Salivary microbiota in individuals with different levels of caries experience
This study compared salivary bacterial profiles in two groups having a 10-fold difference in levels of caries experience, as it was hypothesized that the composition of the salivary microbiota might associate with the levels of caries experience. Bacterial profiles in stimulated saliva samples from...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-01-01
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| Series: | Journal of Oral Microbiology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/20002297.2016.1270614 |
| _version_ | 1818447847168671744 |
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| author | Daniel Belstrøm Palle Holmstrup Nils-Erik Fiehn Nikolai Kirkby Alexis Kokaras Bruce J. Paster Allan Bardow |
| author_facet | Daniel Belstrøm Palle Holmstrup Nils-Erik Fiehn Nikolai Kirkby Alexis Kokaras Bruce J. Paster Allan Bardow |
| author_sort | Daniel Belstrøm |
| collection | DOAJ |
| description | This study compared salivary bacterial profiles in two groups having a 10-fold difference in levels of caries experience, as it was hypothesized that the composition of the salivary microbiota might associate with the levels of caries experience. Bacterial profiles in stimulated saliva samples from 85 individuals with low levels of caries experience (healthy group) and 79 individuals with high levels of caries experience (caries group) were analyzed by means of the Human Oral Microbiome Identification Next Generation Sequencing (HOMINGS) technique. Subsequently, saliva samples from caries-free individuals in the healthy group (n = 57) and the caries group (n = 31) were compared. A significantly higher α-diversity (p < 0.0001) and a twofold higher relative abundance of Neisseria, Haemophilus, and Fusobacterium were recorded in saliva samples from the healthy group compared with the caries group. Differences observed were more pronounced when limiting the analyses to caries-free individuals in each group. Data from this cross-sectional analysis suggest that low levels of caries experience might associate with a characteristic salivary bacterial composition different from that in individuals with high caries experience. Consequently, longitudinal studies are required to determine if the composition of the salivary microbiota might be a predictive factor of caries risk at the individual level. |
| first_indexed | 2024-12-14T20:10:07Z |
| format | Article |
| id | doaj.art-e30c785ba6d34b17af90a9b240e9bac4 |
| institution | Directory Open Access Journal |
| issn | 2000-2297 |
| language | English |
| last_indexed | 2024-12-14T20:10:07Z |
| publishDate | 2017-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Oral Microbiology |
| spelling | doaj.art-e30c785ba6d34b17af90a9b240e9bac42022-12-21T22:48:57ZengTaylor & Francis GroupJournal of Oral Microbiology2000-22972017-01-019110.1080/20002297.2016.12706141270614Salivary microbiota in individuals with different levels of caries experienceDaniel Belstrøm0Palle Holmstrup1Nils-Erik Fiehn2Nikolai Kirkby3Alexis Kokaras4Bruce J. Paster5Allan Bardow6Section for Periodontology, Microbiology, and Community DentistrySection for Periodontology, Microbiology, and Community DentistryUniversity of CopenhagenCopenhagen University HospitalThe Forsyth InstituteThe Forsyth InstituteUniversity of CopenhagenThis study compared salivary bacterial profiles in two groups having a 10-fold difference in levels of caries experience, as it was hypothesized that the composition of the salivary microbiota might associate with the levels of caries experience. Bacterial profiles in stimulated saliva samples from 85 individuals with low levels of caries experience (healthy group) and 79 individuals with high levels of caries experience (caries group) were analyzed by means of the Human Oral Microbiome Identification Next Generation Sequencing (HOMINGS) technique. Subsequently, saliva samples from caries-free individuals in the healthy group (n = 57) and the caries group (n = 31) were compared. A significantly higher α-diversity (p < 0.0001) and a twofold higher relative abundance of Neisseria, Haemophilus, and Fusobacterium were recorded in saliva samples from the healthy group compared with the caries group. Differences observed were more pronounced when limiting the analyses to caries-free individuals in each group. Data from this cross-sectional analysis suggest that low levels of caries experience might associate with a characteristic salivary bacterial composition different from that in individuals with high caries experience. Consequently, longitudinal studies are required to determine if the composition of the salivary microbiota might be a predictive factor of caries risk at the individual level.http://dx.doi.org/10.1080/20002297.2016.1270614Caries susceptibilitymicrobiologyHOMINGSoral diagnosisclinical studies/trials |
| spellingShingle | Daniel Belstrøm Palle Holmstrup Nils-Erik Fiehn Nikolai Kirkby Alexis Kokaras Bruce J. Paster Allan Bardow Salivary microbiota in individuals with different levels of caries experience Journal of Oral Microbiology Caries susceptibility microbiology HOMINGS oral diagnosis clinical studies/trials |
| title | Salivary microbiota in individuals with different levels of caries experience |
| title_full | Salivary microbiota in individuals with different levels of caries experience |
| title_fullStr | Salivary microbiota in individuals with different levels of caries experience |
| title_full_unstemmed | Salivary microbiota in individuals with different levels of caries experience |
| title_short | Salivary microbiota in individuals with different levels of caries experience |
| title_sort | salivary microbiota in individuals with different levels of caries experience |
| topic | Caries susceptibility microbiology HOMINGS oral diagnosis clinical studies/trials |
| url | http://dx.doi.org/10.1080/20002297.2016.1270614 |
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