Сurrent state of clinical significance of early kidney injury markers
Study objective was to reflect the current state of the early kidney damage markers clinical significance in patients with urolithiasis. Authors performed a literature review of articles (original studies and reviews) published between 2018 and February 2022 on the study of pro‑inflammatory, profibr...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
QUASAR, LLC
2022-06-01
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| Series: | Issledovaniâ i Praktika v Medicine |
| Subjects: | |
| Online Access: | https://www.rpmj.ru/rpmj/article/view/812 |
| _version_ | 1797874101050671104 |
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| author | D. N. Khotko A. I. Khotko A. I. Tarasenko A. O. Efimova |
| author_facet | D. N. Khotko A. I. Khotko A. I. Tarasenko A. O. Efimova |
| author_sort | D. N. Khotko |
| collection | DOAJ |
| description | Study objective was to reflect the current state of the early kidney damage markers clinical significance in patients with urolithiasis. Authors performed a literature review of articles (original studies and reviews) published between 2018 and February 2022 on the study of pro‑inflammatory, profibrotic and angiogenic factors in urolithiasis. Bibliographic, informational and semantic source search methods in Google Scholar, PubMed, Scopus and Embase databases were used. Analysis of a legalistic and systematic sources was carried out.Proteinuria, serum creatinine and glomerular filtration rate are now accepted as the main diagnostic markers of renal lesions. These markers already allow to reveal lesions at the stage of chronic kidney disease, when the lesion process is practically irreversible. Today it is most relevant to conduct the search for biomarkers of acute and chronic renal lesions at patients with urolithiasis to detect pathological changes in the kidneys and to determine their nature at an early stage of diagnosis.Improved diagnostic techniques destined to provide a detailed picture of the development of the pathological process in patients with urolithiasis will make it possible to prevent renal failure development at an early stage in this category of patients. |
| first_indexed | 2024-04-10T01:25:30Z |
| format | Article |
| id | doaj.art-e2f4e79ace7f4d26ba37bacef9a9cb5f |
| institution | Directory Open Access Journal |
| issn | 2410-1893 |
| language | Russian |
| last_indexed | 2024-04-10T01:25:30Z |
| publishDate | 2022-06-01 |
| publisher | QUASAR, LLC |
| record_format | Article |
| series | Issledovaniâ i Praktika v Medicine |
| spelling | doaj.art-e2f4e79ace7f4d26ba37bacef9a9cb5f2023-03-13T09:35:02ZrusQUASAR, LLCIssledovaniâ i Praktika v Medicine2410-18932022-06-019213314210.17709/2410-1893-2022-9-2-12451Сurrent state of clinical significance of early kidney injury markersD. N. Khotko0A. I. Khotko1A. I. Tarasenko2A. O. Efimova3Саратовский ГМУ им. В. И. РазумовскогоСаратовский ГМУ им. В. И. РазумовскогоПервый МГМУ им. И. М. Сеченова Минздрава России (Сеченовский Университет)Центральный клинический госпиталь ФТС РоссииStudy objective was to reflect the current state of the early kidney damage markers clinical significance in patients with urolithiasis. Authors performed a literature review of articles (original studies and reviews) published between 2018 and February 2022 on the study of pro‑inflammatory, profibrotic and angiogenic factors in urolithiasis. Bibliographic, informational and semantic source search methods in Google Scholar, PubMed, Scopus and Embase databases were used. Analysis of a legalistic and systematic sources was carried out.Proteinuria, serum creatinine and glomerular filtration rate are now accepted as the main diagnostic markers of renal lesions. These markers already allow to reveal lesions at the stage of chronic kidney disease, when the lesion process is practically irreversible. Today it is most relevant to conduct the search for biomarkers of acute and chronic renal lesions at patients with urolithiasis to detect pathological changes in the kidneys and to determine their nature at an early stage of diagnosis.Improved diagnostic techniques destined to provide a detailed picture of the development of the pathological process in patients with urolithiasis will make it possible to prevent renal failure development at an early stage in this category of patients.https://www.rpmj.ru/rpmj/article/view/812маркеры почечного повреждениямочекаменная болезньбиомаркеры почечной функции |
| spellingShingle | D. N. Khotko A. I. Khotko A. I. Tarasenko A. O. Efimova Сurrent state of clinical significance of early kidney injury markers Issledovaniâ i Praktika v Medicine маркеры почечного повреждения мочекаменная болезнь биомаркеры почечной функции |
| title | Сurrent state of clinical significance of early kidney injury markers |
| title_full | Сurrent state of clinical significance of early kidney injury markers |
| title_fullStr | Сurrent state of clinical significance of early kidney injury markers |
| title_full_unstemmed | Сurrent state of clinical significance of early kidney injury markers |
| title_short | Сurrent state of clinical significance of early kidney injury markers |
| title_sort | сurrent state of clinical significance of early kidney injury markers |
| topic | маркеры почечного повреждения мочекаменная болезнь биомаркеры почечной функции |
| url | https://www.rpmj.ru/rpmj/article/view/812 |
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