Association of Influenza Vaccination and Prognosis in Patients Testing Positive to SARS-CoV-2 Swab Test: A Large-Scale Italian Multi-Database Cohort Study
To investigate the association of the 2019–2020 influenza vaccine with prognosis of patients positive for SARS-CoV-2A, a large multi-database cohort study was conducted in four Italian regions (i.e., Lazio, Lombardy, Veneto, and Tuscany) and the Reggio Emilia province (Emilia-Romagna). More than 21...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-07-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/9/7/716 |
| _version_ | 1797526014012686336 |
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| author | Marco Massari Stefania Spila-Alegiani Massimo Fabiani Valeria Belleudi Gianluca Trifirò Ursula Kirchmayer Francesca Romana Poggi Pamela Mancuso Francesca Menniti-Ippolito Rosa Gini Claudia Bartolini Olivia Leoni Michele Ercolanoni Filippo Da-Re Stefano Guzzinati Nicoletta Luxi Flavia Riccardo Paolo Giorgi-Rossi |
| author_facet | Marco Massari Stefania Spila-Alegiani Massimo Fabiani Valeria Belleudi Gianluca Trifirò Ursula Kirchmayer Francesca Romana Poggi Pamela Mancuso Francesca Menniti-Ippolito Rosa Gini Claudia Bartolini Olivia Leoni Michele Ercolanoni Filippo Da-Re Stefano Guzzinati Nicoletta Luxi Flavia Riccardo Paolo Giorgi-Rossi |
| author_sort | Marco Massari |
| collection | DOAJ |
| description | To investigate the association of the 2019–2020 influenza vaccine with prognosis of patients positive for SARS-CoV-2A, a large multi-database cohort study was conducted in four Italian regions (i.e., Lazio, Lombardy, Veneto, and Tuscany) and the Reggio Emilia province (Emilia-Romagna). More than 21 million adults were residing in the study area (42% of the population). We included 115,945 COVID-19 cases diagnosed during the first wave of the pandemic (February–May, 2020); 34.6% of these had been vaccinated against influenza. Three outcomes were considered: hospitalization, death, and intensive care unit (ICU) admission/death. The adjusted relative risk (RR) of being hospitalized in the vaccinated group when compared with the non-vaccinated group was 0.87 (95% CI: 0.86–0.88). This reduction in risk was not confirmed for death (RR = 1.04; 95% CI: 1.01–1.06), or for the combined outcome of ICU admission or death. In conclusion, our study, conducted on the vast majority of the population during the first wave of the pandemic in Italy, showed a 13% statistically significant reduction in the risk of hospitalization in some geographical areas and in the younger population. No impact of seasonal influenza vaccination on COVID-19 prognosis in terms of death and death or ICU admission was estimated. |
| first_indexed | 2024-03-10T09:21:12Z |
| format | Article |
| id | doaj.art-e307625db8424a638f922e180086519a |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T09:21:12Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-e307625db8424a638f922e180086519a2023-11-22T05:11:55ZengMDPI AGVaccines2076-393X2021-07-019771610.3390/vaccines9070716Association of Influenza Vaccination and Prognosis in Patients Testing Positive to SARS-CoV-2 Swab Test: A Large-Scale Italian Multi-Database Cohort StudyMarco Massari0Stefania Spila-Alegiani1Massimo Fabiani2Valeria Belleudi3Gianluca Trifirò4Ursula Kirchmayer5Francesca Romana Poggi6Pamela Mancuso7Francesca Menniti-Ippolito8Rosa Gini9Claudia Bartolini10Olivia Leoni11Michele Ercolanoni12Filippo Da-Re13Stefano Guzzinati14Nicoletta Luxi15Flavia Riccardo16Paolo Giorgi-Rossi17Pharmacoepidemiology Unit, National Centre for Drug Research and Evaluation (CNRVF), Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, ItalyPharmacoepidemiology Unit, National Centre for Drug Research and Evaluation (CNRVF), Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, ItalyDepartment of Infectious Diseases (DMI), Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, ItalyDepartment of Epidemiology ASL Roma 1, Lazio Regional Health Service, Via Cristoforo Colombo 112, 00147 Rome, ItalyDepartment of Diagnostics and Public Health, University of Verona, Piazzale L.A. Scuro 3, 37134 Verona, ItalyDepartment of Epidemiology ASL Roma 1, Lazio Regional Health Service, Via Cristoforo Colombo 112, 00147 Rome, ItalyDepartment of Epidemiology ASL Roma 1, Lazio Regional Health Service, Via Cristoforo Colombo 112, 00147 