Retinoic Acid Grafted to Hyaluronic Acid Activates Retinoid Gene Expression and Removes Cholesterol from Cellular Membranes

Retinoic Acid Grafted to Hyaluronic Acid Activates Retinoid Gene Expression and Removes Cholesterol from Cellular Membranes

All-trans-retinoic acid (atRA) is a potent ligand that regulates gene expression and is used to treat several skin disorders. Hyaluronic acid (HA) was previously conjugated with atRA (HA-atRA) to obtain a novel amphiphilic compound. HA-atRA forms micelles that incorporate hydrophobic molecules and f...

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Bibliographic Details
Main Authors: Vojtěch Pavlík, Veronika Machalová, Martin Čepa, Romana Šínová, Barbora Šafránková, Jaromír Kulhánek, Tomáš Drmota, Lukáš Kubala, Gloria Huerta-Ángeles, Vladimír Velebný, Kristina Nešporová
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Biomolecules
Subjects:
retinoic acid
hyaluronic acid
amphiphilic hyaluronan
nanocarrier
cholesterol
HyRetin
Online Access:https://www.mdpi.com/2218-273X/12/2/200

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