Maternal genetic polymorphisms in the major mitotic checkpoint genes MAD1L1 and MAD2L1 associated with the risk of survival in abnormal chromosomal fetuses

Maternal genetic polymorphisms in the major mitotic checkpoint genes MAD1L1 and MAD2L1 associated with the risk of survival in abnormal chromosomal fetuses

Background: The genetic etiology of fetal chromosome abnormalities remains unknown, which brings about an enormous burden for patients, families, and society. The spindle assembly checkpoint (SAC) controls the normal procedure of chromosome disjunction and may take part in the process.Objective: The...

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Bibliographic Details
Main Authors: Ying Chan, Yize Liu, Yamin Kong, Weiming Xu, Xiaohong Zeng, Haichun Li, Yan Guo, Xinhua Tang, Jinman Zhang, Baosheng Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Genetics
Subjects:
MAD1L1
MAD2L1
homocysteine(HYC)
fetal chromosome abnormality
polymorphism
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2023.1105184/full

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