Generation of new human iPSC cell line (UOMi008-A) from a Hypophosphatasia patient
A new induced pluripotent stem cell (iPSC) line namely UOMi008-A was generated from a patient having a childhood onset of Hypophosphatasia (HPP). This patient has compound heterozygous mutations c.571G > A (p.Glu191Lys) and c.1001G > A (p.Gly334Asp) in the ALPL gene respectively. This iPSC lin...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506122002409 |
| _version_ | 1797985862330351616 |
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| author | Abhay Srivastava Elika Verma Cheryl Rockman-Greenberg Sanjiv Dhingra |
| author_facet | Abhay Srivastava Elika Verma Cheryl Rockman-Greenberg Sanjiv Dhingra |
| author_sort | Abhay Srivastava |
| collection | DOAJ |
| description | A new induced pluripotent stem cell (iPSC) line namely UOMi008-A was generated from a patient having a childhood onset of Hypophosphatasia (HPP). This patient has compound heterozygous mutations c.571G > A (p.Glu191Lys) and c.1001G > A (p.Gly334Asp) in the ALPL gene respectively. This iPSC line will be used for in vitro disease modeling, which will aid in delineating the underlying molecular mechanism involved in disease pathogenesis and provide plausible new therapeutic directions. |
| first_indexed | 2024-04-11T07:23:44Z |
| format | Article |
| id | doaj.art-e3072e9736fe4bc08a39b2d5be9d92b5 |
| institution | Directory Open Access Journal |
| issn | 1873-5061 |
| language | English |
| last_indexed | 2024-04-11T07:23:44Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj.art-e3072e9736fe4bc08a39b2d5be9d92b52022-12-22T04:37:07ZengElsevierStem Cell Research1873-50612022-10-0164102891Generation of new human iPSC cell line (UOMi008-A) from a Hypophosphatasia patientAbhay Srivastava0Elika Verma1Cheryl Rockman-Greenberg2Sanjiv Dhingra3Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Regenerative Medicine Program, Department of Physiology and Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, CanadaInstitute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Regenerative Medicine Program, Department of Physiology and Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, CanadaDepartment of Pediatrics and Child Health, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, CanadaInstitute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Regenerative Medicine Program, Department of Physiology and Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Canada; Corresponding author.A new induced pluripotent stem cell (iPSC) line namely UOMi008-A was generated from a patient having a childhood onset of Hypophosphatasia (HPP). This patient has compound heterozygous mutations c.571G > A (p.Glu191Lys) and c.1001G > A (p.Gly334Asp) in the ALPL gene respectively. This iPSC line will be used for in vitro disease modeling, which will aid in delineating the underlying molecular mechanism involved in disease pathogenesis and provide plausible new therapeutic directions.http://www.sciencedirect.com/science/article/pii/S1873506122002409 |
| spellingShingle | Abhay Srivastava Elika Verma Cheryl Rockman-Greenberg Sanjiv Dhingra Generation of new human iPSC cell line (UOMi008-A) from a Hypophosphatasia patient Stem Cell Research |
| title | Generation of new human iPSC cell line (UOMi008-A) from a Hypophosphatasia patient |
| title_full | Generation of new human iPSC cell line (UOMi008-A) from a Hypophosphatasia patient |
| title_fullStr | Generation of new human iPSC cell line (UOMi008-A) from a Hypophosphatasia patient |
| title_full_unstemmed | Generation of new human iPSC cell line (UOMi008-A) from a Hypophosphatasia patient |
| title_short | Generation of new human iPSC cell line (UOMi008-A) from a Hypophosphatasia patient |
| title_sort | generation of new human ipsc cell line uomi008 a from a hypophosphatasia patient |
| url | http://www.sciencedirect.com/science/article/pii/S1873506122002409 |
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