Asperlin Stimulates Energy Expenditure and Modulates Gut Microbiota in HFD-Fed Mice
Asperlin is a marine-derived, natural product with antifungal, anti-inflammatory and anti-atherosclerotic activities. In the present study, we showed that asperlin effectively prevented the development of obesity in high-fat diet (HFD)-fed mice. Oral administration of asperlin for 12 weeks significa...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-01-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/17/1/38 |
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| author | Chongming Wu Yue Zhou Guihong Qi Dong Liu Xiaoxue Cao Jiaqi Yu Rong Zhang Wenhan Lin Peng Guo |
| author_facet | Chongming Wu Yue Zhou Guihong Qi Dong Liu Xiaoxue Cao Jiaqi Yu Rong Zhang Wenhan Lin Peng Guo |
| author_sort | Chongming Wu |
| collection | DOAJ |
| description | Asperlin is a marine-derived, natural product with antifungal, anti-inflammatory and anti-atherosclerotic activities. In the present study, we showed that asperlin effectively prevented the development of obesity in high-fat diet (HFD)-fed mice. Oral administration of asperlin for 12 weeks significantly suppressed HFD-induced body weight gain and fat deposition without inhibiting food intake. Hyperlipidemia and liver steatosis were also substantially ameliorated. A respiratory metabolism monitor showed that asperlin efficiently increased energy expenditure and enhanced thermogenic gene expression in adipose tissue. Accordingly, asperlin-treated mice showed higher body temperature and were more tolerant of cold stress. Meanwhile, asperlin also increased the diversity and shifted the structure of gut microbiota. Oral administration of asperlin markedly increased the relative abundance of Bacteroidetes, leading to a higher Bacteroidetes-to-Fimicutes ratio. The HFD-induced abnormalities at both phylum and genus levels were all remarkably recovered by asperlin. These results demonstrated that asperlin is effective in preventing HFD-induced obesity and modulating gut microbiota. Its anti-obesity properties may be attributed to its effect on promoting energy expenditure. |
| first_indexed | 2024-04-14T01:40:46Z |
| format | Article |
| id | doaj.art-e2fd31fa0416448e822468fa15aca387 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-14T01:40:46Z |
| publishDate | 2019-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-e2fd31fa0416448e822468fa15aca3872022-12-22T02:19:47ZengMDPI AGMarine Drugs1660-33972019-01-011713810.3390/md17010038md17010038Asperlin Stimulates Energy Expenditure and Modulates Gut Microbiota in HFD-Fed MiceChongming Wu0Yue Zhou1Guihong Qi2Dong Liu3Xiaoxue Cao4Jiaqi Yu5Rong Zhang6Wenhan Lin7Peng Guo8Pharmacology and Toxicology Research Center, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, ChinaPharmacology and Toxicology Research Center, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, ChinaPharmacology and Toxicology Research Center, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, ChinaState Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, ChinaPharmacology and Toxicology Research Center, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, ChinaPharmacology and Toxicology Research Center, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, ChinaPharmacology and Toxicology Research Center, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, ChinaState Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, ChinaPharmacology and Toxicology Research Center, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, ChinaAsperlin is a marine-derived, natural product with antifungal, anti-inflammatory and anti-atherosclerotic activities. In the present study, we showed that asperlin effectively prevented the development of obesity in high-fat diet (HFD)-fed mice. Oral administration of asperlin for 12 weeks significantly suppressed HFD-induced body weight gain and fat deposition without inhibiting food intake. Hyperlipidemia and liver steatosis were also substantially ameliorated. A respiratory metabolism monitor showed that asperlin efficiently increased energy expenditure and enhanced thermogenic gene expression in adipose tissue. Accordingly, asperlin-treated mice showed higher body temperature and were more tolerant of cold stress. Meanwhile, asperlin also increased the diversity and shifted the structure of gut microbiota. Oral administration of asperlin markedly increased the relative abundance of Bacteroidetes, leading to a higher Bacteroidetes-to-Fimicutes ratio. The HFD-induced abnormalities at both phylum and genus levels were all remarkably recovered by asperlin. These results demonstrated that asperlin is effective in preventing HFD-induced obesity and modulating gut microbiota. Its anti-obesity properties may be attributed to its effect on promoting energy expenditure.http://www.mdpi.com/1660-3397/17/1/38asperlingut microbiotaobesitymarine drugenergy expenditure |
| spellingShingle | Chongming Wu Yue Zhou Guihong Qi Dong Liu Xiaoxue Cao Jiaqi Yu Rong Zhang Wenhan Lin Peng Guo Asperlin Stimulates Energy Expenditure and Modulates Gut Microbiota in HFD-Fed Mice Marine Drugs asperlin gut microbiota obesity marine drug energy expenditure |
| title | Asperlin Stimulates Energy Expenditure and Modulates Gut Microbiota in HFD-Fed Mice |
| title_full | Asperlin Stimulates Energy Expenditure and Modulates Gut Microbiota in HFD-Fed Mice |
| title_fullStr | Asperlin Stimulates Energy Expenditure and Modulates Gut Microbiota in HFD-Fed Mice |
| title_full_unstemmed | Asperlin Stimulates Energy Expenditure and Modulates Gut Microbiota in HFD-Fed Mice |
| title_short | Asperlin Stimulates Energy Expenditure and Modulates Gut Microbiota in HFD-Fed Mice |
| title_sort | asperlin stimulates energy expenditure and modulates gut microbiota in hfd fed mice |
| topic | asperlin gut microbiota obesity marine drug energy expenditure |
| url | http://www.mdpi.com/1660-3397/17/1/38 |
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