Antipathogenic Compounds That Are Effective at Very Low Concentrations and Have Both Antibiofilm and Antivirulence Effects against Pseudomonas aeruginosa

Antipathogenic Compounds That Are Effective at Very Low Concentrations and Have Both Antibiofilm and Antivirulence Effects against Pseudomonas aeruginosa

ABSTRACT Pseudomonas aeruginosa, a human pathogen, causes both acute and chronic infections that are mediated by virulence factor production and biofilm formation. Since both characteristics of P. aeruginosa are regulated by quorum sensing (QS), we screened 126 synthetic chemicals for anti-QS activi...

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Bibliographic Details
Main Authors: Hyeon-Ji Hwang, Heejeong Choi, Sojeong Hong, Hyung Ryong Moon, Joon-Hee Lee
Format: Article
Language:English
Published: American Society for Microbiology 2021-10-01
Series:Microbiology Spectrum
Subjects:
Pseudomonas aeruginosa
quorum sensing
biofilm
virulence
antivirulence
antibiofilm
Online Access:https://journals.asm.org/doi/10.1128/Spectrum.00249-21

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