Quantitative analysis of macular capillaries in diabetic patients using optical coherence tomography angiography
AIM: To quantify early changes of macular capillary parameters in type 2 diabetic patients using optical coherence tomography angiography(OCTA).METHODS: Retrospective case study. A total of 49 healthy subjects, 52 diabetic patients without retinopathy(noDR)patients, and 43 mild nonproliferative diab...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Press of International Journal of Ophthalmology (IJO PRESS)
2024-01-01
|
| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2024/1/202401003.pdf |
| _version_ | 1797376317796122624 |
|---|---|
| author | Lu Nan Yang Dongni Gu Yu Liu Jian Yang Shilin Guo Ying Shan Zhiming Liu Li Zhao Wei |
| author_facet | Lu Nan Yang Dongni Gu Yu Liu Jian Yang Shilin Guo Ying Shan Zhiming Liu Li Zhao Wei |
| author_sort | Lu Nan |
| collection | DOAJ |
| description | AIM: To quantify early changes of macular capillary parameters in type 2 diabetic patients using optical coherence tomography angiography(OCTA).METHODS: Retrospective case study. A total of 49 healthy subjects, 52 diabetic patients without retinopathy(noDR)patients, and 43 mild nonproliferative diabetic retinopathy(mNPDR)patients were recruited. Capillary perfusion density, vessel length density(VLD), and average vessel diameter(AVD)were calculated from macular OCTA images(3 mm×3 mm)of the superficial capillary plexus after segmenting large vessels and the deep capillary plexus. Parameters were compared among control subjects, noDR, and mNPDR patients. The area under the receiver operating characteristic curve estimated the abilities of these parameters to detect early changes of retinal microvascular networks.RESULTS: Significant differences were found in the VLD and AVD among the three groups(P<0.001). Compared with the control group, the noDR group had significantly higher AVD(P<0.05). VLD of both layers in patients of mNPDR group was significant decreased compared with that of noDR group(all P<0.01). Deep AVD had a higher area under the curve(AUC)of 0.796 than other parameters to discriminate the noDR group from the healthy group. Deep AVD had the highest AUC of 0.920, followed by that of the deep VLD(AUC=0.899)to discriminate the mNPDR group from the healthy group.CONCLUSIONS: NoDR patients had wider AVD than healthy individuals and longer VLD than mNPDR patients in both layers. When compared with healthy individuals, deep AVD had a stronger ability than other parameters to detect early retinal capillary impairments in noDR patients. |
| first_indexed | 2024-03-08T19:36:48Z |
| format | Article |
| id | doaj.art-e2fca9626167408894e4b6824b7bec4b |
| institution | Directory Open Access Journal |
| issn | 1672-5123 |
| language | English |
| last_indexed | 2024-03-08T19:36:48Z |
| publishDate | 2024-01-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-e2fca9626167408894e4b6824b7bec4b2023-12-26T02:07:29ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51232024-01-01241101710.3980/j.issn.1672-5123.2024.1.03202401003Quantitative analysis of macular capillaries in diabetic patients using optical coherence tomography angiographyLu Nan0Yang Dongni1Gu Yu2Liu Jian3Yang Shilin4Guo Ying5Shan Zhiming6Liu Li7Zhao Wei8Department of Ophthalmology, First Hospital of Qinhuangdao, Qinhuangdao 066000, Hebei Province, ChinaDepartment of Ophthalmology, First Hospital of Qinhuangdao, Qinhuangdao 066000, Hebei Province, ChinaDepartment of Ophthalmology, First Hospital of Qinhuangdao, Qinhuangdao 066000, Hebei Province, ChinaSchool of Control Engineering, Northeastern University at Qinhuangdao, Qinhuangdao 066004, Hebei Province, ChinaDepartment of Ophthalmology, First Hospital of Qinhuangdao, Qinhuangdao 066000, Hebei Province, ChinaDepartment of Ophthalmology, First Hospital of Qinhuangdao, Qinhuangdao 066000, Hebei Province, ChinaDepartment of Ophthalmology, First Hospital of Qinhuangdao, Qinhuangdao 066000, Hebei Province, ChinaDepartment of Ophthalmology, First Hospital of Qinhuangdao, Qinhuangdao 066000, Hebei Province, ChinaDepartment of Ophthalmology, First Hospital of Qinhuangdao, Qinhuangdao 066000, Hebei Province, ChinaAIM: To