Pathophysiological and clinical point of view on Kawasaki disease and MIS-C
This article compares two important pathophysiological states, Kawasaki disease, and multisystem inflammatory syndrome, in children associated with COVID-19 (MIS-C). Both occur predominantly in children, have a temporal association with an infectious agent, and are associated with immune-system alte...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Pediatrics and Neonatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957223001079 |
| _version_ | 1797672111907536896 |
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| author | Lenka Vaňková Jiří Bufka Věra Křížková |
| author_facet | Lenka Vaňková Jiří Bufka Věra Křížková |
| author_sort | Lenka Vaňková |
| collection | DOAJ |
| description | This article compares two important pathophysiological states, Kawasaki disease, and multisystem inflammatory syndrome, in children associated with COVID-19 (MIS-C). Both occur predominantly in children, have a temporal association with an infectious agent, and are associated with immune-system alteration and systemic inflammation under certain circumstances. The two share common pathophysiology, including enhancement of interleukin-1 neutrophils, activation of the inflammasome, pyroptosis, or NETosis. Moreover, the clinical presentation of the diseases overlaps. However, they are indeed two separate diseases, proven by the differences in the epidemiological and etiological aspects and the pathophysiological processes involved in the development and frequency of some clinical signs. This article highlights potentially exciting areas that have not yet been studied in detail, which could help better understand the development of these diseases. |
| first_indexed | 2024-03-11T21:25:20Z |
| format | Article |
| id | doaj.art-e30bec1118734cd2b0813c0dab0112f1 |
| institution | Directory Open Access Journal |
| issn | 1875-9572 |
| language | English |
| last_indexed | 2024-03-11T21:25:20Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj.art-e30bec1118734cd2b0813c0dab0112f12023-09-28T05:25:15ZengElsevierPediatrics and Neonatology1875-95722023-09-01645495504Pathophysiological and clinical point of view on Kawasaki disease and MIS-CLenka Vaňková0Jiří Bufka1Věra Křížková2Department of Histology and Embryology, Faculty of Medicine in Pilsen, Charles University, Czech Republic; Corresponding author. Department of Histology and Embryology, Faculty of Medicine in Pilsen, Charles University in Prague, alej Svobody 76, Pilsen, 323 00, Czech Republic.Department of Pediatrics, Teaching Hospital in Pilsen, Czech RepublicDepartment of Histology and Embryology, Faculty of Medicine in Pilsen, Charles University, Czech RepublicThis article compares two important pathophysiological states, Kawasaki disease, and multisystem inflammatory syndrome, in children associated with COVID-19 (MIS-C). Both occur predominantly in children, have a temporal association with an infectious agent, and are associated with immune-system alteration and systemic inflammation under certain circumstances. The two share common pathophysiology, including enhancement of interleukin-1 neutrophils, activation of the inflammasome, pyroptosis, or NETosis. Moreover, the clinical presentation of the diseases overlaps. However, they are indeed two separate diseases, proven by the differences in the epidemiological and etiological aspects and the pathophysiological processes involved in the development and frequency of some clinical signs. This article highlights potentially exciting areas that have not yet been studied in detail, which could help better understand the development of these diseases.http://www.sciencedirect.com/science/article/pii/S1875957223001079COVID-19Kawasaki diseaseMIS-C |
| spellingShingle | Lenka Vaňková Jiří Bufka Věra Křížková Pathophysiological and clinical point of view on Kawasaki disease and MIS-C Pediatrics and Neonatology COVID-19 Kawasaki disease MIS-C |
| title | Pathophysiological and clinical point of view on Kawasaki disease and MIS-C |
| title_full | Pathophysiological and clinical point of view on Kawasaki disease and MIS-C |
| title_fullStr | Pathophysiological and clinical point of view on Kawasaki disease and MIS-C |
| title_full_unstemmed | Pathophysiological and clinical point of view on Kawasaki disease and MIS-C |
| title_short | Pathophysiological and clinical point of view on Kawasaki disease and MIS-C |
| title_sort | pathophysiological and clinical point of view on kawasaki disease and mis c |
| topic | COVID-19 Kawasaki disease MIS-C |
| url | http://www.sciencedirect.com/science/article/pii/S1875957223001079 |
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