Plasmodium-specific atypical memory B cells are short-lived activated B cells
A subset of atypical memory B cells accumulates in malaria and several infections, autoimmune disorders and aging in both humans and mice. It has been suggested these cells are exhausted long-lived memory B cells, and their accumulation may contribute to poor acquisition of long-lasting immunity to...
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2018-11-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/39800 |
| _version_ | 1818019905892515840 |
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| author | Damián Pérez-Mazliah Peter J Gardner Edina Schweighoffer Sarah McLaughlin Caroline Hosking Irene Tumwine Randall S Davis Alexandre J Potocnik Victor LJ Tybulewicz Jean Langhorne |
| author_facet | Damián Pérez-Mazliah Peter J Gardner Edina Schweighoffer Sarah McLaughlin Caroline Hosking Irene Tumwine Randall S Davis Alexandre J Potocnik Victor LJ Tybulewicz Jean Langhorne |
| author_sort | Damián Pérez-Mazliah |
| collection | DOAJ |
| description | A subset of atypical memory B cells accumulates in malaria and several infections, autoimmune disorders and aging in both humans and mice. It has been suggested these cells are exhausted long-lived memory B cells, and their accumulation may contribute to poor acquisition of long-lasting immunity to certain chronic infections, such as malaria and HIV. Here, we generated an immunoglobulin heavy chain knock-in mouse with a BCR that recognizes MSP1 of the rodent malaria parasite, Plasmodium chabaudi. In combination with a mosquito-initiated P. chabaudi infection, we show that Plasmodium-specific atypical memory B cells are short-lived and disappear upon natural resolution of chronic infection. These cells show features of activation, proliferation, DNA replication, and plasmablasts. Our data demonstrate that Plasmodium-specific atypical memory B cells are not a subset of long-lived memory B cells, but rather short-lived activated cells, and part of a physiologic ongoing B-cell response. |
| first_indexed | 2024-04-14T07:58:00Z |
| format | Article |
| id | doaj.art-e2de577d888f4ca785c6b0bdd9c7749b |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-14T07:58:00Z |
| publishDate | 2018-11-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-e2de577d888f4ca785c6b0bdd9c7749b2022-12-22T02:04:58ZengeLife Sciences Publications LtdeLife2050-084X2018-11-01710.7554/eLife.39800Plasmodium-specific atypical memory B cells are short-lived activated B cellsDamián Pérez-Mazliah0https://orcid.org/0000-0002-2156-2585Peter J Gardner1https://orcid.org/0000-0002-4940-2639Edina Schweighoffer2Sarah McLaughlin3Caroline Hosking4Irene Tumwine5Randall S Davis6https://orcid.org/0000-0003-1906-8219Alexandre J Potocnik7https://orcid.org/0000-0002-4730-8593Victor LJ Tybulewicz8https://orcid.org/0000-0003-2439-0798Jean Langhorne9https://orcid.org/0000-0002-2257-9733The Francis Crick Institute, London, United KingdomMRC National Institute for Medical Research, London, United KingdomThe Francis Crick Institute, London, United KingdomThe Francis Crick Institute, London, United KingdomThe Francis Crick Institute, London, United KingdomThe Francis Crick Institute, London, United KingdomDepartment of Medicine, University of Alabama at Birmingham, Birmingham, United States; Department of Microbiology, University of Alabama at Birmingham, Birmingham, United States; Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, United StatesSchool of Biological Sciences, The University of Edinburgh, Edinburgh, United KingdomThe Francis Crick Institute, London, United KingdomThe Francis Crick Institute, London, United KingdomA subset of atypical memory B cells accumulates in malaria and several infections, autoimmune disorders and aging in both humans and mice. It has been suggested these cells are exhausted long-lived memory B cells, and their accumulation may contribute to poor acquisition of long-lasting immunity to certain chronic infections, such as malaria and HIV. Here, we generated an immunoglobulin heavy chain knock-in mouse with a BCR that recognizes MSP1 of the rodent malaria parasite, Plasmodium chabaudi. In combination with a mosquito-initiated P. chabaudi infection, we show that Plasmodium-specific atypical memory B cells are short-lived and disappear upon natural resolution of chronic infection. These cells show features of activation, proliferation, DNA replication, and plasmablasts. Our data demonstrate that Plasmodium-specific atypical memory B cells are not a subset of long-lived memory B cells, but rather short-lived activated cells, and part of a physiologic ongoing B-cell response.https://elifesciences.org/articles/39800atypical memory B cellsage-associated B cellsPlasmodiummalariamosquitoFCRL5 |
| spellingShingle | Damián Pérez-Mazliah Peter J Gardner Edina Schweighoffer Sarah McLaughlin Caroline Hosking Irene Tumwine Randall S Davis Alexandre J Potocnik Victor LJ Tybulewicz Jean Langhorne Plasmodium-specific atypical memory B cells are short-lived activated B cells eLife atypical memory B cells age-associated B cells Plasmodium malaria mosquito FCRL5 |
| title | Plasmodium-specific atypical memory B cells are short-lived activated B cells |
| title_full | Plasmodium-specific atypical memory B cells are short-lived activated B cells |
| title_fullStr | Plasmodium-specific atypical memory B cells are short-lived activated B cells |
| title_full_unstemmed | Plasmodium-specific atypical memory B cells are short-lived activated B cells |
| title_short | Plasmodium-specific atypical memory B cells are short-lived activated B cells |
| title_sort | plasmodium specific atypical memory b cells are short lived activated b cells |
| topic | atypical memory B cells age-associated B cells Plasmodium malaria mosquito FCRL5 |
| url | https://elifesciences.org/articles/39800 |
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