Molecular Mechanisms of Glucocorticoid Resistance in Corticotropinomas: New Developments and Drug Targets
Cushing's disease is characterized by excessive adrenocorticotropin hormone (ACTH) secretion caused by a corticotroph tumor of the pituitary gland, leading to hypercortisolism and increased morbidity and mortality. The molecular causes of the disease are not completely understood, therefore mor...
Main Authors: | Denis Ciato, Adriana Albani |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-01-01
|
Series: | Frontiers in Endocrinology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2020.00021/full |
Similar Items
-
The Role of Glucocorticoid Receptor in the Pathophysiology of Pituitary Corticotroph Adenomas
by: Daniela Regazzo, et al.
Published: (2022-06-01) -
An unexpected, mild phenotype of glucocorticoid resistance associated with glucocorticoid receptor gene mutation case report and review of the literature
by: Ágnes Molnár, et al.
Published: (2018-03-01) -
Acquired Glucocorticoid Resistance Due to Homologous Glucocorticoid Receptor Downregulation: A Modern Look at an Age-Old Problem
by: Lee-Maine L. Spies, et al.
Published: (2021-09-01) -
LPS regulates the expression of glucocorticoid receptor α and β isoforms and induces a selective glucocorticoid resistance in vitro
by: Maria Luisa Molina, et al.
Published: (2017-10-01) -
Mitochondrial Glucocorticoid Receptors and Their Actions
by: Ioanna Kokkinopoulou, et al.
Published: (2021-06-01)