Relationship between Serum Homocysteine Concentration and Dietary Factors in Young Japanese Women
Homocysteine is a methionine metabolism intermediate and its increased blood levels are associated with a higher risk of noncommunicable diseases. Reportedly, blood homocysteine levels increase with inadequate folate, vitamin B<sub>6</sub>, and vitamin B<sub>12</sub> intake;...
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MDPI AG
2023-11-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/22/4740 |
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| author | Akiko Tajima Yoshinori Kubo Sayaka Horiguchi Kumiko Shoji Terue Kawabata |
| author_facet | Akiko Tajima Yoshinori Kubo Sayaka Horiguchi Kumiko Shoji Terue Kawabata |
| author_sort | Akiko Tajima |
| collection | DOAJ |
| description | Homocysteine is a methionine metabolism intermediate and its increased blood levels are associated with a higher risk of noncommunicable diseases. Reportedly, blood homocysteine levels increase with inadequate folate, vitamin B<sub>6</sub>, and vitamin B<sub>12</sub> intake; however, its relationship with dietary factors other than these three vitamins remains unknown. Thus, we investigated the relationship of homocysteine with other nutrient intake. We performed a dietary survey on 227 young women using a food record with approximate amounts for 7 consecutive days in conjunction with digital imaging. We collected early morning fasting blood samples the day after the dietary survey was completed and analyzed the serum homocysteine levels. We observed that the serum homocysteine concentrations were significantly negatively associated with soluble, insoluble, and total fiber intake. In addition, participants with high fruit and mushroom intake displayed lower serum homocysteine concentrations, suggesting dietary fiber involvement from these foods. However, we observed no serum homocysteine concentration-related association with cereals and vegetables (well-documented dietary fiber sources) or with fruits and mushrooms. In conclusion, fiber quality-related differences could thus be caused by different sources, including antioxidant components such as fruit polyphenols and mushroom antioxidant and anti-inflammatory factors. |
| first_indexed | 2024-03-09T16:33:49Z |
| format | Article |
| id | doaj.art-e2ef9382e5ac471c9c0a2f6a5e27efaa |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T16:33:49Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-e2ef9382e5ac471c9c0a2f6a5e27efaa2023-11-24T14:59:09ZengMDPI AGNutrients2072-66432023-11-011522474010.3390/nu15224740Relationship between Serum Homocysteine Concentration and Dietary Factors in Young Japanese WomenAkiko Tajima0Yoshinori Kubo1Sayaka Horiguchi2Kumiko Shoji3Terue Kawabata4Faculty of Nutrition, Kagawa Nutrition University, 3-9-21 Chiyoda, Sakado 350-0288, Saitama, JapanDivision of Anatomy and Cell Biology, Department of Anatomy, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu 520-2192, Shiga, JapanFaculty of Nutrition, Kagawa Nutrition University, 3-9-21 Chiyoda, Sakado 350-0288, Saitama, JapanFaculty of Nutrition, Kagawa Nutrition University, 3-9-21 Chiyoda, Sakado 350-0288, Saitama, JapanFaculty of Nutrition, Kagawa Nutrition University, 3-9-21 Chiyoda, Sakado 350-0288, Saitama, JapanHomocysteine is a methionine metabolism intermediate and its increased blood levels are associated with a higher risk of noncommunicable diseases. Reportedly, blood homocysteine levels increase with inadequate folate, vitamin B<sub>6</sub>, and vitamin B<sub>12</sub> intake; however, its relationship with dietary factors other than these three vitamins remains unknown. Thus, we investigated the relationship of homocysteine with other nutrient intake. We performed a dietary survey on 227 young women using a food record with approximate amounts for 7 consecutive days in conjunction with digital imaging. We collected early morning fasting blood samples the day after the dietary survey was completed and analyzed the serum homocysteine levels. We observed that the serum homocysteine concentrations were significantly negatively associated with soluble, insoluble, and total fiber intake. In addition, participants with high fruit and mushroom intake displayed lower serum homocysteine concentrations, suggesting dietary fiber involvement from these foods. However, we observed no serum homocysteine concentration-related association with cereals and vegetables (well-documented dietary fiber sources) or with fruits and mushrooms. In conclusion, fiber quality-related differences could thus be caused by different sources, including antioxidant components such as fruit polyphenols and mushroom antioxidant and anti-inflammatory factors.https://www.mdpi.com/2072-6643/15/22/4740homocysteinedietary fibersoluble fiberinsoluble fiberfruitsmushrooms |
| spellingShingle | Akiko Tajima Yoshinori Kubo Sayaka Horiguchi Kumiko Shoji Terue Kawabata Relationship between Serum Homocysteine Concentration and Dietary Factors in Young Japanese Women Nutrients homocysteine dietary fiber soluble fiber insoluble fiber fruits mushrooms |
| title | Relationship between Serum Homocysteine Concentration and Dietary Factors in Young Japanese Women |
| title_full | Relationship between Serum Homocysteine Concentration and Dietary Factors in Young Japanese Women |
| title_fullStr | Relationship between Serum Homocysteine Concentration and Dietary Factors in Young Japanese Women |
| title_full_unstemmed | Relationship between Serum Homocysteine Concentration and Dietary Factors in Young Japanese Women |
| title_short | Relationship between Serum Homocysteine Concentration and Dietary Factors in Young Japanese Women |
| title_sort | relationship between serum homocysteine concentration and dietary factors in young japanese women |
| topic | homocysteine dietary fiber soluble fiber insoluble fiber fruits mushrooms |
| url | https://www.mdpi.com/2072-6643/15/22/4740 |
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