Effects of Benzene: Hematological and Hypersensitivity Manifestations in Resident Living in Oil Refinery Areas
Literature is teeming with publications on industrial pollution. Over the decades, the main industrial pollutants and their effects on human health have been widely framed. Among the various compounds involved, benzene plays a leading role in the onset of specific diseases. Two systems are mainly af...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Toxics |
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| Online Access: | https://www.mdpi.com/2305-6304/10/11/678 |
| _version_ | 1797466418095063040 |
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| author | Raffaele Cordiano Vincenzo Papa Nicola Cicero Giovanna Spatari Alessandro Allegra Sebastiano Gangemi |
| author_facet | Raffaele Cordiano Vincenzo Papa Nicola Cicero Giovanna Spatari Alessandro Allegra Sebastiano Gangemi |
| author_sort | Raffaele Cordiano |
| collection | DOAJ |
| description | Literature is teeming with publications on industrial pollution. Over the decades, the main industrial pollutants and their effects on human health have been widely framed. Among the various compounds involved, benzene plays a leading role in the onset of specific diseases. Two systems are mainly affected by the adverse health effects of benzene exposure, both acute and chronic: the respiratory and hematopoietic systems. The most suitable population targets for a proper damage assessment on these systems are oil refinery workers and residents near refining plants. Our work fits into this area of interest with the aim of reviewing the most relevant cases published in the literature related to the impairment of the aforementioned systems following benzene exposure. We perform an initial debate between the two clinical branches that see a high epidemiological expression in this slice of the population examined: residents near petroleum refinery areas worldwide. In addition, the discussion expands on highlighting the main immunological implications of benzene exposure, finding a common pathophysiological denominator in inflammation, oxidative stress, and DNA damage, thus helping to set the basis for an increasingly detailed characterization aimed at identifying common molecular patterns between the two clinical fields discussed. |
| first_indexed | 2024-03-09T18:35:42Z |
| format | Article |
| id | doaj.art-e2e7a1b520304e93bd2a05b297a47f97 |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-09T18:35:42Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-e2e7a1b520304e93bd2a05b297a47f972023-11-24T07:10:09ZengMDPI AGToxics2305-63042022-11-01101167810.3390/toxics10110678Effects of Benzene: Hematological and Hypersensitivity Manifestations in Resident Living in Oil Refinery AreasRaffaele Cordiano0Vincenzo Papa1Nicola Cicero2Giovanna Spatari3Alessandro Allegra4Sebastiano Gangemi5Department of Clinical and Experimental Medicine, School and Operative Unit of Allergy and Clinical Immunology, University of Messina, 98125 Messina, ItalyDepartment of Clinical and Experimental Medicine, School and Operative Unit of Allergy and Clinical Immunology, University of Messina, 98125 Messina, ItalyDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98168 Messina, ItalyDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98168 Messina, ItalyDivision of Hematology, Department of Human Pathology in Adulthood and Childhood “Gaetano Barresi”, University of Messina, 98125 Messina, ItalyDepartment of Clinical and Experimental Medicine, School and Operative Unit of Allergy and Clinical Immunology, University of Messina, 98125 Messina, ItalyLiterature is teeming with publications on industrial pollution. Over the decades, the main industrial pollutants and their effects on human health have been widely framed. Among the various compounds involved, benzene plays a leading role in the onset of specific diseases. Two systems are mainly affected by the adverse health effects of benzene exposure, both acute and chronic: the respiratory and hematopoietic systems. The most suitable population targets for a proper damage assessment on these systems are oil refinery workers and residents near refining plants. Our work fits into this area of interest with the aim of reviewing the most relevant cases published in the literature related to the impairment of the aforementioned systems following benzene exposure. We perform an initial debate between the two clinical branches that see a high epidemiological expression in this slice of the population examined: residents near petroleum refinery areas worldwide. In addition, the discussion expands on highlighting the main immunological implications of benzene exposure, finding a common pathophysiological denominator in inflammation, oxidative stress, and DNA damage, thus helping to set the basis for an increasingly detailed characterization aimed at identifying common molecular patterns between the two clinical fields discussed.https://www.mdpi.com/2305-6304/10/11/678benzeneVOCsenvironmental pollutantspetrochemical plantshematologic malignanciespetroleum refineries |
| spellingShingle | Raffaele Cordiano Vincenzo Papa Nicola Cicero Giovanna Spatari Alessandro Allegra Sebastiano Gangemi Effects of Benzene: Hematological and Hypersensitivity Manifestations in Resident Living in Oil Refinery Areas Toxics benzene VOCs environmental pollutants petrochemical plants hematologic malignancies petroleum refineries |
| title | Effects of Benzene: Hematological and Hypersensitivity Manifestations in Resident Living in Oil Refinery Areas |
| title_full | Effects of Benzene: Hematological and Hypersensitivity Manifestations in Resident Living in Oil Refinery Areas |
| title_fullStr | Effects of Benzene: Hematological and Hypersensitivity Manifestations in Resident Living in Oil Refinery Areas |
| title_full_unstemmed | Effects of Benzene: Hematological and Hypersensitivity Manifestations in Resident Living in Oil Refinery Areas |
| title_short | Effects of Benzene: Hematological and Hypersensitivity Manifestations in Resident Living in Oil Refinery Areas |
| title_sort | effects of benzene hematological and hypersensitivity manifestations in resident living in oil refinery areas |
| topic | benzene VOCs environmental pollutants petrochemical plants hematologic malignancies petroleum refineries |
| url | https://www.mdpi.com/2305-6304/10/11/678 |
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