Microglia autophagy in ischemic stroke: A double-edged sword
Ischemic stroke (IS) is one of the major types of cerebrovascular diseases causing neurological morbidity and mortality worldwide. In the pathophysiological process of IS, microglia play a beneficial role in tissue repair. However, it could also cause cellular damage, consequently leading to cell de...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1013311/full |
| _version_ | 1797988855904731136 |
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| author | Li Peng Li Peng Li Peng Guangqiang Hu Qianfang Yao Qianfang Yao Jianming Wu Jianming Wu Ziyang He Ziyang He Betty Yuen-Kwan Law Guishan Hu Guishan Hu Xiaogang Zhou Xiaogang Zhou Junrong Du Anguo Wu Anguo Wu Lu Yu Lu Yu Lu Yu Lu Yu |
| author_facet | Li Peng Li Peng Li Peng Guangqiang Hu Qianfang Yao Qianfang Yao Jianming Wu Jianming Wu Ziyang He Ziyang He Betty Yuen-Kwan Law Guishan Hu Guishan Hu Xiaogang Zhou Xiaogang Zhou Junrong Du Anguo Wu Anguo Wu Lu Yu Lu Yu Lu Yu Lu Yu |
| author_sort | Li Peng |
| collection | DOAJ |
| description | Ischemic stroke (IS) is one of the major types of cerebrovascular diseases causing neurological morbidity and mortality worldwide. In the pathophysiological process of IS, microglia play a beneficial role in tissue repair. However, it could also cause cellular damage, consequently leading to cell death. Inflammation is characterized by the activation of microglia, and increasing evidence showed that autophagy interacts with inflammation through regulating correlative mediators and signaling pathways. In this paper, we summarized the beneficial and harmful effects of microglia in IS. In addition, we discussed the interplay between microglia autophagy and ischemic inflammation, as along with its application in the treatment of IS. We believe this could help to provide the theoretical references for further study into IS and treatments in the future. |
| first_indexed | 2024-04-11T08:09:40Z |
| format | Article |
| id | doaj.art-e30b69b89c1a438397eff1a4546e5177 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-11T08:09:40Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-e30b69b89c1a438397eff1a4546e51772022-12-22T04:35:24ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-11-011310.3389/fimmu.2022.10133111013311Microglia autophagy in ischemic stroke: A double-edged swordLi Peng0Li Peng1Li Peng2Guangqiang Hu3Qianfang Yao4Qianfang Yao5Jianming Wu6Jianming Wu7Ziyang He8Ziyang He9Betty Yuen-Kwan Law10Guishan Hu11Guishan Hu12Xiaogang Zhou13Xiaogang Zhou14Junrong Du15Anguo Wu16Anguo Wu17Lu Yu18Lu Yu19Lu Yu20Lu Yu21Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, School of Pharmacy, Southwest Medical University, Luzhou, ChinaLuzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy, Southwest Medical University, Luzhou, ChinaDepartment of Medicine Imaging, School of Clinical Medicine, Southwest Medical University, Luzhou, ChinaDepartment of Anatomy, School of Basic Medical Sciences, Southwest Medical University, Luzhou, ChinaSichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, School of Pharmacy, Southwest Medical University, Luzhou, ChinaLuzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy, Southwest Medical University, Luzhou, ChinaSichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, School of Pharmacy, Southwest Medical University, Luzhou, ChinaLuzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy, Southwest Medical University, Luzhou, ChinaSichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, School of Pharmacy, Southwest Medical University, Luzhou, ChinaLuzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy, Southwest Medical University, Luzhou, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macao, Macao SAR, ChinaSichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, School of Pharmacy, Southwest Medical University, Luzhou, ChinaLuzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy, Southwest Medical University, Luzhou, ChinaSichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, School of Pharmacy, Southwest Medical University, Luzhou, ChinaLuzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy, Southwest Medical University, Luzhou, ChinaKey Laboratory of Drug Targeting and Drug Delivery Systems of Ministry of Education, Department of Pharmacology, West China School of Pharmacy, Sichuan University, Chengdu, ChinaSichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, School of Pharmacy, Southwest Medical University, Luzhou, ChinaLuzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy, Southwest Medical University, Luzhou, ChinaSichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, School of Pharmacy, Southwest Medical University, Luzhou, ChinaLuzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy, Southwest Medical University, Luzhou, ChinaDepartment of Medicine Imaging, School of Clinical Medicine, Southwest Medical University, Luzhou, ChinaDepartment of Chemistry, School of Basic Medical Sciences, Southwest Medical University, Luzhou, ChinaIschemic stroke (IS) is one of the major types of cerebrovascular diseases causing neurological morbidity and mortality worldwide. In the pathophysiological process of IS, microglia play a beneficial role in tissue repair. However, it could also cause cellular damage, consequently leading to cell death. Inflammation is characterized by the activation of microglia, and increasing evidence showed that autophagy interacts with inflammation through regulating correlative mediators and signaling pathways. In this paper, we summarized the beneficial and harmful effects of microglia in IS. In addition, we discussed the interplay between microglia autophagy and ischemic inflammation, as along with its application in the treatment of IS. We believe this could help to provide the theoretical references for further study into IS and treatments in the future.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1013311/fullischemic strokemicrogliaautophagyneuroinflammationtherapy |
| spellingShingle | Li Peng Li Peng Li Peng Guangqiang Hu Qianfang Yao Qianfang Yao Jianming Wu Jianming Wu Ziyang He Ziyang He Betty Yuen-Kwan Law Guishan Hu Guishan Hu Xiaogang Zhou Xiaogang Zhou Junrong Du Anguo Wu Anguo Wu Lu Yu Lu Yu Lu Yu Lu Yu Microglia autophagy in ischemic stroke: A double-edged sword Frontiers in Immunology ischemic stroke microglia autophagy neuroinflammation therapy |
| title | Microglia autophagy in ischemic stroke: A double-edged sword |
| title_full | Microglia autophagy in ischemic stroke: A double-edged sword |
| title_fullStr | Microglia autophagy in ischemic stroke: A double-edged sword |
| title_full_unstemmed | Microglia autophagy in ischemic stroke: A double-edged sword |
| title_short | Microglia autophagy in ischemic stroke: A double-edged sword |
| title_sort | microglia autophagy in ischemic stroke a double edged sword |
| topic | ischemic stroke microglia autophagy neuroinflammation therapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1013311/full |
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