Magnesium alloys for orthopedic applications:A review on the mechanisms driving bone healing
Magnesium (Mg) alloys have attracted a wealth of attention in orthopedic fields for their superior mechanical properties, degradability, and excellent biocompatibility. Consistently, to resolve the issues on rapid degradation, more studies are dedicated to the researches on the composition design, p...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2022-12-01
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| Series: | Journal of Magnesium and Alloys |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213956722003012 |
| _version_ | 1797204016649732096 |
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| author | Ning Wang Shude Yang Huixin Shi Yiping Song Hui Sun Qiang Wang Lili Tan Shu Guo |
| author_facet | Ning Wang Shude Yang Huixin Shi Yiping Song Hui Sun Qiang Wang Lili Tan Shu Guo |
| author_sort | Ning Wang |
| collection | DOAJ |
| description | Magnesium (Mg) alloys have attracted a wealth of attention in orthopedic fields for their superior mechanical properties, degradability, and excellent biocompatibility. Consistently, to resolve the issues on rapid degradation, more studies are dedicated to the researches on the composition design, preparation and processing, surface modification, the degradation modes of Mg alloys. Nevertheless, the mechanisms by which Mg alloys promote bone healing remain elusive. This review gives an account of specific mechanisms on Mg alloys promoting bone healing from four aspects, immunomodulatory, angiogenesis, osteogenesis and regulation of osteoclast function. We highlight the regulation of Mg alloys on the functional status and interactions of numerous cells that are involved in bone healing, including immune cells, osteogenic-related cells, osteoclasts, endothelial cells (ECs), nerve cells, etc., and summarize the signaling pathways involved, with the aim to provide the basis and support on future investigation on mechanisms on Mg alloys driving bone regeneration. More importantly, it provides a rationale and a general new basis for the application of Mg alloys in orthopedic fields. |
| first_indexed | 2024-04-11T00:54:54Z |
| format | Article |
| id | doaj.art-e2f40a5e37874c0e922995022a52e45f |
| institution | Directory Open Access Journal |
| issn | 2213-9567 |
| language | English |
| last_indexed | 2024-04-24T08:28:32Z |
| publishDate | 2022-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Journal of Magnesium and Alloys |
| spelling | doaj.art-e2f40a5e37874c0e922995022a52e45f2024-04-16T21:07:21ZengKeAi Communications Co., Ltd.Journal of Magnesium and Alloys2213-95672022-12-01101233273353Magnesium alloys for orthopedic applications:A review on the mechanisms driving bone healingNing Wang0Shude Yang1Huixin Shi2Yiping Song3Hui Sun4Qiang Wang5Lili Tan6Shu Guo7Department of Plastic Surgery, The First Hospital of China Medical University, No. 115 Nanjing North Street, Shenyang 110001, ChinaDepartment of Plastic Surgery, The First Hospital of China Medical University, No. 115 Nanjing North Street, Shenyang 110001, China; Liaoning Provincial Key Laboratory of Oral Diseases, School and Hospital of Stomatology, China Medical University, No. 117 Nanjing North Street, Shenyang 110001, ChinaDepartment of Plastic Surgery, The First Hospital of China Medical University, No. 115 Nanjing North Street, Shenyang 110001, ChinaDepartment of Plastic Surgery, The First Hospital of China Medical University, No. 115 Nanjing North Street, Shenyang 110001, ChinaLiaoning Provincial Key Laboratory of Oral Diseases, School and Hospital of Stomatology, China Medical University, No. 117 Nanjing North Street, Shenyang 110001, ChinaLiaoning Provincial Key Laboratory of Oral Diseases, School and Hospital of Stomatology, China Medical University, No. 117 Nanjing North Street, Shenyang 110001, China; Corresponding authors.Shi-Changxu Innovation Center for Advanced Materials, Institute of Metal Research, Chinese Academy of Sciences, No. 72 Wenhua Road, Shenyang, Liaoning 110016, China; Corresponding authors.Department of Plastic Surgery, The First Hospital of China Medical University, No. 115 Nanjing North Street, Shenyang 110001, China; Corresponding authors.Magnesium (Mg) alloys have attracted a wealth of attention in orthopedic fields for their superior mechanical properties, degradability, and excellent biocompatibility. Consistently, to resolve the issues on rapid degradation, more studies are dedicated to the researches on the composition design, preparation and processing, surface modification, the degradation modes of Mg alloys. Nevertheless, the mechanisms by which Mg alloys promote bone healing remain elusive. This review gives an account of specific mechanisms on Mg alloys promoting bone healing from four aspects, immunomodulatory, angiogenesis, osteogenesis and regulation of osteoclast function. We highlight the regulation of Mg alloys on the functional status and interactions of numerous cells that are involved in bone healing, including immune cells, osteogenic-related cells, osteoclasts, endothelial cells (ECs), nerve cells, etc., and summarize the signaling pathways involved, with the aim to provide the basis and support on future investigation on mechanisms on Mg alloys driving bone regeneration. More importantly, it provides a rationale and a general new basis for the application of Mg alloys in orthopedic fields.http://www.sciencedirect.com/science/article/pii/S2213956722003012Magnesium alloysBone regenerationImmunomodulationAngiogenesisOsteogenesis |
| spellingShingle | Ning Wang Shude Yang Huixin Shi Yiping Song Hui Sun Qiang Wang Lili Tan Shu Guo Magnesium alloys for orthopedic applications:A review on the mechanisms driving bone healing Journal of Magnesium and Alloys Magnesium alloys Bone regeneration Immunomodulation Angiogenesis Osteogenesis |
| title | Magnesium alloys for orthopedic applications:A review on the mechanisms driving bone healing |
| title_full | Magnesium alloys for orthopedic applications:A review on the mechanisms driving bone healing |
| title_fullStr | Magnesium alloys for orthopedic applications:A review on the mechanisms driving bone healing |
| title_full_unstemmed | Magnesium alloys for orthopedic applications:A review on the mechanisms driving bone healing |
| title_short | Magnesium alloys for orthopedic applications:A review on the mechanisms driving bone healing |
| title_sort | magnesium alloys for orthopedic applications a review on the mechanisms driving bone healing |
| topic | Magnesium alloys Bone regeneration Immunomodulation Angiogenesis Osteogenesis |
| url | http://www.sciencedirect.com/science/article/pii/S2213956722003012 |
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