Determination and risk assessment of naturally occurring genotoxic and carcinogenic alkenylbenzenes in basil-containing sauce of pesto
A risk assessment of basil-based pesto sauces containing methyleugenol and related alkenylbenzenes was performed based on their levels detected in a series of pesto sauces available on the Dutch market. The estimated daily intake (EDI) values of alkenylbenzenes as a result of consumption of the diff...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-01-01
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| Series: | Toxicology Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750016300920 |
| _version_ | 1818031881621340160 |
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| author | Amer J. Al-Malahmeh Abdalmajeed M. Al-ajlouni Sebastiaan Wesseling Jacques Vervoort Ivonne M.C.M. Rietjens |
| author_facet | Amer J. Al-Malahmeh Abdalmajeed M. Al-ajlouni Sebastiaan Wesseling Jacques Vervoort Ivonne M.C.M. Rietjens |
| author_sort | Amer J. Al-Malahmeh |
| collection | DOAJ |
| description | A risk assessment of basil-based pesto sauces containing methyleugenol and related alkenylbenzenes was performed based on their levels detected in a series of pesto sauces available on the Dutch market. The estimated daily intake (EDI) values of alkenylbenzenes as a result of consumption of the different pesto sauces amounted to 1.2â44.3 μg/kg bw for individual alkenylbenzenes, 14.3â43.5 μg/kg bw when adding up the alkenylbenzene levels assuming equal potency, and 17.3â62.9 μg/kg bw when expressed in methyleugenol equivalents using alkenylbenzenes defined toxic equivalency factors (TEF). The margin of exposure approach (MOE), used to evaluate the potential risks, resulted in MOE values that were generally lower than 10000 indicating a priority for risk management when assuming daily consumption. The levels of methyleugenol detected in the pesto sauces would allow consumption of 1.1â29.8, 7.5â208, 15.1â416.5, and 32.4â892.5 g of pesto sauce on a daily basis, once a week, once every two weeks, and once a month, respectively, to achieve MOE values above the 10000 limit indicating low priority for risk management. It is concluded that consumption of pesto sauces would only be of concern if consumed on a daily basis over longer periods of time. Keywords: Margin of exposure (MOE), Basil-based pesto, Combined risk assessment, Toxic equivalency factors (TEFs) |
| first_indexed | 2024-12-10T05:58:31Z |
| format | Article |
| id | doaj.art-e307753030ee4350adbb164385dc78ef |
| institution | Directory Open Access Journal |
| issn | 2214-7500 |
| language | English |
| last_indexed | 2024-12-10T05:58:31Z |
| publishDate | 2017-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj.art-e307753030ee4350adbb164385dc78ef2022-12-22T01:59:52ZengElsevierToxicology Reports2214-75002017-01-01418Determination and risk assessment of naturally occurring genotoxic and carcinogenic alkenylbenzenes in basil-containing sauce of pestoAmer J. Al-Malahmeh0Abdalmajeed M. Al-ajlouni1Sebastiaan Wesseling2Jacques Vervoort3Ivonne M.C.M. Rietjens4Division of Toxicology, Wageningen University, Stippeneng 4, 6708 WE, Wageningen, The Netherlands; Aqaba International Laboratories/BENHAYYAN, ASEZA, Aqaba 77110, Jordan; Corresponding author at: Division of Toxicology, Wageningen University, Stippeneng 4, 6708 WE, Wageningen, The Netherlands.Division of Toxicology, Wageningen University, Stippeneng 4, 6708 WE, Wageningen, The Netherlands; Aqaba International Laboratories/BENHAYYAN, ASEZA, Aqaba 77110, JordanDivision of Toxicology, Wageningen University, Stippeneng 4, 6708 WE, Wageningen, The NetherlandsLaboratory of Biochemistry, Wageningen University, Stippeneng 4, 6708 WE, Wageningen, The NetherlandsDivision of Toxicology, Wageningen University, Stippeneng 4, 6708 WE, Wageningen, The NetherlandsA risk assessment of basil-based pesto sauces containing methyleugenol and related alkenylbenzenes was performed based on their levels detected in a series of pesto sauces available on the Dutch market. The estimated daily intake (EDI) values of alkenylbenzenes as a result of consumption of the different pesto sauces amounted to 1.2â44.3 μg/kg bw for individual alkenylbenzenes, 14.3â43.5 μg/kg bw when adding up the alkenylbenzene levels assuming equal potency, and 17.3â62.9 μg/kg bw when expressed in methyleugenol equivalents using alkenylbenzenes defined toxic equivalency factors (TEF). The margin of exposure approach (MOE), used to evaluate the potential risks, resulted in MOE values that were generally lower than 10000 indicating a priority for risk management when assuming daily consumption. The levels of methyleugenol detected in the pesto sauces would allow consumption of 1.1â29.8, 7.5â208, 15.1â416.5, and 32.4â892.5 g of pesto sauce on a daily basis, once a week, once every two weeks, and once a month, respectively, to achieve MOE values above the 10000 limit indicating low priority for risk management. It is concluded that consumption of pesto sauces would only be of concern if consumed on a daily basis over longer periods of time. Keywords: Margin of exposure (MOE), Basil-based pesto, Combined risk assessment, Toxic equivalency factors (TEFs)http://www.sciencedirect.com/science/article/pii/S2214750016300920 |
| spellingShingle | Amer J. Al-Malahmeh Abdalmajeed M. Al-ajlouni Sebastiaan Wesseling Jacques Vervoort Ivonne M.C.M. Rietjens Determination and risk assessment of naturally occurring genotoxic and carcinogenic alkenylbenzenes in basil-containing sauce of pesto Toxicology Reports |
| title | Determination and risk assessment of naturally occurring genotoxic and carcinogenic alkenylbenzenes in basil-containing sauce of pesto |
| title_full | Determination and risk assessment of naturally occurring genotoxic and carcinogenic alkenylbenzenes in basil-containing sauce of pesto |
| title_fullStr | Determination and risk assessment of naturally occurring genotoxic and carcinogenic alkenylbenzenes in basil-containing sauce of pesto |
| title_full_unstemmed | Determination and risk assessment of naturally occurring genotoxic and carcinogenic alkenylbenzenes in basil-containing sauce of pesto |
| title_short | Determination and risk assessment of naturally occurring genotoxic and carcinogenic alkenylbenzenes in basil-containing sauce of pesto |
| title_sort | determination and risk assessment of naturally occurring genotoxic and carcinogenic alkenylbenzenes in basil containing sauce of pesto |
| url | http://www.sciencedirect.com/science/article/pii/S2214750016300920 |
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