Risk Factors and Disease Profile Associated with the Nucleic Acid Conversion Time of COVID-19 Patients Infected with the SARS-CoV-2 Omicron Variant in Fangcang Shelter Hospitals
Shaolei Ma,* Haofei Wang,* Kongbo Zhu, Hui Chen, Jianfeng Xie, Yingzi Huang Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, Nanjing, 210009, People’s Republic of China*These authors contributed equally to th...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-06-01
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| Series: | Infection and Drug Resistance |
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| Online Access: | https://www.dovepress.com/risk-factors-and-disease-profile-associated-with-the-nucleic-acid-conv-peer-reviewed-fulltext-article-IDR |
| _version_ | 1797789463430037504 |
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| author | Ma S Wang H Zhu K Chen H Xie J Huang Y |
| author_facet | Ma S Wang H Zhu K Chen H Xie J Huang Y |
| author_sort | Ma S |
| collection | DOAJ |
| description | Shaolei Ma,* Haofei Wang,* Kongbo Zhu, Hui Chen, Jianfeng Xie, Yingzi Huang Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, Nanjing, 210009, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yingzi Huang, Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, People’s Republic of China, Tel +86-025-83262553, Email yz_huang@126.comPurpose: This study aimed to determine the clinical profile connected to the nucleic acid conversion time of COVID-19 patients harboring the SARS-CoV-2 Omicron variant at the hospitals at the Fangcang shelter.Methods: We reported 39,584 COVID-19 patients who were hospitalized in Shanghai, China, between April 5 and May 5, 2022, and who had contracted the Omicron strain of SARS-CoV-2. Demographic data, medical and vaccination history, clinical symptoms, and NCT were reported for the patient.Results: The median age of the patients with COVID-19 included in this study was 45 (interquartile range [IQR]: 33– 54), and 64.2% of them were male. The two most prevalent comorbidities among the patients were hypertension and diabetes. Additionally, we discovered that the percentage of unimmunized patients was negligible (13.2%). We found that male sex, age under 60, and other comorbidities including hypertension and diabetes are significant risk factors for extending NCT when we analyzed the risk variables for NCT. We discovered that vaccination with two or more doses can significantly reduce NCT. The analysis of the young (18– 59 years) and older (60 years) populations produced the same outcomes.Conclusion: Our findings confirm that a full COVID-19 vaccine series or booster doses are highly recommended to significantly reduce NCT. In order to reduce NCT, it is also advised that elderly people who have no clear contraindications take vaccination shots.Keywords: COVID-19, nucleic acid conversion time, Fangcang shelter hospitals, vaccination |
| first_indexed | 2024-03-13T01:50:59Z |
| format | Article |
| id | doaj.art-e30e4b620f0b4ced83ec5d1d9f32bf99 |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-03-13T01:50:59Z |
| publishDate | 2023-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-e30e4b620f0b4ced83ec5d1d9f32bf992023-07-02T19:49:16ZengDove Medical PressInfection and Drug Resistance1178-69732023-06-01Volume 163945395484579Risk Factors and Disease Profile Associated with the Nucleic Acid Conversion Time of COVID-19 Patients Infected with the SARS-CoV-2 Omicron Variant in Fangcang Shelter HospitalsMa SWang HZhu KChen HXie JHuang YShaolei Ma,* Haofei Wang,* Kongbo Zhu, Hui Chen, Jianfeng Xie, Yingzi Huang Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, Nanjing, 210009, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yingzi Huang, Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, People’s Republic of China, Tel +86-025-83262553, Email yz_huang@126.comPurpose: This study aimed to determine the clinical profile connected to the nucleic acid conversion time of COVID-19 patients harboring the SARS-CoV-2 Omicron variant at the hospitals at the Fangcang shelter.Methods: We reported 39,584 COVID-19 patients who were hospitalized in Shanghai, China, between April 5 and May 5, 2022, and who had contracted the Omicron strain of SARS-CoV-2. Demographic data, medical and vaccination history, clinical symptoms, and NCT were reported for the patient.Results: The median age of the patients with COVID-19 included in this study was 45 (interquartile range [IQR]: 33– 54), and 64.2% of them were male. The two most prevalent comorbidities among the patients were hypertension and diabetes. Additionally, we discovered that the percentage of unimmunized patients was negligible (13.2%). We found that male sex, age under 60, and other comorbidities including hypertension and diabetes are significant risk factors for extending NCT when we analyzed the risk variables for NCT. We discovered that vaccination with two or more doses can significantly reduce NCT. The analysis of the young (18– 59 years) and older (60 years) populations produced the same outcomes.Conclusion: Our findings confirm that a full COVID-19 vaccine series or booster doses are highly recommended to significantly reduce NCT. In order to reduce NCT, it is also advised that elderly people who have no clear contraindications take vaccination shots.Keywords: COVID-19, nucleic acid conversion time, Fangcang shelter hospitals, vaccinationhttps://www.dovepress.com/risk-factors-and-disease-profile-associated-with-the-nucleic-acid-conv-peer-reviewed-fulltext-article-IDRcovid-19nucleic acid conversion timefangcang shelter hospitalsvaccination |
| spellingShingle | Ma S Wang H Zhu K Chen H Xie J Huang Y Risk Factors and Disease Profile Associated with the Nucleic Acid Conversion Time of COVID-19 Patients Infected with the SARS-CoV-2 Omicron Variant in Fangcang Shelter Hospitals Infection and Drug Resistance covid-19 nucleic acid conversion time fangcang shelter hospitals vaccination |
| title | Risk Factors and Disease Profile Associated with the Nucleic Acid Conversion Time of COVID-19 Patients Infected with the SARS-CoV-2 Omicron Variant in Fangcang Shelter Hospitals |
| title_full | Risk Factors and Disease Profile Associated with the Nucleic Acid Conversion Time of COVID-19 Patients Infected with the SARS-CoV-2 Omicron Variant in Fangcang Shelter Hospitals |
| title_fullStr | Risk Factors and Disease Profile Associated with the Nucleic Acid Conversion Time of COVID-19 Patients Infected with the SARS-CoV-2 Omicron Variant in Fangcang Shelter Hospitals |
| title_full_unstemmed | Risk Factors and Disease Profile Associated with the Nucleic Acid Conversion Time of COVID-19 Patients Infected with the SARS-CoV-2 Omicron Variant in Fangcang Shelter Hospitals |
| title_short | Risk Factors and Disease Profile Associated with the Nucleic Acid Conversion Time of COVID-19 Patients Infected with the SARS-CoV-2 Omicron Variant in Fangcang Shelter Hospitals |
| title_sort | risk factors and disease profile associated with the nucleic acid conversion time of covid 19 patients infected with the sars cov 2 omicron variant in fangcang shelter hospitals |
| topic | covid-19 nucleic acid conversion time fangcang shelter hospitals vaccination |
| url | https://www.dovepress.com/risk-factors-and-disease-profile-associated-with-the-nucleic-acid-conv-peer-reviewed-fulltext-article-IDR |
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