Treatment Outcome of Tuberculosis in Patients with Diabetes under RNTCP in a Tertiary Care Centre, Chengalpattu, India: A Prospective Cohort Study
Introduction: Diabetes increases the risk of Tuberculosis (TB) by three times, and this bidirectional association is currently one of the major concerns. A stronger evidence base is required to clarify the impact of Diabetes Mellitus (DM) on the treatment outcome of TB. Aim: To compare the trea...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2023-09-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://www.jcdr.net/articles/PDF/18475/64830_CE[Ra1]_F(IS)_QC(KK_OM)_PF1(AG_OM)_PFA(OM_KM)_PB(AG_KM)_PN(KM).pdf |
| Summary: | Introduction: Diabetes increases the risk of Tuberculosis (TB)
by three times, and this bidirectional association is currently
one of the major concerns. A stronger evidence base is required
to clarify the impact of Diabetes Mellitus (DM) on the treatment
outcome of TB.
Aim: To compare the treatment outcome among diabetic and
non diabetic patients on Category-I TB treatment based on the
Revised National Tuberculosis Control Program (RNTCP). Also,
to assess the various factors influencing the treatment outcome
of TB among diabetic patients.
Material and Methods: A prospective cohort study was
conducted on 75 newly diagnosed TB patients enrolled for
Category-I treatment Department of Pulmonary Medicine,
Chengalpattu Medical College, Chengalpattu, Tamil Nadu, India,
between October 2018 to November 2019. All patients with TB
underwent blood glucose screening at treatment initiation and
were categorised into two groups: with diabetes and without
diabetes. Demographic details, family history of DM, smoking,
alcohol consumption, and clinical profile were collected using a
semi-structured questionnaire and followed-up for six months
to assess their treatment outcome. The treatment outcome
was compared statistically based on diabetes status using the
Chi-square test.
Results: The mean age of the study population was 49.9±0.5
years, with the majority being male 56 (74.7%). More than half of
the study population belonged to a low socio-economic status.
Among the study population, 42 (56%) were diabetic, with a mean
blood glucose level of 242.7±80.5 mg/dL. Eighty-two percent had
Pulmonary TB, with a 68% smear positivity rate among diabetic
patients. In terms of treatment outcome, 44 (58.7%) were cured,
15 (20%) completed treatment, 10 (13.3%) were lost to followup, and 6 (8%) expired during the treatment course.
Conclusion: Smear positivity and pulmonary TB were predominant
among patients with diabetes. Treatment completion was lower,
and mortality was higher among diabetic patients with TB. |
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| ISSN: | 2249-782X 0973-709X |