The protective and pathogenic role of Th17 cell plasticity and function in the tumor microenvironment
At the turn of the century, researchers discovered a unique subtype of T helper cells that secretes IL-17 and defined it as Th17. The latest study found that Th17 cells play both positive and negative definitive roles in the regulation of antitumor immune responses. Although the function of Th17 in...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1192303/full |
| _version_ | 1827913556024098816 |
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| author | Yuanyuan Pan Wenjing Yang Bo Tang Xiaobo Wang Qi Zhang Weiping Li Li Li |
| author_facet | Yuanyuan Pan Wenjing Yang Bo Tang Xiaobo Wang Qi Zhang Weiping Li Li Li |
| author_sort | Yuanyuan Pan |
| collection | DOAJ |
| description | At the turn of the century, researchers discovered a unique subtype of T helper cells that secretes IL-17 and defined it as Th17. The latest study found that Th17 cells play both positive and negative definitive roles in the regulation of antitumor immune responses. Although the function of Th17 in the tumor microenvironment remains poorly understood, more and more studies have shown that this paradoxical dual role is closely related to the plasticity of Th17 cells in recent decades. Further understanding of the characteristics of Th17 cells in the tumor microenvironment could yield novel and useful therapeutic approaches to treat cancer. In this review, we further present the high plasticity of Th17 cells and the function of Th17-producing IL-17 in tumor immunity. |
| first_indexed | 2024-03-13T02:31:35Z |
| format | Article |
| id | doaj.art-e30c2057ee2146aeb52a753df31b5776 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-13T02:31:35Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-e30c2057ee2146aeb52a753df31b57762023-06-29T15:30:43ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-06-011410.3389/fimmu.2023.11923031192303The protective and pathogenic role of Th17 cell plasticity and function in the tumor microenvironmentYuanyuan PanWenjing YangBo TangXiaobo WangQi ZhangWeiping LiLi LiAt the turn of the century, researchers discovered a unique subtype of T helper cells that secretes IL-17 and defined it as Th17. The latest study found that Th17 cells play both positive and negative definitive roles in the regulation of antitumor immune responses. Although the function of Th17 in the tumor microenvironment remains poorly understood, more and more studies have shown that this paradoxical dual role is closely related to the plasticity of Th17 cells in recent decades. Further understanding of the characteristics of Th17 cells in the tumor microenvironment could yield novel and useful therapeutic approaches to treat cancer. In this review, we further present the high plasticity of Th17 cells and the function of Th17-producing IL-17 in tumor immunity.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1192303/fulltumor microenvironmentcancerTh17TregTh1IL-17 |
| spellingShingle | Yuanyuan Pan Wenjing Yang Bo Tang Xiaobo Wang Qi Zhang Weiping Li Li Li The protective and pathogenic role of Th17 cell plasticity and function in the tumor microenvironment Frontiers in Immunology tumor microenvironment cancer Th17 Treg Th1 IL-17 |
| title | The protective and pathogenic role of Th17 cell plasticity and function in the tumor microenvironment |
| title_full | The protective and pathogenic role of Th17 cell plasticity and function in the tumor microenvironment |
| title_fullStr | The protective and pathogenic role of Th17 cell plasticity and function in the tumor microenvironment |
| title_full_unstemmed | The protective and pathogenic role of Th17 cell plasticity and function in the tumor microenvironment |
| title_short | The protective and pathogenic role of Th17 cell plasticity and function in the tumor microenvironment |
| title_sort | protective and pathogenic role of th17 cell plasticity and function in the tumor microenvironment |
| topic | tumor microenvironment cancer Th17 Treg Th1 IL-17 |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1192303/full |
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