Discovering Conserved Properties of Brain Organization Through Multimodal Integration and Interspecies Comparison
The primate cerebral cortex is broadly organized along hierarchical processing streams underpinned by corresponding variation in the brain’s microstructure and interareal connectivity patterns. Fulcher et al. recently demonstrated that a similar organization exists in the mouse cortex by combining i...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2019-07-01
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| Series: | Journal of Experimental Neuroscience |
| Online Access: | https://doi.org/10.1177/1179069519862047 |
| _version_ | 1798022747965620224 |
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| author | Ben D Fulcher |
| author_facet | Ben D Fulcher |
| author_sort | Ben D Fulcher |
| collection | DOAJ |
| description | The primate cerebral cortex is broadly organized along hierarchical processing streams underpinned by corresponding variation in the brain’s microstructure and interareal connectivity patterns. Fulcher et al. recently demonstrated that a similar organization exists in the mouse cortex by combining independent datasets of cytoarchitecture, gene expression, cell densities, and long-range axonal connectivity. Using the T1w:T2w magnetic resonance imaging map as a common spatial reference for data-driven comparison of cortical gradients between mouse and human, we highlighted a common hierarchical expression pattern of numerous brain-related genes, providing new understanding of how systematic structural variation shapes functional specialization in mammalian brains. Reflecting on these findings, here we discuss how open neuroscience datasets, combined with advanced neuroinformatics approaches, will be crucial in the ongoing search for organization principles of brain structure. We explore the promises and challenges of integrative studies and argue that a tighter collaboration between experimental, statistical, and theoretical neuroscientists is needed to drive progress further. |
| first_indexed | 2024-04-11T17:35:03Z |
| format | Article |
| id | doaj.art-e30c0e4322cb4ad49ca042a7d420d781 |
| institution | Directory Open Access Journal |
| issn | 1179-0695 |
| language | English |
| last_indexed | 2024-04-11T17:35:03Z |
| publishDate | 2019-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Experimental Neuroscience |
| spelling | doaj.art-e30c0e4322cb4ad49ca042a7d420d7812022-12-22T04:11:43ZengSAGE PublishingJournal of Experimental Neuroscience1179-06952019-07-011310.1177/1179069519862047Discovering Conserved Properties of Brain Organization Through Multimodal Integration and Interspecies ComparisonBen D FulcherThe primate cerebral cortex is broadly organized along hierarchical processing streams underpinned by corresponding variation in the brain’s microstructure and interareal connectivity patterns. Fulcher et al. recently demonstrated that a similar organization exists in the mouse cortex by combining independent datasets of cytoarchitecture, gene expression, cell densities, and long-range axonal connectivity. Using the T1w:T2w magnetic resonance imaging map as a common spatial reference for data-driven comparison of cortical gradients between mouse and human, we highlighted a common hierarchical expression pattern of numerous brain-related genes, providing new understanding of how systematic structural variation shapes functional specialization in mammalian brains. Reflecting on these findings, here we discuss how open neuroscience datasets, combined with advanced neuroinformatics approaches, will be crucial in the ongoing search for organization principles of brain structure. We explore the promises and challenges of integrative studies and argue that a tighter collaboration between experimental, statistical, and theoretical neuroscientists is needed to drive progress further.https://doi.org/10.1177/1179069519862047 |
| spellingShingle | Ben D Fulcher Discovering Conserved Properties of Brain Organization Through Multimodal Integration and Interspecies Comparison Journal of Experimental Neuroscience |
| title | Discovering Conserved Properties of Brain Organization Through Multimodal Integration and Interspecies Comparison |
| title_full | Discovering Conserved Properties of Brain Organization Through Multimodal Integration and Interspecies Comparison |
| title_fullStr | Discovering Conserved Properties of Brain Organization Through Multimodal Integration and Interspecies Comparison |
| title_full_unstemmed | Discovering Conserved Properties of Brain Organization Through Multimodal Integration and Interspecies Comparison |
| title_short | Discovering Conserved Properties of Brain Organization Through Multimodal Integration and Interspecies Comparison |
| title_sort | discovering conserved properties of brain organization through multimodal integration and interspecies comparison |
| url | https://doi.org/10.1177/1179069519862047 |
| work_keys_str_mv | AT bendfulcher discoveringconservedpropertiesofbrainorganizationthroughmultimodalintegrationandinterspeciescomparison |