Mitochondrial Toxicity of Drugs
Mitochondria are important targets of drug toxicity. A variety of drugs has been shown to affect the electron transport chain, coupling of oxidative phosphorylation, ?-oxidation or other mitochondrial functions. Such damaging events may lead to the opening of a large pore across the mitoch...
| Main Authors: | , , |
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| Format: | Article |
| Language: | deu |
| Published: |
Swiss Chemical Society
2006-02-01
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| Series: | CHIMIA |
| Subjects: | |
| Online Access: | https://chimia.ch/chimia/article/view/4116 |
| _version_ | 1811214430605672448 |
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| author | Liliane Todesco Katri Waldhauser Stephan Krähenbühl |
| author_facet | Liliane Todesco Katri Waldhauser Stephan Krähenbühl |
| author_sort | Liliane Todesco |
| collection | DOAJ |
| description |
Mitochondria are important targets of drug toxicity. A variety of drugs has been shown to affect the electron transport chain, coupling of oxidative phosphorylation, ?-oxidation or other mitochondrial functions. Such damaging events may lead to the opening of a large pore across
the mitochondrial membranes – the membrane permeability transition pore – eventually leading to apoptosis or necrosis of cells, depending on the cellular ATP content. Such drugs may therefore lead to organ damage, particularly in the liver, kidney, heart or skeletal muscle.
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| first_indexed | 2024-04-12T06:03:17Z |
| format | Article |
| id | doaj.art-e302fb35388a4d2b9ef862293c7d3943 |
| institution | Directory Open Access Journal |
| issn | 0009-4293 2673-2424 |
| language | deu |
| last_indexed | 2024-04-12T06:03:17Z |
| publishDate | 2006-02-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj.art-e302fb35388a4d2b9ef862293c7d39432022-12-22T03:44:58ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24242006-02-01601-210.2533/000942906777675083Mitochondrial Toxicity of DrugsLiliane TodescoKatri WaldhauserStephan Krähenbühl Mitochondria are important targets of drug toxicity. A variety of drugs has been shown to affect the electron transport chain, coupling of oxidative phosphorylation, ?-oxidation or other mitochondrial functions. Such damaging events may lead to the opening of a large pore across the mitochondrial membranes – the membrane permeability transition pore – eventually leading to apoptosis or necrosis of cells, depending on the cellular ATP content. Such drugs may therefore lead to organ damage, particularly in the liver, kidney, heart or skeletal muscle. https://chimia.ch/chimia/article/view/4116ApoptosisDrug toxicityMitochondriaNecrosisBeta-oxidationRespiratory chain |
| spellingShingle | Liliane Todesco Katri Waldhauser Stephan Krähenbühl Mitochondrial Toxicity of Drugs CHIMIA Apoptosis Drug toxicity Mitochondria Necrosis Beta-oxidation Respiratory chain |
| title | Mitochondrial Toxicity of Drugs |
| title_full | Mitochondrial Toxicity of Drugs |
| title_fullStr | Mitochondrial Toxicity of Drugs |
| title_full_unstemmed | Mitochondrial Toxicity of Drugs |
| title_short | Mitochondrial Toxicity of Drugs |
| title_sort | mitochondrial toxicity of drugs |
| topic | Apoptosis Drug toxicity Mitochondria Necrosis Beta-oxidation Respiratory chain |
| url | https://chimia.ch/chimia/article/view/4116 |
| work_keys_str_mv | AT lilianetodesco mitochondrialtoxicityofdrugs AT katriwaldhauser mitochondrialtoxicityofdrugs AT stephankrahenbuhl mitochondrialtoxicityofdrugs |