Reference intervals for thyroid hormones for the elderly population and their influence on the diagnosis of subclinical hypothyroidism
Background: This study aims to establish reference intervals (RIs) for thyroid hormones in the elderly population and analyze their influence on the prevalence of subclinical hypothyroidism. Methods: Thyroid hormone records of subjects who underwent routine health checkup at our hospital between 201...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Society of Medical Biochemists of Serbia, Belgrade
2023-01-01
|
| Series: | Journal of Medical Biochemistry |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2023/1452-82582302258F.pdf |
| _version_ | 1797853214586961920 |
|---|---|
| author | Fu Jingxuan Wang Yidan Liu Yunyi Song Qinfei Cao Jingrong Peichang Wang |
| author_facet | Fu Jingxuan Wang Yidan Liu Yunyi Song Qinfei Cao Jingrong Peichang Wang |
| author_sort | Fu Jingxuan |
| collection | DOAJ |
| description | Background: This study aims to establish reference intervals (RIs) for thyroid hormones in the elderly population and analyze their influence on the prevalence of subclinical hypothyroidism. Methods: Thyroid hormone records of subjects who underwent routine health checkup at our hospital between 2018 and 2020 were analyzed. Thyroid stimulating hormone (TSH), total triiodothyronine, total thyroxine, free triiodothyronine (FT3), and free thyroxine (FT4) levels were compared between young and elderly subjects. Thresholds of these thyroid hormones were established for elderly subjects. Results: A total of 22,207 subjects were included. Of them, 2,254 (10.15%) were aged ≥ 65 years. Elderly subjects had higher TSH, and lower FT3 and FT4 levels when compared with young subjects. In the elderly group, the RIs for TSH, FT3 and FT4 were 0.55-5.14 mIU/L, 3.68-5.47 pmol/L, and 12.00-19.87 pmol/L, respectively. The age and sex specific RIs for TSH were 0.56-5.07 mIU/L for men and 0.51-5.25 mIU/L for women. With whole-group RIs and age and sex-specific RIs for elderly people, the prevalence of subclinical hypothyroidism was 9.83% and 6.29% (p < 0.001), respectively. Conclusions: Elderly individuals had higher TSH levels than young individuals. Our study indicated that establishing specific RIs for elderly individuals is needed. This has implications for the diagnosis and management of subclinical hypothyroidism in the elderly population. |
| first_indexed | 2024-04-09T19:47:01Z |
| format | Article |
| id | doaj.art-e2ec3b20fabb40c78bbd58d4caf42269 |
| institution | Directory Open Access Journal |
| issn | 1452-8258 1452-8266 |
| language | English |
| last_indexed | 2024-04-09T19:47:01Z |
| publishDate | 2023-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj.art-e2ec3b20fabb40c78bbd58d4caf422692023-04-03T15:53:00ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662023-01-014222582641452-82582302258FReference intervals for thyroid hormones for the elderly population and their influence on the diagnosis of subclinical hypothyroidismFu Jingxuan0Wang Yidan1Liu Yunyi2Song Qinfei3Cao Jingrong4Peichang Wang5Capital Medical University, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Department of Clinical Laboratory, Beijing, ChinaCapital Medical University, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Department of Clinical Laboratory, Beijing, ChinaCapital Medical University, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Department of Clinical Laboratory, Beijing, ChinaCapital Medical University, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Department of Clinical Laboratory, Beijing, ChinaCapital Medical University, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Department of Clinical Laboratory, Beijing, ChinaCapital Medical University, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Department of Clinical Laboratory, Beijing, ChinaBackground: This study aims to establish reference intervals (RIs) for thyroid hormones in the elderly population and analyze their influence on the prevalence of subclinical hypothyroidism. Methods: Thyroid hormone records of subjects who underwent routine health checkup at our hospital between 2018 and 2020 were analyzed. Thyroid stimulating hormone (TSH), total triiodothyronine, total thyroxine, free triiodothyronine (FT3), and free thyroxine (FT4) levels were compared between young and elderly subjects. Thresholds of these thyroid hormones were established for elderly subjects. Results: A total of 22,207 subjects were included. Of them, 2,254 (10.15%) were aged ≥ 65 years. Elderly subjects had higher TSH, and lower FT3 and FT4 levels when compared with young subjects. In the elderly group, the RIs for TSH, FT3 and FT4 were 0.55-5.14 mIU/L, 3.68-5.47 pmol/L, and 12.00-19.87 pmol/L, respectively. The age and sex specific RIs for TSH were 0.56-5.07 mIU/L for men and 0.51-5.25 mIU/L for women. With whole-group RIs and age and sex-specific RIs for elderly people, the prevalence of subclinical hypothyroidism was 9.83% and 6.29% (p < 0.001), respectively. Conclusions: Elderly individuals had higher TSH levels than young individuals. Our study indicated that establishing specific RIs for elderly individuals is needed. This has implications for the diagnosis and management of subclinical hypothyroidism in the elderly population.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2023/1452-82582302258F.pdfsubclinical hypothyroidismelderlythyroid hormonesreference intervals |
| spellingShingle | Fu Jingxuan Wang Yidan Liu Yunyi Song Qinfei Cao Jingrong Peichang Wang Reference intervals for thyroid hormones for the elderly population and their influence on the diagnosis of subclinical hypothyroidism Journal of Medical Biochemistry subclinical hypothyroidism elderly thyroid hormones reference intervals |
| title | Reference intervals for thyroid hormones for the elderly population and their influence on the diagnosis of subclinical hypothyroidism |
| title_full | Reference intervals for thyroid hormones for the elderly population and their influence on the diagnosis of subclinical hypothyroidism |
| title_fullStr | Reference intervals for thyroid hormones for the elderly population and their influence on the diagnosis of subclinical hypothyroidism |
| title_full_unstemmed | Reference intervals for thyroid hormones for the elderly population and their influence on the diagnosis of subclinical hypothyroidism |
| title_short | Reference intervals for thyroid hormones for the elderly population and their influence on the diagnosis of subclinical hypothyroidism |
| title_sort | reference intervals for thyroid hormones for the elderly population and their influence on the diagnosis of subclinical hypothyroidism |
| topic | subclinical hypothyroidism elderly thyroid hormones reference intervals |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2023/1452-82582302258F.pdf |
| work_keys_str_mv | AT fujingxuan referenceintervalsforthyroidhormonesfortheelderlypopulationandtheirinfluenceonthediagnosisofsubclinicalhypothyroidism AT wangyidan referenceintervalsforthyroidhormonesfortheelderlypopulationandtheirinfluenceonthediagnosisofsubclinicalhypothyroidism AT liuyunyi referenceintervalsforthyroidhormonesfortheelderlypopulationandtheirinfluenceonthediagnosisofsubclinicalhypothyroidism AT songqinfei referenceintervalsforthyroidhormonesfortheelderlypopulationandtheirinfluenceonthediagnosisofsubclinicalhypothyroidism AT caojingrong referenceintervalsforthyroidhormonesfortheelderlypopulationandtheirinfluenceonthediagnosisofsubclinicalhypothyroidism AT peichangwang referenceintervalsforthyroidhormonesfortheelderlypopulationandtheirinfluenceonthediagnosisofsubclinicalhypothyroidism |