Innate immune evasion by alphaviruses
Alphaviruses contain many human and animal pathogens, such as CHIKV, SINV, and VEEV. Accumulating evidence indicates that innate immunity plays an important role in response to alphaviruses infection. In parallel, alphaviruses have evolved many strategies to evade host antiviral innate immunity. In...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1005586/full |
| _version_ | 1811209712615555072 |
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| author | Yihan Liu Yihan Liu Yihan Liu Yupei Yuan Yupei Yuan Leiliang Zhang Leiliang Zhang Leiliang Zhang |
| author_facet | Yihan Liu Yihan Liu Yihan Liu Yupei Yuan Yupei Yuan Leiliang Zhang Leiliang Zhang Leiliang Zhang |
| author_sort | Yihan Liu |
| collection | DOAJ |
| description | Alphaviruses contain many human and animal pathogens, such as CHIKV, SINV, and VEEV. Accumulating evidence indicates that innate immunity plays an important role in response to alphaviruses infection. In parallel, alphaviruses have evolved many strategies to evade host antiviral innate immunity. In the current review, we focus on the underlying mechanisms employed by alphaviruses to evade cGAS-STING, IFN, transcriptional host shutoff, translational host shutoff, and RNAi. Dissecting the detailed antiviral immune evasion mechanisms by alphaviruses will enhance our understanding of the pathogenesis of alphaviruses and may provide more effective strategies to control alphaviruses infection. |
| first_indexed | 2024-04-12T04:44:08Z |
| format | Article |
| id | doaj.art-e30cabb67ebe4f22ac576189c18a9590 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T04:44:08Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-e30cabb67ebe4f22ac576189c18a95902022-12-22T03:47:33ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-09-011310.3389/fimmu.2022.10055861005586Innate immune evasion by alphavirusesYihan Liu0Yihan Liu1Yihan Liu2Yupei Yuan3Yupei Yuan4Leiliang Zhang5Leiliang Zhang6Leiliang Zhang7Department of Infectious Diseases, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Pathogen Biology, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaMedical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaDepartment of Pathogen Biology, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaMedical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaDepartment of Infectious Diseases, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Pathogen Biology, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaMedical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaAlphaviruses contain many human and animal pathogens, such as CHIKV, SINV, and VEEV. Accumulating evidence indicates that innate immunity plays an important role in response to alphaviruses infection. In parallel, alphaviruses have evolved many strategies to evade host antiviral innate immunity. In the current review, we focus on the underlying mechanisms employed by alphaviruses to evade cGAS-STING, IFN, transcriptional host shutoff, translational host shutoff, and RNAi. Dissecting the detailed antiviral immune evasion mechanisms by alphaviruses will enhance our understanding of the pathogenesis of alphaviruses and may provide more effective strategies to control alphaviruses infection.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1005586/fullinnate immune evasionalphavirusCHIKVinterferonSTING |
| spellingShingle | Yihan Liu Yihan Liu Yihan Liu Yupei Yuan Yupei Yuan Leiliang Zhang Leiliang Zhang Leiliang Zhang Innate immune evasion by alphaviruses Frontiers in Immunology innate immune evasion alphavirus CHIKV interferon STING |
| title | Innate immune evasion by alphaviruses |
| title_full | Innate immune evasion by alphaviruses |
| title_fullStr | Innate immune evasion by alphaviruses |
| title_full_unstemmed | Innate immune evasion by alphaviruses |
| title_short | Innate immune evasion by alphaviruses |
| title_sort | innate immune evasion by alphaviruses |
| topic | innate immune evasion alphavirus CHIKV interferon STING |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1005586/full |
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