Association of body composition indices with insulin resistance in European adolescents: the HELENA study
Background: The different body components may contribute to the development of insulin resistance and type 2 diabetes mellitus. The aim of the present study was to examine the association of fat mass and fat free mass indices with markers of insulin resistance, independently of each other and giving...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Arán Ediciones, S. L.
|
| Series: | Nutrición Hospitalaria |
| Subjects: | |
| Online Access: | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112016000300005&lng=en&tlng=en |
| _version_ | 1828376351936086016 |
|---|---|
| author | María Sese Luis A. Moreno Laura Censi Cristina Bresidenassel Marcela González-Gross Michael Sjöström Yannis Manios Molnár Dénes Jean Dallongeville Kurt Widhalm Frederic Gottrand Steffan De-Henauw Ascensión Marcos Manuel Castillo-Garzón David Jiménez-Pavón |
| author_facet | María Sese Luis A. Moreno Laura Censi Cristina Bresidenassel Marcela González-Gross Michael Sjöström Yannis Manios Molnár Dénes Jean Dallongeville Kurt Widhalm Frederic Gottrand Steffan De-Henauw Ascensión Marcos Manuel Castillo-Garzón David Jiménez-Pavón |
| author_sort | María Sese |
| collection | DOAJ |
| description | Background: The different body components may contribute to the development of insulin resistance and type 2 diabetes mellitus. The aim of the present study was to examine the association of fat mass and fat free mass indices with markers of insulin resistance, independently of each other and giving, at the same time, gender-specific information in a wide cohort of European adolescents. Methods: A cross-sectional study in a school setting was conducted in 925 (430 males) adolescents (14.9 ± 1.2 years). Weight, height, anthropometric, bioimpedance and blood parameters were measured. Indices for fat mass and fat free mass, and homeostatic model assessment (HOMA) were calculated. Multiple regression analyses were performed adjusting for several confounders including fat free mass and fat mass when possible. Results: Indices of fat mass were positively associated with HOMA (all p < 0.01) after adjusting for all the confounders including fat free mass indices, in both sexes. Fat free mass indices were associated with HOMA, in both males and females, after adjusting for center, pubertal status, socioeconomic status and cardiorespiratory fitness, but the associations disappear when including fat mass indices in the adjustment's model. Conclusion: Fat mass indices derived from different methods are positively associated with insulin resistance independently of several confounders including fat free mass indices. In addition, the relationship of fat free mass with insulin resistance is influenced by the amount of fat mass in European adolescents. Nevertheless, future studies should focus not only on the role of fat mass, but also on other body components such as fat free mass because its role could vary depending of the level and distribution of fat mass. |
| first_indexed | 2024-04-14T07:59:53Z |
| format | Article |
| id | doaj.art-e2fea641df2f482bb5c784ba2e4b0197 |
| institution | Directory Open Access Journal |
| issn | 0212-1611 |
| language | English |
| last_indexed | 2024-04-14T07:59:53Z |
| publisher | Arán Ediciones, S. L. |
| record_format | Article |
| series | Nutrición Hospitalaria |
| spelling | doaj.art-e2fea641df2f482bb5c784ba2e4b01972022-12-22T02:04:56ZengArán Ediciones, S. L.Nutrición Hospitalaria0212-161133353353910.20960/nh.257S0212-16112016000300005Association of body composition indices with insulin resistance in European adolescents: the HELENA studyMaría Sese0Luis A. Moreno1Laura Censi2Cristina Bresidenassel3Marcela González-Gross4Michael Sjöström5Yannis Manios6Molnár Dénes7Jean Dallongeville8Kurt Widhalm9Frederic Gottrand10Steffan De-Henauw11Ascensión Marcos12Manuel Castillo-Garzón13David Jiménez-Pavón14Growth, Exercises, Nutrition and Development (GEMUD) Research GroupGrowth, Exercises, Nutrition and Development (GEMUD) Research GroupResearch Center for Food and NutritionRheinische Friedrich-wilhelms UniversitätUniversidad Politécnica de MadridKarolinska InstitutetHarokopio UniversityUniversity of PécsResearch Institute of Child Nutrition DortmundMedical University of ViennaUniversité de LilleGhent UniversityInstituto de Ciencia y Tecnología de Alimentos y NutriciónUniversidad de GranadaUniversidad de CádizBackground: The different body components may contribute to the development of insulin resistance and type 2 diabetes mellitus. The aim of the present study was to examine the association of fat mass and fat free mass indices with markers of insulin