Autophagy-mediated NKG2D internalization impairs NK cell function and exacerbates radiation pneumonitis

Autophagy-mediated NKG2D internalization impairs NK cell function and exacerbates radiation pneumonitis

IntroductionRadiation pneumonitis is a critical complication that constrains the use of radiation therapy for thoracic malignancies, leading to substantial morbidity via respiratory distress and lung function impairment. The role of Natural killer (NK) cells in inflammatory diseases is well-document...

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Bibliographic Details
Main Authors: Ruiqing Wang, Xinyue Ma, Xinyu Zhang, Dizhi Jiang, Hongyuan Mao, Zerun Li, Yu Tian, Bo Cheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Immunology
Subjects:
radiation pneumonitis
CXCL10/CXCR3
autophagy
NKG2D
NK cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1250920/full

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