SRF: a seriously responsible factor in cardiac development and disease
Abstract The molecular mechanisms that regulate embryogenesis and cardiac development are calibrated by multiple signal transduction pathways within or between different cell lineages via autocrine or paracrine mechanisms of action. The heart is the first functional organ to form during development,...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | Journal of Biomedical Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12929-022-00820-3 |
| _version_ | 1818253241424543744 |
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| author | Anushka Deshpande Prithviraj Manohar Vijaya Shetty Norbert Frey Ashraf Yusuf Rangrez |
| author_facet | Anushka Deshpande Prithviraj Manohar Vijaya Shetty Norbert Frey Ashraf Yusuf Rangrez |
| author_sort | Anushka Deshpande |
| collection | DOAJ |
| description | Abstract The molecular mechanisms that regulate embryogenesis and cardiac development are calibrated by multiple signal transduction pathways within or between different cell lineages via autocrine or paracrine mechanisms of action. The heart is the first functional organ to form during development, which highlights the importance of this organ in later stages of growth. Knowledge of the regulatory mechanisms underlying cardiac development and adult cardiac homeostasis paves the way for discovering therapeutic possibilities for cardiac disease treatment. Serum response factor (SRF) is a major transcription factor that controls both embryonic and adult cardiac development. SRF expression is needed through the duration of development, from the first mesodermal cell in a developing embryo to the last cell damaged by infarction in the myocardium. Precise regulation of SRF expression is critical for mesoderm formation and cardiac crescent formation in the embryo, and altered SRF levels lead to cardiomyopathies in the adult heart, suggesting the vital role played by SRF in cardiac development and disease. This review provides a detailed overview of SRF and its partners in their various functions and discusses the future scope and possible therapeutic potential of SRF in the cardiovascular system. |
| first_indexed | 2024-12-12T16:36:57Z |
| format | Article |
| id | doaj.art-e305af204157459fb192cca46cba4dd0 |
| institution | Directory Open Access Journal |
| issn | 1423-0127 |
| language | English |
| last_indexed | 2024-12-12T16:36:57Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Biomedical Science |
| spelling | doaj.art-e305af204157459fb192cca46cba4dd02022-12-22T00:18:39ZengBMCJournal of Biomedical Science1423-01272022-06-0129112110.1186/s12929-022-00820-3SRF: a seriously responsible factor in cardiac development and diseaseAnushka Deshpande0Prithviraj Manohar Vijaya Shetty1Norbert Frey2Ashraf Yusuf Rangrez3Department of Internal Medicine III, Cardiology and Angiology, University Medical Center Schleswig-HolsteinDepartment of Cardiology, Angiology and Pneumology, University Hospital HeidelbergDepartment of Cardiology, Angiology and Pneumology, University Hospital HeidelbergDepartment of Cardiology, Angiology and Pneumology, University Hospital HeidelbergAbstract The molecular mechanisms that regulate embryogenesis and cardiac development are calibrated by multiple signal transduction pathways within or between different cell lineages via autocrine or paracrine mechanisms of action. The heart is the first functional organ to form during development, which highlights the importance of this organ in later stages of growth. Knowledge of the regulatory mechanisms underlying cardiac development and adult cardiac homeostasis paves the way for discovering therapeutic possibilities for cardiac disease treatment. Serum response factor (SRF) is a major transcription factor that controls both embryonic and adult cardiac development. SRF expression is needed through the duration of development, from the first mesodermal cell in a developing embryo to the last cell damaged by infarction in the myocardium. Precise regulation of SRF expression is critical for mesoderm formation and cardiac crescent formation in the embryo, and altered SRF levels lead to cardiomyopathies in the adult heart, suggesting the vital role played by SRF in cardiac development and disease. This review provides a detailed overview of SRF and its partners in their various functions and discusses the future scope and possible therapeutic potential of SRF in the cardiovascular system.https://doi.org/10.1186/s12929-022-00820-3Serum response factorHeartSRF cofactorsSRF regulatorsEmbryonic developmentCardiogenesis |
| spellingShingle | Anushka Deshpande Prithviraj Manohar Vijaya Shetty Norbert Frey Ashraf Yusuf Rangrez SRF: a seriously responsible factor in cardiac development and disease Journal of Biomedical Science Serum response factor Heart SRF cofactors SRF regulators Embryonic development Cardiogenesis |
| title | SRF: a seriously responsible factor in cardiac development and disease |
| title_full | SRF: a seriously responsible factor in cardiac development and disease |
| title_fullStr | SRF: a seriously responsible factor in cardiac development and disease |
| title_full_unstemmed | SRF: a seriously responsible factor in cardiac development and disease |
| title_short | SRF: a seriously responsible factor in cardiac development and disease |
| title_sort | srf a seriously responsible factor in cardiac development and disease |
| topic | Serum response factor Heart SRF cofactors SRF regulators Embryonic development Cardiogenesis |
| url | https://doi.org/10.1186/s12929-022-00820-3 |
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