, Ranjith Ramasamy, Himanshu Arora
Format: Article
Language:English
Published: Nature Publishing Group 2022-10-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05289-4

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