The Alteration of Intrinsic Excitability and Synaptic Transmission in Lumbar Spinal Motor Neurons and Interneurons of Severe Spinal Muscular Atrophy Mice

The Alteration of Intrinsic Excitability and Synaptic Transmission in Lumbar Spinal Motor Neurons and Interneurons of Severe Spinal Muscular Atrophy Mice

Spinal muscular atrophy (SMA) is the leading genetic cause of death in infants. Studies with mouse models have demonstrated increased excitability and loss of afferent proprioceptive synapses on motor neurons (MNs). To further understand functional changes in the motor neural network occurring in SM...

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Bibliografiske detaljer
Main Authors: Jianli Sun, Melissa A. Harrington
Format: Article
Sprog:English
Udgivet: Frontiers Media S.A. 2019-02-01
Serier:Frontiers in Cellular Neuroscience
Fag:
spinal muscular atrophy
intrinsic excitability
synaptic transmission
motor neuron
interneuron
Online adgang:https://www.frontiersin.org/article/10.3389/fncel.2019.00015/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00015/full

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