PREPARATION AND CHARACTERIZATION OF A QUERCETIN-TETRAETHYL ETHER-BASED PHOTOPROTECTIVE NANOEMULSION
Although Quercetin absorbs in the UVA/UVB electromagnetic region, it is limited for applications as a UV filter due to its low lipophilicity and capacity to penetrate the epidermis. In order to overcome this limitation, we synthetized and evaluated the photo protective properties of a derivative obt...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422019000400365&lng=en&tlng=en |
| _version_ | 1818613159592722432 |
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| author | Marlucy da Cruz Gonçalves Viviane Martins R. dos Santos Jason Guy Taylor Fernanda Barçante Perasoli Orlando David H. dos Santos Ana Carolina S. Rabelo Joamyr Victor Rossoni Junior Daniela Caldeira Costa Thiago Cazati |
| author_facet | Marlucy da Cruz Gonçalves Viviane Martins R. dos Santos Jason Guy Taylor Fernanda Barçante Perasoli Orlando David H. dos Santos Ana Carolina S. Rabelo Joamyr Victor Rossoni Junior Daniela Caldeira Costa Thiago Cazati |
| author_sort | Marlucy da Cruz Gonçalves |
| collection | DOAJ |
| description | Although Quercetin absorbs in the UVA/UVB electromagnetic region, it is limited for applications as a UV filter due to its low lipophilicity and capacity to penetrate the epidermis. In order to overcome this limitation, we synthetized and evaluated the photo protective properties of a derivative obtained from Quercetin. The derivative was prepared by alkylation of Quercetin with iodoethane and characterized by IR and NMR spectroscopy. The in vitro Solar Protection Factor was determined by the Mansur method and the cytotoxicity was evaluated using hepatocellular cell (Hep G2) cells. Finally, Quercetin and the corresponding derivative were incorporated in nanoemulsions. Nanoemulsions with particles sizes between 53 and 73 nm were obtained, and polydispersity indexes were around 0.1, indicating good homogeneity of the nanoemulsion particles. The cell viability study for the Quercetin derivative indicated a very low cytotoxicity profile. The chemical modification of Quercetin resulted in a promising compound with improved properties desirable for skin penetration and incorporation into sunscreen formulations. |
| first_indexed | 2024-12-16T15:57:41Z |
| format | Article |
| id | doaj.art-e300ffa3fe9e4c99afb70ee11e1f1eb6 |
| institution | Directory Open Access Journal |
| issn | 1678-7064 |
| language | English |
| last_indexed | 2024-12-16T15:57:41Z |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-e300ffa3fe9e4c99afb70ee11e1f1eb62022-12-21T22:25:32ZengSociedade Brasileira de QuímicaQuímica Nova1678-706442436537010.21577/0100-4042.20170345S0100-40422019000400365PREPARATION AND CHARACTERIZATION OF A QUERCETIN-TETRAETHYL ETHER-BASED PHOTOPROTECTIVE NANOEMULSIONMarlucy da Cruz GonçalvesViviane Martins R. dos SantosJason Guy TaylorFernanda Barçante PerasoliOrlando David H. dos SantosAna Carolina S. RabeloJoamyr Victor Rossoni JuniorDaniela Caldeira CostaThiago CazatiAlthough Quercetin absorbs in the UVA/UVB electromagnetic region, it is limited for applications as a UV filter due to its low lipophilicity and capacity to penetrate the epidermis. In order to overcome this limitation, we synthetized and evaluated the photo protective properties of a derivative obtained from Quercetin. The derivative was prepared by alkylation of Quercetin with iodoethane and characterized by IR and NMR spectroscopy. The in vitro Solar Protection Factor was determined by the Mansur method and the cytotoxicity was evaluated using hepatocellular cell (Hep G2) cells. Finally, Quercetin and the corresponding derivative were incorporated in nanoemulsions. Nanoemulsions with particles sizes between 53 and 73 nm were obtained, and polydispersity indexes were around 0.1, indicating good homogeneity of the nanoemulsion particles. The cell viability study for the Quercetin derivative indicated a very low cytotoxicity profile. The chemical modification of Quercetin resulted in a promising compound with improved properties desirable for skin penetration and incorporation into sunscreen formulations.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422019000400365&lng=en&tlng=ensun protection factorsunscreenphoto protectionorganic synthesisquercetin |
| spellingShingle | Marlucy da Cruz Gonçalves Viviane Martins R. dos Santos Jason Guy Taylor Fernanda Barçante Perasoli Orlando David H. dos Santos Ana Carolina S. Rabelo Joamyr Victor Rossoni Junior Daniela Caldeira Costa Thiago Cazati PREPARATION AND CHARACTERIZATION OF A QUERCETIN-TETRAETHYL ETHER-BASED PHOTOPROTECTIVE NANOEMULSION Química Nova sun protection factor sunscreen photo protection organic synthesis quercetin |
| title | PREPARATION AND CHARACTERIZATION OF A QUERCETIN-TETRAETHYL ETHER-BASED PHOTOPROTECTIVE NANOEMULSION |
| title_full | PREPARATION AND CHARACTERIZATION OF A QUERCETIN-TETRAETHYL ETHER-BASED PHOTOPROTECTIVE NANOEMULSION |
| title_fullStr | PREPARATION AND CHARACTERIZATION OF A QUERCETIN-TETRAETHYL ETHER-BASED PHOTOPROTECTIVE NANOEMULSION |
| title_full_unstemmed | PREPARATION AND CHARACTERIZATION OF A QUERCETIN-TETRAETHYL ETHER-BASED PHOTOPROTECTIVE NANOEMULSION |
| title_short | PREPARATION AND CHARACTERIZATION OF A QUERCETIN-TETRAETHYL ETHER-BASED PHOTOPROTECTIVE NANOEMULSION |
| title_sort | preparation and characterization of a quercetin tetraethyl ether based photoprotective nanoemulsion |
| topic | sun protection factor sunscreen photo protection organic synthesis quercetin |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422019000400365&lng=en&tlng=en |
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