Paracrine Crosstalk between Fibroblasts and ER+ Breast Cancer Cells Creates an IL1β-Enriched Niche that Promotes Tumor Growth

Paracrine Crosstalk between Fibroblasts and ER+ Breast Cancer Cells Creates an IL1β-Enriched Niche that Promotes Tumor Growth

Summary: Breast cancer-induced activated fibroblasts support tumor progression. However, the role of normal fibroblasts in tumor progression remains controversial. In this study, we used modified patient-derived organoid cultures and demonstrate that constitutively secreted cytokines from normal bre...

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Bibliographic Details
Main Authors: Sumanta Chatterjee, Vasudeva Bhat, Alexei Berdnikov, Jiahui Liu, Guihua Zhang, Edward Buchel, Janice Safneck, Aaron J. Marshall, Leigh C. Murphy, Lynne-Marie Postovit, Afshin Raouf
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004219302615

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