Dedifferentiated Liposarcoma of the Gastroesophageal Junction
Liposarcoma is one of the most common sarcomas in adults, but very rarely presents as a primary in the upper gastrointestinal system. Herein, we present a 71-year-old male patient who underwent wedge excision biopsy twice and then fine needle aspiration and total gastrectomy for a recurrent gastroeo...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Federation of Turkish Pathology Societies
2018-01-01
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| Series: | Türk Patoloji Dergisi |
| Subjects: | |
| Online Access: | http://www.turkjpath.org/pdf.php3?id=1735 |
| Summary: | Liposarcoma is one of the most common sarcomas in adults, but very rarely presents as a primary in the upper gastrointestinal system. Herein, we present a 71-year-old male patient who underwent wedge excision biopsy twice and then fine needle aspiration and total gastrectomy for a recurrent gastroeosophageal junction mass. In microscopic sections, both well-differentiated and dedifferentiated components were seen. Tumor cells were positive for MDM2, CDK4 and negative for CD117, DOG1, CD34, SMA, Desmin, S-100, HMB45, SOX10, AE1/AE3, CAM5.2, CK18. Fluorescence in situ hybridization (FISH) was performed and MDM2 gene (12q15) amplification was detected. According to these findings, a diagnosis of dedifferentiated liposarcoma was supported. We believe this is the first reported case of dedifferentiated liposarcoma of the gastroesophageal junction. |
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| ISSN: | 1018-5615 1309-5730 |