resistance, independently of each other and giving, at the same time, gender-specific information in a wide cohort of European adolescents. Methods: A cross-sectional study in a school setting was conducted in 925 (430 males) adolescents (14.9 ± 1.2 years). Weight, height, anthropometric, bioimpedance and blood parameters were measured. Indices for fat mass and fat free mass, and homeostatic model assessment (HOMA) were calculated. Multiple regression analyses were performed adjusting for several confounders including fat free mass and fat mass when possible. Results: Indices of fat mass were positively associated with HOMA (all p < 0.01) after adjusting for all the confounders including fat free mass indices, in both sexes. Fat free mass indices were associated with HOMA, in both males and females, after adjusting for center, pubertal status, socioeconomic status and cardiorespiratory fitness, but the associations disappear when including fat mass indices in the adjustment's model. Conclusion: Fat mass indices derived from different methods are positively associated with insulin resistance independently of several confounders including fat free mass indices. In addition, the relationship of fat free mass with insulin resistance is influenced by the amount of fat mass in European adolescents. Nevertheless, future studies should focus not only on the role of fat mass, but also on other body components such as fat free mass because its role could vary depending of the level and distribution of fat mass.http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112016000300005&lng=en&tlng=enResistencia a la insulinaAdolescenteGrasa corporalObesidad |
| spellingShingle | María Sese Luis A. Moreno Laura Censi Cristina Bresidenassel Marcela González-Gross Michael Sjöström Yannis Manios Molnár Dénes Jean Dallongeville Kurt Widhalm Frederic Gottrand Steffan De-Henauw Ascensión Marcos Manuel Castillo-Garzón David Jiménez-Pavón Association of body composition indices with insulin resistance in European adolescents: the HELENA study Nutrición Hospitalaria Resistencia a la insulina Adolescente Grasa corporal Obesidad |
| title | Association of body composition indices with insulin resistance in European adolescents: the HELENA study |
| title_full | Association of body composition indices with insulin resistance in European adolescents: the HELENA study |
| title_fullStr | Association of body composition indices with insulin resistance in European adolescents: the HELENA study |
| title_full_unstemmed | Association of body composition indices with insulin resistance in European adolescents: the HELENA study |
| title_short | Association of body composition indices with insulin resistance in European adolescents: the HELENA study |
| title_sort | association of body composition indices with insulin resistance in european adolescents the helena study |
| topic | Resistencia a la insulina Adolescente Grasa corporal Obesidad |
| url | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112016000300005&lng=en&tlng=en |
| work_keys_str_mv | AT mariasese associationofbodycompositionindiceswithinsulinresistanceineuropeanadolescentsthehelenastudy AT luisamoreno associationofbodycompositionindiceswithinsulinresistanceineuropeanadolescentsthehelenastudy AT lauracensi associationofbodycompositionindiceswithinsulinresistanceineuropeanadolescentsthehelenastudy AT cristinabresidenassel associationofbodycompositionindiceswithinsulinresistanceineuropeanadolescentsthehelenastudy AT marcelagonzalezgross associationofbodycompositionindiceswithinsulinresistanceineuropeanadolescentsthehelenastudy AT michaelsjostrom associationofbodycompositionindiceswithinsulinresistanceineuropeanadolescentsthehelenastudy AT yannismanios associationofbodycompositionindiceswithinsulinresistanceineuropeanadolescentsthehelenastudy AT molnardenes associationofbodycompositionindiceswithinsulinresistanceineuropeanadolescentsthehelenastudy AT jeandallongeville associationofbodycompositionindiceswithinsulinresistanceineuropeanadolescentsthehelenastudy AT kurtwidhalm associationofbodycompositionindiceswithinsulinresistanceineuropeanadolescentsthehelenastudy AT fredericgottrand associationofbodycompositionindiceswithinsulinresistanceineuropeanadolescentsthehelenastudy AT steffandehenauw associationofbodycompositionindiceswithinsulinresistanceineuropeanadolescentsthehelenastudy AT ascensionmarcos associationofbodycompositionindiceswithinsulinresistanceineuropeanadolescentsthehelenastudy AT manuelcastillogarzon associationofbodycompositionindiceswithinsulinresistanceineuropeanadolescentsthehelenastudy AT davidjimenezpavon associationofbodycompositionindiceswithinsulinresistanceineuropeanadolescentsthehelenastudy |