Case Report: Multiple colorectal cancers in a patient with Ulcerative colitis and Lynch syndrome: Is there a role for prophylactic colectomy? A short report and review of literature
It is a known fact that Lynch syndrome (LS) and Ulcerative colitis (UC) are individually associated with increased risk of colorectal cancer. While there is no conclusive evidence to demonstrate a cumulative risk when these two conditions coexist, available data suggest early onset and synchronous c...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1031606/full |
| _version_ | 1797979200447053824 |
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| author | Adewale Adeoba Ayeni Peter Waterland Matthew Evans Shika Singhal Rajan Kumar Patel Akinfemi Akingboye |
| author_facet | Adewale Adeoba Ayeni Peter Waterland Matthew Evans Shika Singhal Rajan Kumar Patel Akinfemi Akingboye |
| author_sort | Adewale Adeoba Ayeni |
| collection | DOAJ |
| description | It is a known fact that Lynch syndrome (LS) and Ulcerative colitis (UC) are individually associated with increased risk of colorectal cancer. While there is no conclusive evidence to demonstrate a cumulative risk when these two conditions coexist, available data suggest early onset and synchronous cancers are synonymous to this group. We have reported an unusual case of multiple synchronous colorectal cancers in a young man with ulcerative colitis and Lynch syndrome also known as Hereditary Nonpolyposis Colorectal Cancer (HNPCC) gene mutation. We propose that conducting a detailed genetic mutation profile in LS patients may play a key role in guiding the intensity of endoscopic surveillance and that a concerted, pragmatic, patient guided approach should be adopted on the subject of prophylactic colectomy when UC and LS co-exist. |
| first_indexed | 2024-04-11T05:35:13Z |
| format | Article |
| id | doaj.art-e3053ee437d34426ac8c179ea0d5ffd9 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T05:35:13Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-e3053ee437d34426ac8c179ea0d5ffd92022-12-22T14:12:49ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-12-011210.3389/fonc.2022.10316061031606Case Report: Multiple colorectal cancers in a patient with Ulcerative colitis and Lynch syndrome: Is there a role for prophylactic colectomy? A short report and review of literatureAdewale Adeoba Ayeni0Peter Waterland1Matthew Evans2Shika Singhal3Rajan Kumar Patel4Akinfemi Akingboye5Department of General Surgery, The Dudley Group Foundation NHS Trust, Russells Hall Hospital, Dudley, West MidlandsDepartment of General Surgery, The Dudley Group Foundation NHS Trust, Russells Hall Hospital, Dudley, West MidlandsDepartment of Pathology, New Cross Hospital, Wolverhampton, United KingdomDepartment of Pathology, New Cross Hospital, Wolverhampton, United KingdomDepartment of General Surgery, The Dudley Group Foundation NHS Trust, Russells Hall Hospital, Dudley, West MidlandsDepartment of General Surgery, The Dudley Group Foundation NHS Trust, Russells Hall Hospital, Dudley, West MidlandsIt is a known fact that Lynch syndrome (LS) and Ulcerative colitis (UC) are individually associated with increased risk of colorectal cancer. While there is no conclusive evidence to demonstrate a cumulative risk when these two conditions coexist, available data suggest early onset and synchronous cancers are synonymous to this group. We have reported an unusual case of multiple synchronous colorectal cancers in a young man with ulcerative colitis and Lynch syndrome also known as Hereditary Nonpolyposis Colorectal Cancer (HNPCC) gene mutation. We propose that conducting a detailed genetic mutation profile in LS patients may play a key role in guiding the intensity of endoscopic surveillance and that a concerted, pragmatic, patient guided approach should be adopted on the subject of prophylactic colectomy when UC and LS co-exist.https://www.frontiersin.org/articles/10.3389/fonc.2022.1031606/fullHNPCC: hereditary non-polyposis colorectal cancerIBD - inflammatory bowel diseasecolorectal cancerLynch syndromeUlcerative colitis (colitis ulcerosa) |
| spellingShingle | Adewale Adeoba Ayeni Peter Waterland Matthew Evans Shika Singhal Rajan Kumar Patel Akinfemi Akingboye Case Report: Multiple colorectal cancers in a patient with Ulcerative colitis and Lynch syndrome: Is there a role for prophylactic colectomy? A short report and review of literature Frontiers in Oncology HNPCC: hereditary non-polyposis colorectal cancer IBD - inflammatory bowel disease colorectal cancer Lynch syndrome Ulcerative colitis (colitis ulcerosa) |
| title | Case Report: Multiple colorectal cancers in a patient with Ulcerative colitis and Lynch syndrome: Is there a role for prophylactic colectomy? A short report and review of literature |
| title_full | Case Report: Multiple colorectal cancers in a patient with Ulcerative colitis and Lynch syndrome: Is there a role for prophylactic colectomy? A short report and review of literature |
| title_fullStr | Case Report: Multiple colorectal cancers in a patient with Ulcerative colitis and Lynch syndrome: Is there a role for prophylactic colectomy? A short report and review of literature |
| title_full_unstemmed | Case Report: Multiple colorectal cancers in a patient with Ulcerative colitis and Lynch syndrome: Is there a role for prophylactic colectomy? A short report and review of literature |
| title_short | Case Report: Multiple colorectal cancers in a patient with Ulcerative colitis and Lynch syndrome: Is there a role for prophylactic colectomy? A short report and review of literature |
| title_sort | case report multiple colorectal cancers in a patient with ulcerative colitis and lynch syndrome is there a role for prophylactic colectomy a short report and review of literature |
| topic | HNPCC: hereditary non-polyposis colorectal cancer IBD - inflammatory bowel disease colorectal cancer Lynch syndrome Ulcerative colitis (colitis ulcerosa) |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1031606/full |
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