Reshaping Our Knowledge: Advancements in Understanding the Immune Response to Human Respiratory Syncytial Virus
Human respiratory syncytial virus (hRSV) is a significant cause of respiratory tract infections, particularly in young children and older adults. In this review, we aimed to comprehensively summarize what is known about the immune response to hRSV infection. We described the innate and adaptive immu...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Pathogens |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-0817/12/9/1118 |
| _version_ | 1797578129069309952 |
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| author | Federica Attaianese Sara Guiducci Sandra Trapani Federica Barbati Lorenzo Lodi Giuseppe Indolfi Chiara Azzari Silvia Ricci |
| author_facet | Federica Attaianese Sara Guiducci Sandra Trapani Federica Barbati Lorenzo Lodi Giuseppe Indolfi Chiara Azzari Silvia Ricci |
| author_sort | Federica Attaianese |
| collection | DOAJ |
| description | Human respiratory syncytial virus (hRSV) is a significant cause of respiratory tract infections, particularly in young children and older adults. In this review, we aimed to comprehensively summarize what is known about the immune response to hRSV infection. We described the innate and adaptive immune components involved, including the recognition of RSV, the inflammatory response, the role of natural killer (NK) cells, antigen presentation, T cell response, and antibody production. Understanding the complex immune response to hRSV infection is crucial for developing effective interventions against this significant respiratory pathogen. Further investigations into the immune memory generated by hRSV infection and the development of strategies to enhance immune responses may hold promise for the prevention and management of hRSV-associated diseases. |
| first_indexed | 2024-03-10T22:18:49Z |
| format | Article |
| id | doaj.art-e303276dd5c44a659c1fd4cba2f74c08 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T22:18:49Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-e303276dd5c44a659c1fd4cba2f74c082023-11-19T12:22:18ZengMDPI AGPathogens2076-08172023-09-01129111810.3390/pathogens12091118Reshaping Our Knowledge: Advancements in Understanding the Immune Response to Human Respiratory Syncytial VirusFederica Attaianese0Sara Guiducci1Sandra Trapani2Federica Barbati3Lorenzo Lodi4Giuseppe Indolfi5Chiara Azzari6Silvia Ricci7Postgraduate School of Pediatrics, University of Florence, Meyer Children’s Hospital IRCCS, 50139 Florence, ItalyPostgraduate School of Immunology, University of Florence, Meyer Children’s Hospital IRCCS, 50139 Florence, ItalyPediatric Unit, Meyer Children’s Hospital IRCCS, Viale Pieraccini 24, 50139 Florence, ItalyPostgraduate School of Pediatrics, University of Florence, Meyer Children’s Hospital IRCCS, 50139 Florence, ItalyDepartment of Health Sciences, University of Florence, 50139 Florence, ItalyPediatric Unit, Meyer Children’s Hospital IRCCS, Viale Pieraccini 24, 50139 Florence, ItalyDepartment of Health Sciences, University of Florence, 50139 Florence, ItalyDepartment of Health Sciences, University of Florence, 50139 Florence, ItalyHuman respiratory syncytial virus (hRSV) is a significant cause of respiratory tract infections, particularly in young children and older adults. In this review, we aimed to comprehensively summarize what is known about the immune response to hRSV infection. We described the innate and adaptive immune components involved, including the recognition of RSV, the inflammatory response, the role of natural killer (NK) cells, antigen presentation, T cell response, and antibody production. Understanding the complex immune response to hRSV infection is crucial for developing effective interventions against this significant respiratory pathogen. Further investigations into the immune memory generated by hRSV infection and the development of strategies to enhance immune responses may hold promise for the prevention and management of hRSV-associated diseases.https://www.mdpi.com/2076-0817/12/9/1118immune responseRSVsyncytial respiratory virusprevention strategy |
| spellingShingle | Federica Attaianese Sara Guiducci Sandra Trapani Federica Barbati Lorenzo Lodi Giuseppe Indolfi Chiara Azzari Silvia Ricci Reshaping Our Knowledge: Advancements in Understanding the Immune Response to Human Respiratory Syncytial Virus Pathogens immune response RSV syncytial respiratory virus prevention strategy |
| title | Reshaping Our Knowledge: Advancements in Understanding the Immune Response to Human Respiratory Syncytial Virus |
| title_full | Reshaping Our Knowledge: Advancements in Understanding the Immune Response to Human Respiratory Syncytial Virus |
| title_fullStr | Reshaping Our Knowledge: Advancements in Understanding the Immune Response to Human Respiratory Syncytial Virus |
| title_full_unstemmed | Reshaping Our Knowledge: Advancements in Understanding the Immune Response to Human Respiratory Syncytial Virus |
| title_short | Reshaping Our Knowledge: Advancements in Understanding the Immune Response to Human Respiratory Syncytial Virus |
| title_sort | reshaping our knowledge advancements in understanding the immune response to human respiratory syncytial virus |
| topic | immune response RSV syncytial respiratory virus prevention strategy |
| url | https://www.mdpi.com/2076-0817/12/9/1118 |
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