Lipid Nanocarrier-Based Drug Delivery Systems: Therapeutic Advances in the Treatment of Lung Cancer
So-Jung Kim,1,* Nidhi Puranik,2,* Dhananjay Yadav,3,* Jun-O Jin,1 Peter CW Lee4 1Department of Microbiology, University of Ulsan College of Medicine, Seoul, 05505, South Korea; 2Department of Biochemistry & Genetics, Barkatullah University, Bhopal, Madhya Pradesh, 462026,...
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Dove Medical Press
2023-05-01
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Series: | International Journal of Nanomedicine |
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Online Access: | https://www.dovepress.com/lipid-nanocarrier-based-drug-delivery-systems-therapeutic-advances-in--peer-reviewed-fulltext-article-IJN |
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author | Kim SJ Puranik N Yadav D Jin JO Lee PC |
author_facet | Kim SJ Puranik N Yadav D Jin JO Lee PC |
author_sort | Kim SJ |
collection | DOAJ |
description | So-Jung Kim,1,* Nidhi Puranik,2,* Dhananjay Yadav,3,* Jun-O Jin,1 Peter CW Lee4 1Department of Microbiology, University of Ulsan College of Medicine, Seoul, 05505, South Korea; 2Department of Biochemistry & Genetics, Barkatullah University, Bhopal, Madhya Pradesh, 462026, India; 3Department of Life Science, Yeungnam University, Gyeongsan, 38541, Korea; 4Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, ASAN Medical Center, Seoul, 05505, South Korea*These authors contributed equally to this workCorrespondence: Peter CW Lee, Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, ASAN Medical Center, Seoul, 05505, Korea, Email pclee@amc.seoul.kr Jun-O Jin, Department of Microbiology, University of Ulsan College of Medicine, Seoul, 05505, Korea, Email junojin@amc.seoul.krAbstract: Although various treatments are currently being developed, lung cancer still has a very high mortality rate. Moreover, while various strategies for the diagnosis and treatment of lung cancer are being used in clinical settings, in many cases, lung cancer does not respond to treatment and presents reducing survival rates. Cancer nanotechnology, also known as nanotechnology in cancer, is a relatively new topic of study that brings together scientists from a variety of fields, including chemistry, biology, engineering, and medicine. The use of lipid-based nanocarriers to aid drug distribution has already had a significant impact in several scientific fields. Lipid-based nanocarriers have been demonstrated to help stabilize therapeutic compounds, overcome barriers to cellular and tissue absorption, and improve in vivo drug delivery to specific target areas. For this reason, lipid-based nanocarriers are being actively researched and used for lung cancer treatment and vaccine development. This review discusses the improvements in drug delivery achieved with lipid-based nanocarriers, the obstacles that still exist with in vivo applications, and the current clinical and experimental applications of lipid-based nanocarriers in lung cancer treatment and management.Keywords: lung cancer, lipid-based nanocarriers, liposome, drug delivery system |
first_indexed | 2024-03-13T10:30:26Z |
format | Article |
id | doaj.art-e3055afec819442fafe1335541857e4c |
institution | Directory Open Access Journal |
issn | 1178-2013 |
language | English |
last_indexed | 2024-03-13T10:30:26Z |
publishDate | 2023-05-01 |
publisher | Dove Medical Press |
record_format | Article |
series | International Journal of Nanomedicine |
spelling | doaj.art-e3055afec819442fafe1335541857e4c2023-05-18T18:42:34ZengDove Medical PressInternational Journal of Nanomedicine1178-20132023-05-01Volume 182659267683826Lipid Nanocarrier-Based Drug Delivery Systems: Therapeutic Advances in the Treatment of Lung CancerKim SJPuranik NYadav DJin JOLee PCSo-Jung Kim,1,* Nidhi Puranik,2,* Dhananjay Yadav,3,* Jun-O Jin,1 Peter CW Lee4 1Department of Microbiology, University of Ulsan College of Medicine, Seoul, 05505, South Korea; 2Department of Biochemistry & Genetics, Barkatullah University, Bhopal, Madhya Pradesh, 462026, India; 3Department of Life Science, Yeungnam University, Gyeongsan, 38541, Korea; 4Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, ASAN Medical Center, Seoul, 05505, South Korea*These authors contributed equally to this workCorrespondence: Peter CW Lee, Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, ASAN Medical Center, Seoul, 05505, Korea, Email pclee@amc.seoul.kr Jun-O Jin, Department of Microbiology, University of Ulsan College of Medicine, Seoul, 05505, Korea, Email junojin@amc.seoul.krAbstract: Although various treatments are currently being developed, lung cancer still has a very high mortality rate. Moreover, while various strategies for the diagnosis and treatment of lung cancer are being used in clinical settings, in many cases, lung cancer does not respond to treatment and presents reducing survival rates. Cancer nanotechnology, also known as nanotechnology in cancer, is a relatively new topic of study that brings together scientists from a variety of fields, including chemistry, biology, engineering, and medicine. The use of lipid-based nanocarriers to aid drug distribution has already had a significant impact in several scientific fields. Lipid-based nanocarriers have been demonstrated to help stabilize therapeutic compounds, overcome barriers to cellular and tissue absorption, and improve in vivo drug delivery to specific target areas. For this reason, lipid-based nanocarriers are being actively researched and used for lung cancer treatment and vaccine development. This review discusses the improvements in drug delivery achieved with lipid-based nanocarriers, the obstacles that still exist with in vivo applications, and the current clinical and experimental applications of lipid-based nanocarriers in lung cancer treatment and management.Keywords: lung cancer, lipid-based nanocarriers, liposome, drug delivery systemhttps://www.dovepress.com/lipid-nanocarrier-based-drug-delivery-systems-therapeutic-advances-in--peer-reviewed-fulltext-article-IJNlung cancerlipid-based nanocarriersliposomedrug delivery system |
spellingShingle | Kim SJ Puranik N Yadav D Jin JO Lee PC Lipid Nanocarrier-Based Drug Delivery Systems: Therapeutic Advances in the Treatment of Lung Cancer International Journal of Nanomedicine lung cancer lipid-based nanocarriers liposome drug delivery system |
title | Lipid Nanocarrier-Based Drug Delivery Systems: Therapeutic Advances in the Treatment of Lung Cancer |
title_full | Lipid Nanocarrier-Based Drug Delivery Systems: Therapeutic Advances in the Treatment of Lung Cancer |
title_fullStr | Lipid Nanocarrier-Based Drug Delivery Systems: Therapeutic Advances in the Treatment of Lung Cancer |
title_full_unstemmed | Lipid Nanocarrier-Based Drug Delivery Systems: Therapeutic Advances in the Treatment of Lung Cancer |
title_short | Lipid Nanocarrier-Based Drug Delivery Systems: Therapeutic Advances in the Treatment of Lung Cancer |
title_sort | lipid nanocarrier based drug delivery systems therapeutic advances in the treatment of lung cancer |
topic | lung cancer lipid-based nanocarriers liposome drug delivery system |
url | https://www.dovepress.com/lipid-nanocarrier-based-drug-delivery-systems-therapeutic-advances-in--peer-reviewed-fulltext-article-IJN |
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