quantify early changes of macular capillary parameters in type 2 diabetic patients using optical coherence tomography angiography(OCTA).METHODS: Retrospective case study. A total of 49 healthy subjects, 52 diabetic patients without retinopathy(noDR)patients, and 43 mild nonproliferative diabetic retinopathy(mNPDR)patients were recruited. Capillary perfusion density, vessel length density(VLD), and average vessel diameter(AVD)were calculated from macular OCTA images(3 mm×3 mm)of the superficial capillary plexus after segmenting large vessels and the deep capillary plexus. Parameters were compared among control subjects, noDR, and mNPDR patients. The area under the receiver operating characteristic curve estimated the abilities of these parameters to detect early changes of retinal microvascular networks.RESULTS: Significant differences were found in the VLD and AVD among the three groups(P<0.001). Compared with the control group, the noDR group had significantly higher AVD(P<0.05). VLD of both layers in patients of mNPDR group was significant decreased compared with that of noDR group(all P<0.01). Deep AVD had a higher area under the curve(AUC)of 0.796 than other parameters to discriminate the noDR group from the healthy group. Deep AVD had the highest AUC of 0.920, followed by that of the deep VLD(AUC=0.899)to discriminate the mNPDR group from the healthy group.CONCLUSIONS: NoDR patients had wider AVD than healthy individuals and longer VLD than mNPDR patients in both layers. When compared with healthy individuals, deep AVD had a stronger ability than other parameters to detect early retinal capillary impairments in noDR patients.http://ies.ijo.cn/cn_publish/2024/1/202401003.pdfdiabetic retinopathyoptical coherence tomography angiography(octa)perfusion densityvessel length and densityvessel diameter |
| spellingShingle | Lu Nan Yang Dongni Gu Yu Liu Jian Yang Shilin Guo Ying Shan Zhiming Liu Li Zhao Wei Quantitative analysis of macular capillaries in diabetic patients using optical coherence tomography angiography Guoji Yanke Zazhi diabetic retinopathy optical coherence tomography angiography(octa) perfusion density vessel length and density vessel diameter |
| title | Quantitative analysis of macular capillaries in diabetic patients using optical coherence tomography angiography |
| title_full | Quantitative analysis of macular capillaries in diabetic patients using optical coherence tomography angiography |
| title_fullStr | Quantitative analysis of macular capillaries in diabetic patients using optical coherence tomography angiography |
| title_full_unstemmed | Quantitative analysis of macular capillaries in diabetic patients using optical coherence tomography angiography |
| title_short | Quantitative analysis of macular capillaries in diabetic patients using optical coherence tomography angiography |
| title_sort | quantitative analysis of macular capillaries in diabetic patients using optical coherence tomography angiography |
| topic | diabetic retinopathy optical coherence tomography angiography(octa) perfusion density vessel length and density vessel diameter |
| url | http://ies.ijo.cn/cn_publish/2024/1/202401003.pdf |
| work_keys_str_mv | AT lunan quantitativeanalysisofmacularcapillariesindiabeticpatientsusingopticalcoherencetomographyangiography AT yangdongni quantitativeanalysisofmacularcapillariesindiabeticpatientsusingopticalcoherencetomographyangiography AT guyu quantitativeanalysisofmacularcapillariesindiabeticpatientsusingopticalcoherencetomographyangiography AT liujian quantitativeanalysisofmacularcapillariesindiabeticpatientsusingopticalcoherencetomographyangiography AT yangshilin quantitativeanalysisofmacularcapillariesindiabeticpatientsusingopticalcoherencetomographyangiography AT guoying quantitativeanalysisofmacularcapillariesindiabeticpatientsusingopticalcoherencetomographyangiography AT shanzhiming quantitativeanalysisofmacularcapillariesindiabeticpatientsusingopticalcoherencetomographyangiography AT liuli quantitativeanalysisofmacularcapillariesindiabeticpatientsusingopticalcoherencetomographyangiography AT zhaowei quantitativeanalysisofmacularcapillariesindiabeticpatientsusingopticalcoherencetomographyangiography |