C2-Ceramide Induces Cell Death and Protective Autophagy in Head and Neck Squamous Cell Carcinoma Cells

C2-Ceramide Induces Cell Death and Protective Autophagy in Head and Neck Squamous Cell Carcinoma Cells

Ceramides are second messengers involved in several intracellular processes in cancer cells, amongst others. The aim of this study was to evaluate the anti-tumor efficacy of C2-ceramide (C2-Cer; N-acetyl-D-sphingosine) by investigating cell death and autophagy in head and neck squamous cell carcinom...

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Bibliographic Details
Main Authors: Wenyuan Zhu, Xinhua Wang, Yi Zhou, Huiming Wang
Format: Article
Language:English
Published: MDPI AG 2014-02-01
Series:International Journal of Molecular Sciences
Subjects:
head and neck squamous cell carcinoma
C2-ceramide
apoptosis
necroptosis
autophagy
ERK1/2 pathway
Online Access:http://www.mdpi.com/1422-0067/15/2/3336

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