Early ribavirin for hepatitis E virus infection in patients receiving immunosuppressive therapy: a retrospective, observational study
Objective Hepatitis E virus (HEV) infections are common, self-limiting causes of acute viral hepatitis. This study aimed to analyze hepatic injury, viremia, and chronicity rates in patients with acute HEV infection receiving immunosuppressive (IS) therapy taking into account ribavirin treatment. Met...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-07-01
|
| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605231187941 |
| _version_ | 1797768168563802112 |
|---|---|
| author | Anika Franz Philipp A Reuken Sura Guliyeva Michael Rose Katharina Boden Andreas Stallmach Tony Bruns |
| author_facet | Anika Franz Philipp A Reuken Sura Guliyeva Michael Rose Katharina Boden Andreas Stallmach Tony Bruns |
| author_sort | Anika Franz |
| collection | DOAJ |
| description | Objective Hepatitis E virus (HEV) infections are common, self-limiting causes of acute viral hepatitis. This study aimed to analyze hepatic injury, viremia, and chronicity rates in patients with acute HEV infection receiving immunosuppressive (IS) therapy taking into account ribavirin treatment. Methods In this retrospective, single-center, observational study, we analyzed the disease course of 25 non-cirrhotic patients receiving IS therapy who were diagnosed with acute HEV viremia. Forty-four patients with acute HEV viremia without IS therapy were controls. Results Demographics, symptoms at presentation, and extrahepatic manifestations were not different between patients with and without IS therapy, but liver injury at presentation was less severe in patients with IS therapy. Among the patients with IS therapy, 18 (72%) received ribavirin for a median of 56 days. Sustained viral clearance was observed in 21 patients with IS therapy, whereas 3 patients relapsed after ribavirin, and 1 patient had viral persistence. Among patients with sustained viral clearance, there was a longer duration of viremia in patients with IS therapy than in those without. Conclusions In this cohort of non-cirrhotic patient with IS, early treatment with ribavirin for acute HEV infection did not improve viral clearance rates, but may have shortened the duration of viremia. |
| first_indexed | 2024-03-12T20:50:37Z |
| format | Article |
| id | doaj.art-e2f5d721751246dc882b281d7f50a0e7 |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-03-12T20:50:37Z |
| publishDate | 2023-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-e2f5d721751246dc882b281d7f50a0e72023-08-01T05:04:01ZengSAGE PublishingJournal of International Medical Research1473-23002023-07-015110.1177/03000605231187941Early ribavirin for hepatitis E virus infection in patients receiving immunosuppressive therapy: a retrospective, observational studyAnika FranzPhilipp A ReukenSura GuliyevaMichael RoseKatharina BodenAndreas StallmachTony BrunsObjective Hepatitis E virus (HEV) infections are common, self-limiting causes of acute viral hepatitis. This study aimed to analyze hepatic injury, viremia, and chronicity rates in patients with acute HEV infection receiving immunosuppressive (IS) therapy taking into account ribavirin treatment. Methods In this retrospective, single-center, observational study, we analyzed the disease course of 25 non-cirrhotic patients receiving IS therapy who were diagnosed with acute HEV viremia. Forty-four patients with acute HEV viremia without IS therapy were controls. Results Demographics, symptoms at presentation, and extrahepatic manifestations were not different between patients with and without IS therapy, but liver injury at presentation was less severe in patients with IS therapy. Among the patients with IS therapy, 18 (72%) received ribavirin for a median of 56 days. Sustained viral clearance was observed in 21 patients with IS therapy, whereas 3 patients relapsed after ribavirin, and 1 patient had viral persistence. Among patients with sustained viral clearance, there was a longer duration of viremia in patients with IS therapy than in those without. Conclusions In this cohort of non-cirrhotic patient with IS, early treatment with ribavirin for acute HEV infection did not improve viral clearance rates, but may have shortened the duration of viremia.https://doi.org/10.1177/03000605231187941 |
| spellingShingle | Anika Franz Philipp A Reuken Sura Guliyeva Michael Rose Katharina Boden Andreas Stallmach Tony Bruns Early ribavirin for hepatitis E virus infection in patients receiving immunosuppressive therapy: a retrospective, observational study Journal of International Medical Research |
| title | Early ribavirin for hepatitis E virus infection in patients receiving immunosuppressive therapy: a retrospective, observational study |
| title_full | Early ribavirin for hepatitis E virus infection in patients receiving immunosuppressive therapy: a retrospective, observational study |
| title_fullStr | Early ribavirin for hepatitis E virus infection in patients receiving immunosuppressive therapy: a retrospective, observational study |
| title_full_unstemmed | Early ribavirin for hepatitis E virus infection in patients receiving immunosuppressive therapy: a retrospective, observational study |
| title_short | Early ribavirin for hepatitis E virus infection in patients receiving immunosuppressive therapy: a retrospective, observational study |
| title_sort | early ribavirin for hepatitis e virus infection in patients receiving immunosuppressive therapy a retrospective observational study |
| url | https://doi.org/10.1177/03000605231187941 |
| work_keys_str_mv | AT anikafranz earlyribavirinforhepatitisevirusinfectioninpatientsreceivingimmunosuppressivetherapyaretrospectiveobservationalstudy AT philippareuken earlyribavirinforhepatitisevirusinfectioninpatientsreceivingimmunosuppressivetherapyaretrospectiveobservationalstudy AT suraguliyeva earlyribavirinforhepatitisevirusinfectioninpatientsreceivingimmunosuppressivetherapyaretrospectiveobservationalstudy AT michaelrose earlyribavirinforhepatitisevirusinfectioninpatientsreceivingimmunosuppressivetherapyaretrospectiveobservationalstudy AT katharinaboden earlyribavirinforhepatitisevirusinfectioninpatientsreceivingimmunosuppressivetherapyaretrospectiveobservationalstudy AT andreasstallmach earlyribavirinforhepatitisevirusinfectioninpatientsreceivingimmunosuppressivetherapyaretrospectiveobservationalstudy AT tonybruns earlyribavirinforhepatitisevirusinfectioninpatientsreceivingimmunosuppressivetherapyaretrospectiveobservationalstudy |