Drug release study of the chitosan-based nanoparticles
Recently, multifunctional drug delivery systems (DDSs) have been designed to provide a comprehensive approach with multiple functionalities, including diagnostic imaging, targeted drug delivery, and controlled drug release. Chitosan-based drug nanoparticles (CSNPs) systems are employed as diagnostic...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844021027778 |
| _version_ | 1798018016744570880 |
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| author | Yedi Herdiana Nasrul Wathoni Shaharum Shamsuddin Muchtaridi Muchtaridi |
| author_facet | Yedi Herdiana Nasrul Wathoni Shaharum Shamsuddin Muchtaridi Muchtaridi |
| author_sort | Yedi Herdiana |
| collection | DOAJ |
| description | Recently, multifunctional drug delivery systems (DDSs) have been designed to provide a comprehensive approach with multiple functionalities, including diagnostic imaging, targeted drug delivery, and controlled drug release. Chitosan-based drug nanoparticles (CSNPs) systems are employed as diagnostic imaging and delivering the drug to particular targeted sites in a regulated manner. Drug release is an important factor in ensuring high reproducibility, stability, quality control of CSNPs, and scientific-based for developing CSNPs. Several factors influence drug release from CSNPs, including composition, composition ratio, ingredient interactions, and preparation methods. Early, CSNPs were used for improving drug solubility, stability, pharmacokinetics, and pharmacotherapeutics properties. Chitosan has been developed toward a multifunctional drug delivery system by exploring positively charged properties and modifiable functional groups. Various modifications to the polymer backbone, charge, or functional groups will undoubtedly affect the drug release from CSNPs. The drug release from CSNPs has a significant influence on its therapeutic actions. Our review's objective was to summarize and discuss the relationship between the modification in CSNPs as multifunctional delivery systems and drug release properties and kinetics of the drug release model. Kinetic models help describe the release rate, leading to increased efficiency, accuracy, the safety of the dose, optimizing the drug delivery device's design, evaluating the drug release rate, and improvement of patient compatibility. In conclusion, almost all CSNPs showed bi-phasic release, initial burst release drug in a particular time followed controlled manner release in achieving the expected release, stimuli external can be applied. CSNPs are a promising technique for multifunctional drug delivery systems. |
| first_indexed | 2024-04-11T16:16:53Z |
| format | Article |
| id | doaj.art-e2e7801c73b64bd999e31479b0d2d14f |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-11T16:16:53Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-e2e7801c73b64bd999e31479b0d2d14f2022-12-22T04:14:30ZengElsevierHeliyon2405-84402022-01-0181e08674Drug release study of the chitosan-based nanoparticlesYedi Herdiana0Nasrul Wathoni1Shaharum Shamsuddin2Muchtaridi Muchtaridi3Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, 45363, IndonesiaDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, 45363, Indonesia; Functional Nano Powder University Center of Excellence (FiNder U CoE), Universitas Padjadjaran, IndonesiaSchool of Health Sciences, Universiti Sains Malaysia, 16150, Kubang Kerian, Kelantan, Malaysia; USM-RIKEN Interdisciplinary Collaboration on Advanced Sciences (URICAS), 11800, USM, Penang, MalaysiaDepartment of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, 45363, Indonesia; Functional Nano Powder University Center of Excellence (FiNder U CoE), Universitas Padjadjaran, Indonesia; Corresponding author.Recently, multifunctional drug delivery systems (DDSs) have been designed to provide a comprehensive approach with multiple functionalities, including diagnostic imaging, targeted drug delivery, and controlled drug release. Chitosan-based drug nanoparticles (CSNPs) systems are employed as diagnostic imaging and delivering the drug to particular targeted sites in a regulated manner. Drug release is an important factor in ensuring high reproducibility, stability, quality control of CSNPs, and scientific-based for developing CSNPs. Several factors influence drug release from CSNPs, including composition, composition ratio, ingredient interactions, and preparation methods. Early, CSNPs were used for improving drug solubility, stability, pharmacokinetics, and pharmacotherapeutics properties. Chitosan has been developed toward a multifunctional drug delivery system by exploring positively charged properties and modifiable functional groups. Various modifications to the polymer backbone, charge, or functional groups will undoubtedly affect the drug release from CSNPs. The drug release from CSNPs has a significant influence on its therapeutic actions. Our review's objective was to summarize and discuss the relationship between the modification in CSNPs as multifunctional delivery systems and drug release properties and kinetics of the drug release model. Kinetic models help describe the release rate, leading to increased efficiency, accuracy, the safety of the dose, optimizing the drug delivery device's design, evaluating the drug release rate, and improvement of patient compatibility. In conclusion, almost all CSNPs showed bi-phasic release, initial burst release drug in a particular time followed controlled manner release in achieving the expected release, stimuli external can be applied. CSNPs are a promising technique for multifunctional drug delivery systems.http://www.sciencedirect.com/science/article/pii/S2405844021027778Multifunction delivery systemBi-phasic releaseBurst releaseControlled release |
| spellingShingle | Yedi Herdiana Nasrul Wathoni Shaharum Shamsuddin Muchtaridi Muchtaridi Drug release study of the chitosan-based nanoparticles Heliyon Multifunction delivery system Bi-phasic release Burst release Controlled release |
| title | Drug release study of the chitosan-based nanoparticles |
| title_full | Drug release study of the chitosan-based nanoparticles |
| title_fullStr | Drug release study of the chitosan-based nanoparticles |
| title_full_unstemmed | Drug release study of the chitosan-based nanoparticles |
| title_short | Drug release study of the chitosan-based nanoparticles |
| title_sort | drug release study of the chitosan based nanoparticles |
| topic | Multifunction delivery system Bi-phasic release Burst release Controlled release |
| url | http://www.sciencedirect.com/science/article/pii/S2405844021027778 |
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