NAMPT and NAPRT: Two Metabolic Enzymes With Key Roles in Inflammation

NAMPT and NAPRT: Two Metabolic Enzymes With Key Roles in Inflammation

Nicotinamide phosphoribosyltransferase (NAMPT) and nicotinate phosphoribosyltransferase (NAPRT) are two intracellular enzymes that catalyze the first step in the biosynthesis of NAD from nicotinamide and nicotinic acid, respectively. By fine tuning intracellular NAD levels, they are involved in the...

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Bibliographic Details
Main Authors: Valentina Audrito, Vincenzo Gianluca Messana, Silvia Deaglio
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Oncology
Subjects:
inflammation
cancer
signaling
metabolism
DAMPs
NAMPT
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00358/full

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