The Role of High-Density Lipoproteins in Endothelial Cell Metabolism and Diabetes-Impaired Angiogenesis
Diabetes mellitus affects millions of people worldwide and is associated with devastating vascular complications. A number of these complications, such as impaired wound healing and poor coronary collateral circulation, are characterised by impaired ischaemia-driven angiogenesis. There is increasing...
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MDPI AG
2020-05-01
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Series: | International Journal of Molecular Sciences |
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Online Access: | https://www.mdpi.com/1422-0067/21/10/3633 |
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author | Khalia R. Primer Peter J. Psaltis Joanne T.M. Tan Christina A. Bursill |
author_facet | Khalia R. Primer Peter J. Psaltis Joanne T.M. Tan Christina A. Bursill |
author_sort | Khalia R. Primer |
collection | DOAJ |
description | Diabetes mellitus affects millions of people worldwide and is associated with devastating vascular complications. A number of these complications, such as impaired wound healing and poor coronary collateral circulation, are characterised by impaired ischaemia-driven angiogenesis. There is increasing evidence that high-density lipoproteins (HDL) can rescue diabetes-impaired angiogenesis through a number of mechanisms, including the modulation of endothelial cell metabolic reprogramming. Endothelial cell metabolic reprogramming in response to tissue ischaemia is a driver of angiogenesis and is dysregulated by diabetes. Specifically, diabetes impairs pathways that allow endothelial cells to upregulate glycolysis in response to hypoxia adequately and impairs suppression of mitochondrial respiration. HDL rescues the impairment of the central hypoxia signalling pathway, which regulates these metabolic changes, and this may underpin several of its known pro-angiogenic effects. This review discusses the current understanding of endothelial cell metabolism and how diabetes leads to its dysregulation whilst examining the various positive effects of HDL on endothelial cell function. |
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issn | 1661-6596 1422-0067 |
language | English |
last_indexed | 2024-03-10T19:42:17Z |
publishDate | 2020-05-01 |
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series | International Journal of Molecular Sciences |
spelling | doaj.art-e30e68e8b5484e3eb6b789b7e2947d132023-11-20T01:13:27ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-05-012110363310.3390/ijms21103633The Role of High-Density Lipoproteins in Endothelial Cell Metabolism and Diabetes-Impaired AngiogenesisKhalia R. Primer0Peter J. Psaltis1Joanne T.M. Tan2Christina A. Bursill3Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Australia 5000, AustraliaFaculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Australia 5000, AustraliaFaculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Australia 5000, AustraliaFaculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Australia 5000, AustraliaDiabetes mellitus affects millions of people worldwide and is associated with devastating vascular complications. A number of these complications, such as impaired wound healing and poor coronary collateral circulation, are characterised by impaired ischaemia-driven angiogenesis. There is increasing evidence that high-density lipoproteins (HDL) can rescue diabetes-impaired angiogenesis through a number of mechanisms, including the modulation of endothelial cell metabolic reprogramming. Endothelial cell metabolic reprogramming in response to tissue ischaemia is a driver of angiogenesis and is dysregulated by diabetes. Specifically, diabetes impairs pathways that allow endothelial cells to upregulate glycolysis in response to hypoxia adequately and impairs suppression of mitochondrial respiration. HDL rescues the impairment of the central hypoxia signalling pathway, which regulates these metabolic changes, and this may underpin several of its known pro-angiogenic effects. This review discusses the current understanding of endothelial cell metabolism and how diabetes leads to its dysregulation whilst examining the various positive effects of HDL on endothelial cell function.https://www.mdpi.com/1422-0067/21/10/3633diabetes mellitusangiogenesishigh-density lipoproteinendothelial cellmetabolismmetabolic reprogramming |
spellingShingle | Khalia R. Primer Peter J. Psaltis Joanne T.M. Tan Christina A. Bursill The Role of High-Density Lipoproteins in Endothelial Cell Metabolism and Diabetes-Impaired Angiogenesis International Journal of Molecular Sciences diabetes mellitus angiogenesis high-density lipoprotein endothelial cell metabolism metabolic reprogramming |
title | The Role of High-Density Lipoproteins in Endothelial Cell Metabolism and Diabetes-Impaired Angiogenesis |
title_full | The Role of High-Density Lipoproteins in Endothelial Cell Metabolism and Diabetes-Impaired Angiogenesis |
title_fullStr | The Role of High-Density Lipoproteins in Endothelial Cell Metabolism and Diabetes-Impaired Angiogenesis |
title_full_unstemmed | The Role of High-Density Lipoproteins in Endothelial Cell Metabolism and Diabetes-Impaired Angiogenesis |
title_short | The Role of High-Density Lipoproteins in Endothelial Cell Metabolism and Diabetes-Impaired Angiogenesis |
title_sort | role of high density lipoproteins in endothelial cell metabolism and diabetes impaired angiogenesis |
topic | diabetes mellitus angiogenesis high-density lipoprotein endothelial cell metabolism metabolic reprogramming |
url | https://www.mdpi.com/1422-0067/21/10/3633 |
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