Increased iron uptake by splenic hematopoietic stem cells promotes TET2-dependent erythroid regeneration

Increased iron uptake by splenic hematopoietic stem cells promotes TET2-dependent erythroid regeneration

Abstract Hematopoietic stem cells (HSCs) are capable of regenerating the blood system, but the instructive cues that direct HSCs to regenerate particular lineages lost to the injury remain elusive. Here, we show that iron is increasingly taken up by HSCs during anemia and induces erythroid gene expr...

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Bibliographic Details
Main Authors: Yu-Jung Tseng, Yuki Kageyama, Rebecca L. Murdaugh, Ayumi Kitano, Jong Hwan Kim, Kevin A. Hoegenauer, Jonathan Tiessen, Mackenzie H. Smith, Hidetaka Uryu, Koichi Takahashi, James F. Martin, Md Abul Hassan Samee, Daisuke Nakada
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-44718-0

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