Rome, ItalyEpidemiology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Via Giovanni Amendola 2, 42122 Reggio Emilia, ItalyPharmacoepidemiology Unit, National Centre for Drug Research and Evaluation (CNRVF), Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, ItalyAgenzia Regionale di Sanità della Toscana, Via Pietro Dazzi 1, 50141 Florence, ItalyAgenzia Regionale di Sanità della Toscana, Via Pietro Dazzi 1, 50141 Florence, ItalyDepartment of Health of Lombardy Region, Epidemiology Observatory, Piazza Città di Lombardia 1, 20124 Milan, ItalyDepartment of Health of Lombardy Region, Epidemiology Observatory, Piazza Città di Lombardia 1, 20124 Milan, ItalyRegional Directorate of Prevention, Food Safety, Veterinary Public Health, Regione del Veneto, Rio Novo-Dorsoduro 3493, 30123 Venice, ItalyAzienda Zero, Regione del Veneto, Passaggio Luigi Gaudenzio, 1, 35131 Padova, ItalyDepartment BIOMORF, University of Messina, Piazza Pugliatti 1, 98122 Messina, ItalyDepartment of Infectious Diseases (DMI), Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, ItalyEpidemiology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Via Giovanni Amendola 2, 42122 Reggio Emilia, ItalyTo investigate the association of the 2019–2020 influenza vaccine with prognosis of patients positive for SARS-CoV-2A, a large multi-database cohort study was conducted in four Italian regions (i.e., Lazio, Lombardy, Veneto, and Tuscany) and the Reggio Emilia province (Emilia-Romagna). More than 21 million adults were residing in the study area (42% of the population). We included 115,945 COVID-19 cases diagnosed during the first wave of the pandemic (February–May, 2020); 34.6% of these had been vaccinated against influenza. Three outcomes were considered: hospitalization, death, and intensive care unit (ICU) admission/death. The adjusted relative risk (RR) of being hospitalized in the vaccinated group when compared with the non-vaccinated group was 0.87 (95% CI: 0.86–0.88). This reduction in risk was not confirmed for death (RR = 1.04; 95% CI: 1.01–1.06), or for the combined outcome of ICU admission or death. In conclusion, our study, conducted on the vast majority of the population during the first wave of the pandemic in Italy, showed a 13% statistically significant reduction in the risk of hospitalization in some geographical areas and in the younger population. No impact of seasonal influenza vaccination on COVID-19 prognosis in terms of death and death or ICU admission was estimated.https://www.mdpi.com/2076-393X/9/7/716influenza vaccineCOVID-19prognosishealth databaseItaly |
| spellingShingle | Marco Massari Stefania Spila-Alegiani Massimo Fabiani Valeria Belleudi Gianluca Trifirò Ursula Kirchmayer Francesca Romana Poggi Pamela Mancuso Francesca Menniti-Ippolito Rosa Gini Claudia Bartolini Olivia Leoni Michele Ercolanoni Filippo Da-Re Stefano Guzzinati Nicoletta Luxi Flavia Riccardo Paolo Giorgi-Rossi Association of Influenza Vaccination and Prognosis in Patients Testing Positive to SARS-CoV-2 Swab Test: A Large-Scale Italian Multi-Database Cohort Study Vaccines influenza vaccine COVID-19 prognosis health database Italy |
| title | Association of Influenza Vaccination and Prognosis in Patients Testing Positive to SARS-CoV-2 Swab Test: A Large-Scale Italian Multi-Database Cohort Study |
| title_full | Association of Influenza Vaccination and Prognosis in Patients Testing Positive to SARS-CoV-2 Swab Test: A Large-Scale Italian Multi-Database Cohort Study |
| title_fullStr | Association of Influenza Vaccination and Prognosis in Patients Testing Positive to SARS-CoV-2 Swab Test: A Large-Scale Italian Multi-Database Cohort Study |
| title_full_unstemmed | Association of Influenza Vaccination and Prognosis in Patients Testing Positive to SARS-CoV-2 Swab Test: A Large-Scale Italian Multi-Database Cohort Study |
| title_short | Association of Influenza Vaccination and Prognosis in Patients Testing Positive to SARS-CoV-2 Swab Test: A Large-Scale Italian Multi-Database Cohort Study |
| title_sort | association of influenza vaccination and prognosis in patients testing positive to sars cov 2 swab test a large scale italian multi database cohort study |
| topic | influenza vaccine COVID-19 prognosis health database Italy |
| url | https://www.mdpi.com/2076-393X/9/7/716 |
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