Disease-relevant β2-microglobulin variants share a common amyloid fold
The authors use cryo-EM to determine amyloid fibrils structures of disease relevant variants of β2-microglobulin in vitro. Each variant is polymorphic, but all polymorphs from all samples are built from a a lego-like assembly of common building blocks, suggesting a one amyloid fold’ paradigm.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36791-8 |
| _version_ | 1797864316848832512 |
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| author | Martin Wilkinson Rodrigo U. Gallardo Roberto Maya Martinez Nicolas Guthertz Masatomo So Liam D. Aubrey Sheena E. Radford Neil A. Ranson |
| author_facet | Martin Wilkinson Rodrigo U. Gallardo Roberto Maya Martinez Nicolas Guthertz Masatomo So Liam D. Aubrey Sheena E. Radford Neil A. Ranson |
| author_sort | Martin Wilkinson |
| collection | DOAJ |
| description | The authors use cryo-EM to determine amyloid fibrils structures of disease relevant variants of β2-microglobulin in vitro. Each variant is polymorphic, but all polymorphs from all samples are built from a a lego-like assembly of common building blocks, suggesting a one amyloid fold’ paradigm. |
| first_indexed | 2024-04-09T22:49:52Z |
| format | Article |
| id | doaj.art-e2de69dabe954fc29c63847d4f346f10 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T22:49:52Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e2de69dabe954fc29c63847d4f346f102023-03-22T11:41:41ZengNature PortfolioNature Communications2041-17232023-03-0114111510.1038/s41467-023-36791-8Disease-relevant β2-microglobulin variants share a common amyloid foldMartin Wilkinson0Rodrigo U. Gallardo1Roberto Maya Martinez2Nicolas Guthertz3Masatomo So4Liam D. Aubrey5Sheena E. Radford6Neil A. Ranson7Astbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of LeedsAstbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of LeedsAstbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of LeedsAstbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of LeedsAstbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of LeedsAstbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of LeedsAstbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of LeedsAstbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of LeedsThe authors use cryo-EM to determine amyloid fibrils structures of disease relevant variants of β2-microglobulin in vitro. Each variant is polymorphic, but all polymorphs from all samples are built from a a lego-like assembly of common building blocks, suggesting a one amyloid fold’ paradigm.https://doi.org/10.1038/s41467-023-36791-8 |
| spellingShingle | Martin Wilkinson Rodrigo U. Gallardo Roberto Maya Martinez Nicolas Guthertz Masatomo So Liam D. Aubrey Sheena E. Radford Neil A. Ranson Disease-relevant β2-microglobulin variants share a common amyloid fold Nature Communications |
| title | Disease-relevant β2-microglobulin variants share a common amyloid fold |
| title_full | Disease-relevant β2-microglobulin variants share a common amyloid fold |
| title_fullStr | Disease-relevant β2-microglobulin variants share a common amyloid fold |
| title_full_unstemmed | Disease-relevant β2-microglobulin variants share a common amyloid fold |
| title_short | Disease-relevant β2-microglobulin variants share a common amyloid fold |
| title_sort | disease relevant β2 microglobulin variants share a common amyloid fold |
| url | https://doi.org/10.1038/s41467-023-36791-8 |
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