pH-Sensitive Poly(acrylic acid)-g-poly(L-lysine) Charge-Driven Self-Assembling Hydrogels with 3D-Printability and Self-Healing Properties
We report the rheological behavior of aqueous solutions of a graft copolymer polyampholyte, constituted of polyacrylic acid (PAA) backbone grafted by Poly(L-lysine) (PAA-<i>b</i>-PLL). The graft copolymer self-assembles in aqueous media, forming a three-dimensional (3D) network through p...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/9/7/512 |
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| author | Maria-Eleni Kargaki Foteini Arfara Hermis Iatrou Constantinos Tsitsilianis |
| author_facet | Maria-Eleni Kargaki Foteini Arfara Hermis Iatrou Constantinos Tsitsilianis |
| author_sort | Maria-Eleni Kargaki |
| collection | DOAJ |
| description | We report the rheological behavior of aqueous solutions of a graft copolymer polyampholyte, constituted of polyacrylic acid (PAA) backbone grafted by Poly(L-lysine) (PAA-<i>b</i>-PLL). The graft copolymer self-assembles in aqueous media, forming a three-dimensional (3D) network through polyelectrolyte complexation of the oppositely charged PAA and PLL segments. Rheological investigations showed that the hydrogel exhibits interesting properties, namely, relatively low critical gel concentration, elastic response with slow dynamics, remarkable extended critical strain to flow, shear responsiveness, injectability, 3D printability and self-healing. Due to the weak nature of the involved polyelectrolyte segments, the hydrogel properties display pH-dependency, and they are affected by the presence of salt. Especially upon varying pH, the PLL secondary structure changes from random coil to <i>α</i>-helix, affecting the crosslinking structural mode and, in turn, the overall network structure as reflected in the rheological properties. Thanks to the biocompatibility of the copolymer constituents and the biodegradability of PLL, the designed gelator seems to exhibit potential for bioapplications. |
| first_indexed | 2024-03-11T01:04:08Z |
| format | Article |
| id | doaj.art-e2de89dc6d2948c09b915f6b0ee55232 |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-11T01:04:08Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-e2de89dc6d2948c09b915f6b0ee552322023-11-18T19:27:09ZengMDPI AGGels2310-28612023-06-019751210.3390/gels9070512pH-Sensitive Poly(acrylic acid)-g-poly(L-lysine) Charge-Driven Self-Assembling Hydrogels with 3D-Printability and Self-Healing PropertiesMaria-Eleni Kargaki0Foteini Arfara1Hermis Iatrou2Constantinos Tsitsilianis3Department of Chemical Engineering, University of Patras, 26500 Patras, GreeceDepartment of Chemistry, University of Athens, Panepistimiopolis, Zografou, 15771 Athens, GreeceDepartment of Chemistry, University of Athens, Panepistimiopolis, Zografou, 15771 Athens, GreeceDepartment of Chemical Engineering, University of Patras, 26500 Patras, GreeceWe report the rheological behavior of aqueous solutions of a graft copolymer polyampholyte, constituted of polyacrylic acid (PAA) backbone grafted by Poly(L-lysine) (PAA-<i>b</i>-PLL). The graft copolymer self-assembles in aqueous media, forming a three-dimensional (3D) network through polyelectrolyte complexation of the oppositely charged PAA and PLL segments. Rheological investigations showed that the hydrogel exhibits interesting properties, namely, relatively low critical gel concentration, elastic response with slow dynamics, remarkable extended critical strain to flow, shear responsiveness, injectability, 3D printability and self-healing. Due to the weak nature of the involved polyelectrolyte segments, the hydrogel properties display pH-dependency, and they are affected by the presence of salt. Especially upon varying pH, the PLL secondary structure changes from random coil to <i>α</i>-helix, affecting the crosslinking structural mode and, in turn, the overall network structure as reflected in the rheological properties. Thanks to the biocompatibility of the copolymer constituents and the biodegradability of PLL, the designed gelator seems to exhibit potential for bioapplications.https://www.mdpi.com/2310-2861/9/7/512hydrogelpoly(acrylic acid)-<i>g</i>-poly(L-lysine)self-assemble3D-networkshear-induced 3D printabilitypH sensitivity |
| spellingShingle | Maria-Eleni Kargaki Foteini Arfara Hermis Iatrou Constantinos Tsitsilianis pH-Sensitive Poly(acrylic acid)-g-poly(L-lysine) Charge-Driven Self-Assembling Hydrogels with 3D-Printability and Self-Healing Properties Gels hydrogel poly(acrylic acid)-<i>g</i>-poly(L-lysine) self-assemble 3D-network shear-induced 3D printability pH sensitivity |
| title | pH-Sensitive Poly(acrylic acid)-g-poly(L-lysine) Charge-Driven Self-Assembling Hydrogels with 3D-Printability and Self-Healing Properties |
| title_full | pH-Sensitive Poly(acrylic acid)-g-poly(L-lysine) Charge-Driven Self-Assembling Hydrogels with 3D-Printability and Self-Healing Properties |
| title_fullStr | pH-Sensitive Poly(acrylic acid)-g-poly(L-lysine) Charge-Driven Self-Assembling Hydrogels with 3D-Printability and Self-Healing Properties |
| title_full_unstemmed | pH-Sensitive Poly(acrylic acid)-g-poly(L-lysine) Charge-Driven Self-Assembling Hydrogels with 3D-Printability and Self-Healing Properties |
| title_short | pH-Sensitive Poly(acrylic acid)-g-poly(L-lysine) Charge-Driven Self-Assembling Hydrogels with 3D-Printability and Self-Healing Properties |
| title_sort | ph sensitive poly acrylic acid g poly l lysine charge driven self assembling hydrogels with 3d printability and self healing properties |
| topic | hydrogel poly(acrylic acid)-<i>g</i>-poly(L-lysine) self-assemble 3D-network shear-induced 3D printability pH sensitivity |
| url | https://www.mdpi.com/2310-2861/9/7/512 |
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