Development of a new quantification method using partial volume effect correction for individual energy peaks in 111In-pentetreotide SPECT/CT
Objective(s): Somatostatin receptor scintigraphy (SRS) using 111In-pentetreotide has no established quantification method. The purpose of this study was to develop a new quantitative method to correct the partial volume effect (PVE) for individual energy peaks in 111In-pentetreotide single-photon em...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2022-06-01
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| Series: | Asia Oceania Journal of Nuclear Medicine and Biology |
| Subjects: | |
| Online Access: | https://aojnmb.mums.ac.ir/article_19729_00237c23caf74f8ed7ab99754bdc3579.pdf |
| _version_ | 1818214138363510784 |
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| author | Kosuke Yamashita Noriaki Miyaji Kazuki Motegi Takashi Terauchi Shigeki Ito |
| author_facet | Kosuke Yamashita Noriaki Miyaji Kazuki Motegi Takashi Terauchi Shigeki Ito |
| author_sort | Kosuke Yamashita |
| collection | DOAJ |
| description | Objective(s): Somatostatin receptor scintigraphy (SRS) using 111In-pentetreotide has no established quantification method. The purpose of this study was to develop a new quantitative method to correct the partial volume effect (PVE) for individual energy peaks in 111In-pentetreotide single-photon emission computed tomography (SPECT).Methods: Phantom experiments were performed to construct a new quantitative method. In the phantom experiments, a NEMA IEC body phantom was used. Acquisition was performed using two energy peaks (171 keV and 245 keV) on the SPECT/CT system. The volume of interest was set at each hot sphere and lung insert in the SPECT images of each energy peak, and the recovery coefficient (RC) was calculated to understand the PVE. A new quantitative index, the indium uptake index (IUI), was calculated using the RC to correct the PVE. The quantitative accuracy of the IUI in the hot sphere was confirmed. Case studies were performed to clarify the quantitative accuracy. In a case study, the relationship between the IUI and the Krenning score, which is used as a visual assessment, was evaluated for each lesion.Results: The obtained RCs showed that the energy peak at 171 keV was faster in recovering the effect of PVE than that at 245 keV. The IUI in the 17-mm-diameter hot sphere was overestimated by 4.8% and 8.3% at 171 keV and 245 keV, respectively, compared to the actual IUIs. The relationship between IUI and Krenning score was rs=0.773 (p<0.005) at sum, rs=0.739 (p<0.005) at 171 keV, and rs=0.773 (p<0.005) at 245 keV.Conclusion: We have developed a new quantification method for 111In-pentetreotide SPECT/CT using RC-based PVE correction for an individual energy peak of 171 keV. The quantitative accuracy of this method was high even for accumulations of less than 20 mm, and it showed a good relationship with the Krenning score; therefore, the clinical usefulness of IUI was demonstrated. |
| first_indexed | 2024-12-12T06:15:25Z |
| format | Article |
| id | doaj.art-e2f6ff4bf36645b2b02e272277c3b152 |
| institution | Directory Open Access Journal |
| issn | 2322-5718 2322-5726 |
| language | English |
| last_indexed | 2024-12-12T06:15:25Z |
| publishDate | 2022-06-01 |
| publisher | Mashhad University of Medical Sciences |
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| series | Asia Oceania Journal of Nuclear Medicine and Biology |
| spelling | doaj.art-e2f6ff4bf36645b2b02e272277c3b1522022-12-22T00:35:02ZengMashhad University of Medical SciencesAsia Oceania Journal of Nuclear Medicine and Biology2322-57182322-57262022-06-0110212613710.22038/aojnmb.2022.61394.143019729Development of a new quantification method using partial volume effect correction for individual energy peaks in 111In-pentetreotide SPECT/CTKosuke Yamashita0Noriaki Miyaji1Kazuki Motegi2Takashi Terauchi3Shigeki Ito4Department of Nuclear Medicine, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, JapanDepartment of Nuclear Medicine, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, JapanDepartment of Nuclear Medicine, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, JapanDepartment of Nuclear Medicine, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, JapanFaculty of Life Sciences, Kumamoto University, Kumamoto, JapanObjective(s): Somatostatin receptor scintigraphy (SRS) using 111In-pentetreotide has no established quantification method. The purpose of this study was to develop a new quantitative method to correct the partial volume effect (PVE) for individual energy peaks in 111In-pentetreotide single-photon emission computed tomography (SPECT).Methods: Phantom experiments were performed to construct a new quantitative method. In the phantom experiments, a NEMA IEC body phantom was used. Acquisition was performed using two energy peaks (171 keV and 245 keV) on the SPECT/CT system. The volume of interest was set at each hot sphere and lung insert in the SPECT images of each energy peak, and the recovery coefficient (RC) was calculated to understand the PVE. A new quantitative index, the indium uptake index (IUI), was calculated using the RC to correct the PVE. The quantitative accuracy of the IUI in the hot sphere was confirmed. Case studies were performed to clarify the quantitative accuracy. In a case study, the relationship between the IUI and the Krenning score, which is used as a visual assessment, was evaluated for each lesion.Results: The obtained RCs showed that the energy peak at 171 keV was faster in recovering the effect of PVE than that at 245 keV. The IUI in the 17-mm-diameter hot sphere was overestimated by 4.8% and 8.3% at 171 keV and 245 keV, respectively, compared to the actual IUIs. The relationship between IUI and Krenning score was rs=0.773 (p<0.005) at sum, rs=0.739 (p<0.005) at 171 keV, and rs=0.773 (p<0.005) at 245 keV.Conclusion: We have developed a new quantification method for 111In-pentetreotide SPECT/CT using RC-based PVE correction for an individual energy peak of 171 keV. The quantitative accuracy of this method was high even for accumulations of less than 20 mm, and it showed a good relationship with the Krenning score; therefore, the clinical usefulness of IUI was demonstrated.https://aojnmb.mums.ac.ir/article_19729_00237c23caf74f8ed7ab99754bdc3579.pdfsingle photon emission computed tomography (spect)111in-pentetreotidesomatostatin receptor scintigraphy (srs)indium uptake index (iui) partial volume effect (pve) |
| spellingShingle | Kosuke Yamashita Noriaki Miyaji Kazuki Motegi Takashi Terauchi Shigeki Ito Development of a new quantification method using partial volume effect correction for individual energy peaks in 111In-pentetreotide SPECT/CT Asia Oceania Journal of Nuclear Medicine and Biology single photon emission computed tomography (spect) 111in-pentetreotide somatostatin receptor scintigraphy (srs) indium uptake index (iui) partial volume effect (pve) |
| title | Development of a new quantification method using partial volume effect correction for individual energy peaks in 111In-pentetreotide SPECT/CT |
| title_full | Development of a new quantification method using partial volume effect correction for individual energy peaks in 111In-pentetreotide SPECT/CT |
| title_fullStr | Development of a new quantification method using partial volume effect correction for individual energy peaks in 111In-pentetreotide SPECT/CT |
| title_full_unstemmed | Development of a new quantification method using partial volume effect correction for individual energy peaks in 111In-pentetreotide SPECT/CT |
| title_short | Development of a new quantification method using partial volume effect correction for individual energy peaks in 111In-pentetreotide SPECT/CT |
| title_sort | development of a new quantification method using partial volume effect correction for individual energy peaks in 111in pentetreotide spect ct |
| topic | single photon emission computed tomography (spect) 111in-pentetreotide somatostatin receptor scintigraphy (srs) indium uptake index (iui) partial volume effect (pve) |
| url | https://aojnmb.mums.ac.ir/article_19729_00237c23caf74f8ed7ab99754bdc3579.pdf |
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