TLR2 and Dectin-1 Signaling in Mouse Hematopoietic Stem and Progenitor Cells Impacts the Ability of the Antigen Presenting Cells They Produce to Activate CD4 T Cells

TLR2 and Dectin-1 Signaling in Mouse Hematopoietic Stem and Progenitor Cells Impacts the Ability of the Antigen Presenting Cells They Produce to Activate CD4 T Cells

Microbial recognition by pattern recognition receptors (PRRs) expressed on hematopoietic stem and progenitor cells (HSPCs) not only activates myelopoiesis but also programs the function of the monocytes and macrophages they produce. For instance, changes in HSPC programming modify the ability of mac...

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Bibliographic Details
Main Authors: Alba Martínez, Cristina Bono, Daniel Gozalbo, Helen S. Goodridge, M. Luisa Gil, Alberto Yáñez
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cells
Subjects:
hematopoietic stem and progenitor cells
TLR2
Dectin-1
antigen presenting cells
CD4 T cells
innate immune memory
Online Access:https://www.mdpi.com/2073-4409/9/5/1317

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